Laser-induced explosive desorption

Fain, Benjamin; Lin, Sheng Hsien

doi:10.1063/1.456982

Cited by 18 publications

(16 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8,11,16,17 At this power density, the irradiated foil undergoes such an extreme temperature change that a metal plasma is formed. 18 A more detailed description of how this ablation occurs will be given below but, for now, the generation of acoustic waves is the focus. The key to the generation of acoustic waves in this regime is conservation of momentum.…”

Section: Generation Of Acoustic Waves For Laser-induced Acoustic Desomentioning

confidence: 99%

“…A detailed description of the processes following irradiation of a metal foil by an ultraviolet laser pulse has been published by Fain and Lin for the ablative regime. 18 Upon laser irradiation, the metal atoms in the foil become electronically excited. These excited atoms can undergo intersystem crossing to vibronic states, which interact strongly with the phonons (a representation of a vibrational state 20 ) of the metal.…”

Section: Laser Pulse Irradiation and Ablationmentioning

confidence: 99%

“…These processes are represented in Figure 3. 18 The result of this interaction is that as more energy is deposited into the metal from the laser, the phonons of the metal become more excited. While these phonons decay over time, the amplification rate is much greater than the decay rate.…”

Section: Laser Pulse Irradiation and Ablationmentioning

confidence: 99%

See 2 more Smart Citations

Laser-Induced Acoustic Desorption Mass Spectrometry

Dow

Wittrig

Kenttämaa

2012

Eur J Mass Spectrom (Chichester)

View full text Add to dashboard Cite

Large thermally labile molecules were not amenable to mass spectrometric analysis until the development of atmospheric pressure evaporation/ionization methods, such as electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI), since attempts to evaporate these molecules by heating induces degradation of the sample. While ESI and MALDI are relatively soft desorption/ionization techniques, they are both limited to preferential ionization of acidic and basic analytes. This limitation has been the driving force for the development of other soft desorption/ionization techniques. One such method employs laser-induced acoustic desorption (LIAD) to evaporate neutral sample molecules into mass spectrometers. LIAD utilizes acoustic waves generated by a laser pulse in a thin metal foil. The acoustic waves travel through the foil and cause desorption of neutral molecules that have been deposited on the opposite side of the foil. One of the advantages of LIAD is that it desorbs low-energy molecules that can be ionized by a variety of methods, thus allowing the analysis of large molecules that are not amenable to ESI and MALDI. This review covers the generation of acoustic waves in foils via a laser pulse, the parameters affecting the generation of acoustic waves, possible mechanisms for desorption of neutral molecules, as well as the various uses of LIAD by mass spectrometrists. The conditions used to generate acoustic or stress waves in solid materials consist of three regimes: thermal, ablative, and constrained. Each regime is discussed, in addition to the mechanisms that lead to the ablation of the metal from the foil and generation of acoustic waves for two of the regimes. Previously proposed desorption mechanisms for LIAD are presented along with the flaws associated with some of them. Various experimental parameters, such as the exact characteristics of the laser pulse and foil used, are discussed. The internal and kinetic energy of the neutral desorbed molecules are also considered. Our research group has been instrumental in the development and use of LIAD. For example, we have systematically examined the influence of many parameters, such as the type of the foil and its thickness, as well as the analyte layer's thickness, on the efficiency of desorption of neutral molecules. The coupling of LIAD with different instruments and ionization techniques allows for broad use of LIAD in our research laboratories. The most important applications involve analytes that cannot be analyzed by using other mass spectrometric methods, such as large saturated hydrocarbons and heavy hydrocarbon fractions of petroleum. We also use LIAD to characterize lipids, peptides, and oligonucleotides. Fundamental research on the reactions of charged mono-, bi-, and polyradicals with biopolymers, especially oligonucleotides, also requires the use of LIAD, as well as thermochemical measurements for neutral biopolymers. These are but a few of the uses of LIAD in our research group.

show abstract

Section: Generation Of Acoustic Waves For Laser-induced Acoustic Desomentioning

confidence: 99%

Section: Laser Pulse Irradiation and Ablationmentioning

confidence: 99%

See 1 more Smart Citation

Laser-Induced Acoustic Desorption Mass Spectrometry

Dow

Wittrig

Kenttämaa

2012

Eur J Mass Spectrom (Chichester)

View full text Add to dashboard Cite

show abstract

“…It is clear that the film undergoes pronounced structural modifications upon irradition at F LASER > 50 mJ/cm 2 . In the transient examination, enhanced scattering of the probing HeNe beam is observed between 60~100 ns, with a subsequent recovery of the reflectivity/transmission 24 . Therefore, "scatterers" must be formed which are suggested to be gaseous bubbles.…”

Section: °Kmentioning

confidence: 99%

“…Fain and Lin have tried to describe the ablation or explosive phenomenon by considering the electronic processes [ 24]. The main outcome of this work is the establishment of laser fluence and coverage dependent threshold conditions of the explosive regime.…”

Section: Phonon Avalanche Modelmentioning

confidence: 99%