Laser evoked potentials in Carpal Tunnel Syndrome

Tommaso, Marina de; Libro, Giuseppe; Difruscolo, Olimpia; Sardaro, Michele; Serpino, Claudia; Calabrese, Rita; Vecchio, Eleonora; Livrea, Paolo

doi:10.1016/j.clinph.2008.11.017

Cited by 16 publications

(5 citation statements)

References 25 publications

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“…De Tommaso et al found an increased pain threshold after laser stimulation of the second and third fingers, with normal pain thresholds at the fifth finger and hand dorsum levels in patients presenting with CTS symptoms and they suggested that their findings confirm the peripheral involvement of the median nerve nociceptive afferents 29. In a recent study, no significant differences were found in pain parameters, including pressure pain thresholds, warm and cold detection thresholds, and heat and cold pain thresholds, among patients with minimal, moderate, and severe CTS 22.…”

Section: Discussionmentioning

confidence: 93%

“…There are conflicting results about the involvement of Aδ and C fibers in neuropathic pain in CTS 28,29. De Tommaso et al found an increased pain threshold after laser stimulation of the second and third fingers, with normal pain thresholds at the fifth finger and hand dorsum levels in patients presenting with CTS symptoms and they suggested that their findings confirm the peripheral involvement of the median nerve nociceptive afferents 29.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between electrodiagnostic severity and neuropathic pain assessed by the LANSS pain scale in carpal tunnel syndrome

Gürsoy

Kolukisa²,

Yildiz³

et al. 2013

NDT

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ObjectiveThe aim of the study was to investigate the relationship between the presence of neuropathic pain assessed by the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale and electrophysiological findings in patients with carpal tunnel syndrome (CTS).MethodsWe studied 124 hands with idiopathic CTS with pain complaints involving hand and wrist. All hands were assessed by the LANSS with which a score of 12 or more is defined as pain dominated by neuropathic mechanisms. These hands were assigned to minimal, mild, moderate, severe, or extreme severe groups according to the results of the median nerve conduction studies.ResultsA LANSS score ≥ 12, suggestive of pain dominated by neuropathic mechanisms, was defined in 59 (47.6%) CTS hands. Pain intensity was significantly higher in CTS hands with a LANSS score ≥ 12 (P < 0.001). Among electrophysiological findings, compound muscle action potential amplitude was significantly lower in hands with a LANSS score ≥ 12 compared with hands with a LANSS score < 12 (P = 0.020). Severity of CTS was not significantly different between LANSS ≥ 12 and LANSS < 12 groups. Electrophysiological severity was significantly higher in CTS hands with evoked pain (P = 0.005) and allodynia (P < 0.001) in LANSS subscore analysis.ConclusionWe suggest that the presence of pain dominated by neuropathic mechanisms in CTS is not related to electrophysiological CTS severity. Neuropathic pain should be assessed carefully in patients with CTS, and an appropriate treatment plan should be chosen, taking into account the clinical and electrophysiological findings together with the true pain classification.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Relationship between electrodiagnostic severity and neuropathic pain assessed by the LANSS pain scale in carpal tunnel syndrome

Gürsoy

Kolukisa²,

Yildiz³

et al. 2013

NDT

View full text Add to dashboard Cite

show abstract

“…In patients with carpal tunnel syndrome, de Tommaso et al found a reduction of LEP amplitude after median-nerve territory stimulation even in patients with mild impairment and a positive correlation between the decrease of N2/P2 amplitude and severity of sensory symptoms. These authors concluded that the A␦fibre involvement in this common entrapment neuropathy is an early phenomenon and correlates with the severity of the disease [15].…”

Section: Studies Aiming To Demonstrate Small-fibre Involvementmentioning

confidence: 95%

Clinical usefulness of laser evoked potentials

Valeriani

Pazzaglia

Cruccu

et al. 2012

Neurophysiologie Clinique/Clinical Neurophysiology

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“…Multilevel random regression analyses were performed because of the hierarchical structure of the ERP data [33], [34]. The hierarchical structure of the current ERP data consist of single trials (level 1) that are clustered within individuals (level 2).…”

Section: Methodsmentioning

confidence: 99%

The Genetic Influence on the Cortical Processing of Experimental Pain and the Moderating Effect of Pain Status

et al. 2010

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BackgroundResearch suggests that the COMT Val158Met, BDNF Val66Met and OPRM1 A118G polymorphisms moderate the experience of pain. In order to obtain experimental confirmation and extension of findings, cortical processing of experimentally-induced pain was used.MethodA sample of 78 individuals with chronic low back pain complaints and 37 healthy controls underwent EEG registration. Event-Related Potentials were measured in response to electrical nociceptive stimuli and moderation by COMT Val158Met, BDNF Val66Met and OPRM1 A118G polymorphisms was assessed.ResultsGenetic variation did not have a direct effect on cortical processing of experimental pain. However, genetic effects (COMT Val158Met and BDNF Val66Met) on experimental pain were moderated by the presence of chronic pain. In the presence of chronic pain, the COMT Met allele and the BDNF Met allele augmented cortical pain processing, whilst reducing pain processing in pain-free controls. No significant effects were found concerning the OPRM1 A118G polymorphism.ConclusionsThe current study suggests that chronic experience of pain enhances genetic sensitivity to experimentally induced mildly painful stimuli, possibly through a process of epigenetic modification.

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Laser evoked potentials in Carpal Tunnel Syndrome

Cited by 16 publications

References 25 publications

Relationship between electrodiagnostic severity and neuropathic pain assessed by the LANSS pain scale in carpal tunnel syndrome

Relationship between electrodiagnostic severity and neuropathic pain assessed by the LANSS pain scale in carpal tunnel syndrome

Clinical usefulness of laser evoked potentials

The Genetic Influence on the Cortical Processing of Experimental Pain and the Moderating Effect of Pain Status

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