Laser-Induced Explosion of Gold Nanoparticles: Potential Role for Nanophotothermolysis of Cancer

Letfullin, Renat R.; Joenathan, C.; George, Thomas F.; Zharov, Vladimir P.

doi:10.2217/17435889.1.4.473

Cited by 179 publications

(183 citation statements)

References 49 publications

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“…Among various synthesis methods, plant-mediated synthesis is preferred due to its cost effectiveness and environment-friendly nature [3,4]. GNP have applications in therapeutic [5], catalysis [2], immunoassay and immunosensing [6], diagnostic and drug delivery [7][8][9][10], analyte sensing [11][12][13], cancer cell diagnostics and selective photothermal therapy [14,15], photoacoustic imaging [16,17] and cancer treatment [18]. Various plant extracts have been explored for the synthesis of GNP, namely tamarind [19], Aloe vera [20], Pelargonium graveolens [21], Diopyros kaki [22], Eucalyptus camaldulensis and Pelargonium roseum [23], coriander [24], Scutellaria barbata [25], lemongrass [26], Datura metel, Carica papaya and Solanum melongena [27].…”

Section: Introductionmentioning

confidence: 99%

Characterisation of gold nanoparticles synthesised by leaf and seed extract ofSyzygium cuminiL.

Kumar

Yadav

2012

Journal of Experimental Nanoscience

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Here, Syzygium cumini leaf extract (LE) and seed extract (SE) were explored for the synthesis of gold nanoparticles (GNP). LE and SE as well as their polar (water) fractions showed potential for GNP synthesis. Comparative synthesis kinetics and morphological characterisation studies revealed the synthesis of smaller sized GNP by LE than SE. Only polar (water) fractions showed potential for GNP synthesis, which are smaller in size compared to their respective extracts. SE contained more polyphenols and biochemical constituents than LE and therefore, showed higher synthesis rate and bigger sized GNP. Atomic force microscope and scanning electron microscope analysis indicated that both extracts and their fractions catalysed the synthesis of spherical GNP. The average size of GNP synthesised by LE, leaf water fraction (LWF), SE and seed water fraction (SWF) were 24, 23, 35 and 32 nm, respectively. Fourier transform infrared analysis identified the biomolecules involved in the synthesis and stability of GNP. This study documented the potential of S. cumini for the synthesis of GNP in addition to silver nanoparticles (SNP). However, nature and types of polyphenols involved in GNP synthesis seem to be different from that involved in SNP synthesis. This might be the possible reason for smaller sized GNP that SNP.

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Section: Introductionmentioning

confidence: 99%

Characterisation of gold nanoparticles synthesised by leaf and seed extract ofSyzygium cuminiL.

Kumar

Yadav

2012

Journal of Experimental Nanoscience

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“…Similarly, use of short laser pulses, compared to continuous wave irradiation, allows less time for heat diffusion to surrounding host tissue during exposure for more localized bacterial damage and reduced nonspecific damage to normal tissue; this may also allow integration of detection through photoacoustic or other mechanisms into the treatment platform. 8,10,19 Using this approach, one research group reported a 95% killing of a methicillin-sensitive strain of S. aureus, in vitro, using laser pulses at 532 nm and a two-step nanoparticle targeting strategy involving binding of primary antibodies to the bacteria followed by treatment with secondary antibodies conjugated with gold nanospheres. 10 The purpose of the current study was to test the antibacterial effect of this laser-induced photothermal technique against both methicillin-sensitive and methicillinresistant S. aureus using a simplified, one-step method for targeting of the GNPs to the bacteria.…”

mentioning

confidence: 99%

Photothermal killing of Staphylococcus aureus using antibody-targeted gold nanoparticles

Millenbaugh¹,

Baskin²,

DeSilva³

et al. 2015

IJN

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Purpose The continued emergence of multidrug resistant bacterial infections and the decline in discovery of new antibiotics are major challenges for health care throughout the world. This situation has heightened the need for novel antimicrobial therapies as alternatives to traditional antibiotics. The combination of metallic nanoparticles and laser exposure has been proposed as a strategy to induce physical damage to bacteria, regardless of antibiotic sensitivity. The purpose of this study was to test the antibacterial effect of antibody-targeted gold nanoparticles combined with pulsed laser irradiation. Methods Gold nanoparticles conjugated to antibodies specific to Staphylococcus aureus peptidoglycan were incubated with suspensions of methicillin-resistant and methicillin-sensitive S. aureus (MRSA and MSSA). Bacterial suspensions were then exposed to 8 ns pulsed laser irradiation at a wavelength of 532 nm and fluences ranging from 1 to 5 J/cm 2 . Viability of the bacteria following laser exposure was determined using colony forming unit assays. Scanning electron microscopy was used to confirm the binding of nanoparticles to bacteria and the presence of cellular damage. Results The laser-activated nanoparticle treatment reduced the surviving population to 31% of control in the MSSA population, while the survival in the MRSA population was reduced to 58% of control. Significant decreases in bacterial viability occurred when the laser fluence exceeded 1 J/cm 2 , and this effect was linear from 0 to 5 J/cm 2 ( r 2 =0.97). Significantly less bactericidal effect was observed for nonfunctionalized nanoparticles or functionalized nanoparticles without laser activation. Conclusion Laser-activated nanoparticles targeted to S. aureus surface antigens significantly reduced the percentage of viable organisms and represents a promising new treatment modality that could be used either alone or as an adjunct to existing, conventional antibiotic therapy.

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“…Previous work studying the effect of pulsed laser on nanoparticles showed that exposure to irradiation resulted in fragmentation of particles and the generation of new extinction peaks associated with the new population [161,169,[171][172][173]. In this work, particles with diameters ranging from 20 to 50 nm with SPRs ranging from 550 to 750 nm were subjected to NIR pulsed light for 10 min at two different powers (350 and 700 J) [170].…”

Section: The Influence Of Laser Mode and Powermentioning

confidence: 98%

“…It has been reported that additional time for electron-phonon relaxation is created between lapses in pulses, which leads to better heat generation [167]. This is attributed to competition between the cooling of the lattice and the rate of the nanoparticle absorption of light [169]. In contrast, the application of a CW laser is believed to dissipate absorbed energy into its environment as the temperature of the nanoparticle increases due a relatively stable thermal relationship between the nanoparticles and solvent [99,164,165].…”

Section: The Influence Of Laser Mode and Powermentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Laser-Induced Explosion of Gold Nanoparticles: Potential Role for Nanophotothermolysis of Cancer

Abstract: Explosion of nanoparticles may be accompanied by optical plasma, generation of shock waves with supersonic expansion and particle fragmentation with fragments of high kinetic energy, all of which can contribute to the killing of cancer cells.

Cited by 179 publications

References 49 publications

Characterisation of gold nanoparticles synthesised by leaf and seed extract ofSyzygium cuminiL.

Characterisation of gold nanoparticles synthesised by leaf and seed extract ofSyzygium cuminiL.

Photothermal killing of Staphylococcus aureus using antibody-targeted gold nanoparticles

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

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