Laser-evoked potentials: normative values

Truini, Andrea; Galeotti, F.; Romaniello, A.; Virtuoso, M.; Iannetti, Gian Domenico; Cruccu, G.

doi:10.1016/j.clinph.2004.10.004

Cited by 140 publications

(125 citation statements)

References 30 publications

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“…LEP amplitudes have been reported by other studies to significantly decrease with age, whereas latency and the interside difference of amplitude are not influenced by age. Similarly, gender was reported to have no effect on both latency and amplitude of LEP [45]. Our general finding of LEP amplitude increases according to stimulus intensity or decreases due to habituation are in good accordance with the results of other groups [29,44].…”

Section: Discussionsupporting

confidence: 81%

“…According to this criterion we identified 21 patients exceeding the amplitude criterion. Higher cut off criteria were reported by Beydoun et al [7] (28%), Hansen and Treede [19] (35%) or by Truini et al [45] (39%) using similar stimuli. Even if we apply the 40% criterion there were still 13 patients with pathological side-to-side amplitude differences.…”

Section: Discussionmentioning

confidence: 80%

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Dermatomal laser-evoked potentials: a diagnostic approach to the dorsal root. Norm data in healthy volunteers and changes in patients with radiculopathy

et al. 2006

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We conducted a cross-sectional study of 40 radiculopathy patients in comparison with norm data from healthy subjects using a new electrophysiological method. Early manifestations of dorsal root impairment escape objective diagnosis by conventional somatosensory-evoked potentials due to the overlapping innervation of the affected dermatome by thickly myelinated mechanoreceptive afferents projecting to adjacent intact roots. Evidence suggested less intersegmental overlap for thermonociceptive afferents rendering laser-evoked potentials (LEP) sensitive to monosegmental dorsal root damage. Therefore we used this new method to study acute manifestations of monosegmental dorsal root pathology. Dorsal root function was tested in 12 healthy subjects and 40 sciatica patients by intraindividual interside comparison. Mechanosensibility and thermosensibility were clinically investigated. LEP were induced by moderately painful laser stimuli. The LEP were evaluated by amplitude and latency of the averaged electroencephalogram. Normal interside differences of LEP for amplitude were ±22% (lower limb) and ±35% (upper limb) and ±15 to ±16% for latency. Twenty-six patients (65%) showed significant LEP changes, mainly amplitude decreases. Six of these patients exhibited latency prolongations. Clinical testing yielded more frequent pathological results for pain compared to mechanosensibility. The study confirmed our preliminary evidence of LEP sensitivity to objectively document dorsal root impairment in patients suffering from acute monosegmental radiculopathy. This result opens the perspective of electrophysiologically differentiating the presence or absence of dorsal root pathology in patients with similar clinical symptoms but possibly different prognoses, which require different therapies.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 80%

Dermatomal laser-evoked potentials: a diagnostic approach to the dorsal root. Norm data in healthy volunteers and changes in patients with radiculopathy

et al. 2006

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“…14 patients were affected by thoracic [12]. We then classified LEP signals as follows: standard signal = normal, pathologic signal = pathologic, absent signal = absent.…”

Section: The Samplementioning

confidence: 99%

“…The signal was considered absent when LEP = 0, whereas the cut off of LEP values were related to standard values (see reference Truini et al, 2005) [12].…”

Section: The Samplementioning

confidence: 99%

Laser evoked potential: Analysis of the methodology in post herpetic neuralgia

Caminiti¹,

Zaccaro²,

Truini³

et al. 2012

WJNS

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Background: Selective activation and the contemporary recording of A delta and C fibers from Yap laser on the scalp is a new neurophysiological assessment, allowing the selective activation of the nociceptive system. Objectives: To evaluate if the damage of the nociceptive system was related to post herptic nevralgia (PHN) development in a sample of 26 patients affected by Herpes zooster (HZ); secondly to assess if the impairment of thermal pathway and PHN development were related. Methods: Thirty-two patients were selected for the study, 26 of these were included in the study, whereas 6 were excluded because of cognitive impairment. All 26 study patients were submitted to LEP analysis at baseline (T0) and after six months (T1), and the correlation between clinical thermal disease and the development of PHN was monitored. Results: Pain duration was evidenced by the presence or absence of an instrumental signal in patients with acute HZ infection. There was total concordance between the absence of LEP signal and pain duration. The concordance between the clinical thermal disease and the pain duration was statistically significant for 43% of the sample. Conclusions: Our results suggested a possible role of LEP for PHN prognosis estimation; indeed, most patients affected by acute HZ, with absence of instrumental LEP signal had pain > 6 months. We also noted a significant (43% of cases) clinical concordance between the thermal pathway damage, the absence of instrumental signal and PHN development. Further studies are needed to address this issue.

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“…Useful pathophysiologic information in facial pain syndromes also comes from trigeminal LEPs, currently the most reliable and agreed method of investigating small fibre function [5,25,26].…”

Section: Findings In Facial Neuropathic Painmentioning

confidence: 99%

Neurophysiological assessment of craniofacial pain

2006

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This review deals with the diagnostic usefulness of neurophysiological testing in patients with craniofacial pain. Neurophysiological testing of trigeminal nerve function relies on trigeminal reflexes and laser-evoked potentials (LEPs). This review briefly describes the physiology of trigeminal reflexes and LEPs, reports normal values and highlights the neurophysiological abnormalities in the main clinical conditions.

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Laser-evoked potentials: normative values

Cited by 140 publications

References 30 publications

Dermatomal laser-evoked potentials: a diagnostic approach to the dorsal root. Norm data in healthy volunteers and changes in patients with radiculopathy

Dermatomal laser-evoked potentials: a diagnostic approach to the dorsal root. Norm data in healthy volunteers and changes in patients with radiculopathy

Laser evoked potential: Analysis of the methodology in post herpetic neuralgia

Neurophysiological assessment of craniofacial pain

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