The fragmentation of colloidal gold solution in pure water by nanosecond Nd:YAG laser radiation is found to be characterized by a threshold value of nanoparticle concentration, below which the colloidal solution remains stable. Above the threshold, large agglomerates of particles are intensively formed in the colloidal solution; this process manifests itself both in the absorption spectra and in the particle-size distribution. It is shown that the limiting concentration depends linearly on the average size of gold nanoparticles. The critical concentration for 7-nm nanoparticles is approximately 2 × 10 11 mL -1 , whereas the corresponding concentration for nanoparticles 17 nm in diameter is an order of magnitude lower: 2 × 10 10 mL -1 .