Laser-Induced Endovascular Thrombosis as a Possibility of Selective Vessel Closure

Boergen, K.-P.; Birngruber, R.; Hillenkamp, Franz

doi:10.1159/000265142

Cited by 23 publications

(9 citation statements)

References 13 publications

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“…The use of laser light ( 35 , 86 , 97 ) or a micropipette to puncture a vessel ( 75 ) ensures precise localization of the damage. One should realize that when chemical substances or laser light are used nonvascular structures may become damaged as well ( 13 , 33 , 97 ), which may indirectly influence the thromboembolic process. Microvascular thromboembolism, induced by one of the above‐mentioned methods, can be visualized in real time by using intravital microscopy ( 32 , 35 , 75 , 86 , 97 ), while at the same time local and systemic hemodynamic parameters can be quantified ( 75 , 76 , 97 ).…”

Section: Blood Platelets and Thromboembolismmentioning

confidence: 99%

Regulation of Microvascular Thromboembolism In Vivo

et al. 2005

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Atherothrombosis and embolization are main causes of morbidity and mortality in the Western world. To optimize treatment, better understanding of the factors involved in thromboembolism in vivo is needed. The course and outcome of a thromboembolic process are determined by the local balance between anti and prothrombotic factors. In healthy vessels, endothelial antithrombotic properties prevent blood platelets from interacting with the vessel wall. Upon vessel wall damage or endothelial activation, however, prothrombotic factors temporarily overrule the antithrombotic factors, leading to thrombus formation and embolization. According to this concept, thromboembolism ends when the balance is restored. Animal models on microvascular thromboembolism have provided evidence that the endothelium is eminently involved in the regulation of thromboembolism, and that shear forces are an important determinant of endothelial function. Therefore, in this review focus is on the endothelial regulation of platelet-vessel wall interactions during thromboembolism in vivo. Anti- and prothrombotic properties of vascular endothelium will be discussed, paying special attention to the endothelium-derived platelet inhibiting substances nitiric oxide (NO) and prostacyclin (PGl(2)) and to differences between arteriolar and venular endothelium. In addition, the involvement of shear forces in microvascular thromboembolic processes in vivo will be described

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Section: Blood Platelets and Thromboembolismmentioning

confidence: 99%

Regulation of Microvascular Thromboembolism In Vivo

et al. 2005

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“…Previous observations have suggested a preferen tial absorption of the 1,069 nm NYL in blood com ponents (Wharen et al, 1984;Eggert et al, 1985) and demonstrated the capacity of laser energy to obliterate small arterioles and venules by coagula tion and aggregation of blood elements (Toya et al, 1980;Boergen et al, 1981). Both of these charac teristics may also elicit reduced blood flow in the periphery of the laser lesion.…”

Section: Discussionmentioning

confidence: 93%

“…Boergen et al (1981) have shown the feasibility of small ves sel occlusion by the argon laser (10 mJ), which also is largely absorbed by hemoglobin. These effects are thought to be mediated through aggregation of damaged RBCs and the thrombogenicity of the ex posed subendothelial structures like collagen.…”

Section: Time (Min)mentioning

confidence: 99%

Cortical Microcirculation in a New Model of Focal Laser-Induced Secondary Brain Damage

Lindsberg

Frerichs

Burris

et al. 1991

J Cereb Blood Flow Metab

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Summary:To study the causes of spatial and temporal evolution of progressive neuroinjury in focal brain isch emia, models with consistent lesion topography are re quired. In such models, continuous monitoring of the mi crocirculation in a penumbral area undergoing progres sive damage could be possible. We used a fixed-pulse 0.0 s, 40 W) Nd-Y AG laser (NYL) to produced discrete brain lesions in rats and monitored the cerebral blood flow (CBF) with laser-Doppler flowmetry (LDF) in nonirradi ated areas directly adjacent to the maturing lesion. We also examined the time evolution of the lesion topography over a 4 day period. The lesion volume determined by histopathological methods increased from 3.1 ± 0.5 to 4.5 ± 0.5 mm3 (p < 0.05) during the first 2 h. Simultaneously, LDF indicated severe hypoperfusion (-60 ± 21%, p < 0.01) at a zone (I mm distance from the laser lesion)

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“…without damaging the wall was produced by Boergen et a1 [2]. Following these experimental researches with the Argon laser, endovascular thrombosis could be achieved in the normal small vessels at reduced flow rates, with lower energy rates.…”

Section: ) An Aggregation Of the Blood Cells Resulting In An Intralumentioning

confidence: 99%

Observations on the use of three laser sources in sequence (co₂‐argon‐nd: yag) in neurosurgery

1983

Lasers Surg Med

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In neurosurgical practice the laser can be considered an additional instrument to improve conventional techniques, or even a new method of treatment of some cerebral lesions. A complete laser surgery requires the association of three laser sources in combination. The CO2 laser is useful for cutting small lesions in important brain areas. Nd: YAG is particularly suitable for tumor surgery--allowing a deeper destruction with predictable effects associated with a more complete hemostasis. The combination Nd: YAG-Argon has clear indications for irradiation of the vessels.

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Laser-Induced Endovascular Thrombosis as a Possibility of Selective Vessel Closure

Cited by 23 publications

References 13 publications

Regulation of Microvascular Thromboembolism In Vivo

Regulation of Microvascular Thromboembolism In Vivo

Cortical Microcirculation in a New Model of Focal Laser-Induced Secondary Brain Damage

Observations on the use of three laser sources in sequence (co₂‐argon‐nd: yag) in neurosurgery

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Laser-Induced Endovascular Thrombosis as a Possibility of Selective Vessel Closure

Cited by 23 publications

References 13 publications

Regulation of Microvascular Thromboembolism In Vivo

Regulation of Microvascular Thromboembolism In Vivo

Cortical Microcirculation in a New Model of Focal Laser-Induced Secondary Brain Damage

Observations on the use of three laser sources in sequence (co2‐argon‐nd: yag) in neurosurgery

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Observations on the use of three laser sources in sequence (co₂‐argon‐nd: yag) in neurosurgery