Laser-Evoked Potentials Habituation in Fibromyalgia

Tommaso, Marina de; Federici, Antonio; Santostasi, R.; Calabrese, Rita; Vecchio, Eleonora; Lapadula, Giovanni; Iannone, Florenzo; Lamberti, Paolo; Livrea, Paolo

doi:10.1016/j.jpain.2010.06.004

Cited by 106 publications

(115 citation statements)

References 49 publications

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“…For example, the main effect of the variable intensity was very significant in the N2 range and the P3 range. A similar observation could be made for linear habituation in the N2 range (De Tommaso, 2011).…”

Section: Discussion Of the Preliminary Findingssupporting

confidence: 78%

“…Only in the presence of depression did CLBP patients show a deficit in habituation. Interestingly, a recent study in fibromyalgia patients also found evidence for reduced habituation of the N200 vertex component, facilitated by the presence of symptoms of depression (De Tommaso, 2011). In conclusion, habituation seems to be different in chronic back pain patients compared to controls but is probably also influenced by factors, such as depression.…”

Section: Habituation and Pain-evoked Potentialsmentioning

confidence: 64%

See 1 more Smart Citation

The Use of Event-Related Potentials in Chronic Back Pain Patients

Vossen¹,

Vossen²,

Wetering³

et al. 2012

Low Back Pain

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Section: Discussion Of the Preliminary Findingssupporting

confidence: 78%

Section: Habituation and Pain-evoked Potentialsmentioning

confidence: 64%

The Use of Event-Related Potentials in Chronic Back Pain Patients

Vossen¹,

Vossen²,

Wetering³

et al. 2012

Low Back Pain

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“…30 Interestingly, a relatively recent study also showed that cerebral potentials recorded in response to repetitive noxious stimuli do not habituate (i.e., do not decrease in amplitude) in patients who suffer from fibromyalgia but do in healthy controls. 31 This neuronal effect was further tied to reduced habituation of experienced pain. The available scientific literature, together with our results suggest that the DLPFC may serve as a promising target area in the development of neuroimaging-based risk models and/ or targeted neurostimulation approaches to treatment.…”

Section: Discussionmentioning

confidence: 99%

Significance of Non-phase Locked Oscillatory Brain Activity in Response to Noxious Stimuli

Rouleau

Lagrandeur

Daigle

et al. 2015

Can. J. Neurol. Sci.

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Background: Although current pain-evoked electroencephalographic (EEG) studies provide valuable information regarding human brain regions involved in pain, they have mostly considered neuronal responses which oscillate in phase following a painful event. In many instances, cortical neurons respond by generating bursts of activity that are slightly out of phase from trial-to-trial. These types of activity bursts are known as induced brain responses. The significance of induced brain responses to pain is still unknown. Methods: In this study, 23 healthy subjects were given both non-painful and painful transcutaneous electrical stimulations in separate testing blocks (stimulation strength was kept constant within blocks). Subjective intensity was rated using a numerical rating scale, while cerebral activity tied to each stimulation was measured using EEG recordings. Induced brain responses were identified using a time frequency wavelet transform applied to average-removed single trials. Results: Results showed a pain-specific burst of induced theta activity occurring between 180 and 500 ms post-shock onset. Source current density estimations located this activity within the dorsolateral prefrontal cortex (DLPFC, bilaterally), however, only right DLPFC activity predicted a decrease in subjective pain as testing progressed. Conclusion: This finding suggests that non-phase locked neuronal responses in the right DLPFC contribute to the endogenous attenuation of pain through time. Perspective: This article presents neuroimaging findings demonstrating that, in response to pain, non-phase locked bursts of theta activity located in the right dorsolateral prefrontal cortex are associated with a progressive decrease in subjective pain intensity, which has potentially important implications regarding how humans endogenously control their experiences of pain. RÉSUMÉ: Signification de l'activité cérébrale induite en réponse aux stimuli douloureux. Contexte: Bien que les études électroencéphalographiques concernant la réponse à la douleur fournissent des informations précieuses sur les régions du cerveau humain impliquées dans la perception de la douleur, elles portent surtout sur les réponses neuronales qui oscillent en phase après un événement douloureux. Dans plusieurs cas, les neurones corticaux répondent en générant de l'activité qui est légèrement déphasée d'une fois à l'autre. Ce type d'activité est appelé réponse cérébrale induite. La signification des réponses cérébrales induites par un évènement douloureux demeure inconnue. Méthode: Cette étude porte sur 23 sujets sains soumis à des blocs séparés de stimulation électrique transcutanée non douloureuse et douloureuse. La force de la stimulation demeurait constante à l'intérieur de chacun des blocs de stimulation. Une échelle d'évaluation numérique a été utilisée pour estimer l'intensité de la stimulation ressentie par le sujet pendant que l'activité cérébrale liée à chaque stimulation était mesurée par enregistrement ÉEG. Les réponses cérébrales induites ont ét...

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“…This phenomenon has been studied to disentangle the neuronal substrates of behaviour, learn ing processes, and processing of CNS information in health and disease. [29][30][31][32] The majority of interictal evoked potential studies in patients with migraine support the notion that the migrainous brain is characterized by impaired habitu ation to repetitive stimuli. The habituation deficit is observed across several sensory modalities, and is usually accompanied by a normal to low amplitude of early responses in averaged data.…”

Section: Impaired Habituationmentioning

confidence: 92%

Altered processing of sensory stimuli in patients with migraine

et al. 2014

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| Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. To test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.

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Laser-Evoked Potentials Habituation in Fibromyalgia

Cited by 106 publications

References 49 publications

The Use of Event-Related Potentials in Chronic Back Pain Patients

The Use of Event-Related Potentials in Chronic Back Pain Patients

Significance of Non-phase Locked Oscillatory Brain Activity in Response to Noxious Stimuli

Altered processing of sensory stimuli in patients with migraine

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