“…49 Photophysical studies on di-substituted 1,3-diphenyl-1,3propanedione compounds have shown that MeCN supports very slow exchange between tautomeric states, whereas protic solvents, including MeCN-water mixtures, enhance rates signicantly. 50,51 Water is oen used as a solvent or co-solvent in uorination reactions to aid solubility of Selectuor™. 28 Our studies show that the solubility limit of Selectuor™ in water is $500 mM, compared to $50 mM in MeCN.…”