Laser Doppler Perfusion Monitoring and Imaging

Nilsson, Gert; Salerud, Göran; Strömberg, Tomas; Wårdell, Karin; Larsson, Marcus

doi:10.1201/9780203008997.ch15

Cited by 45 publications

(53 citation statements)

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“…The assumptions are that ͑1͒ there is a fixed matrix of tissue scatterers, with all moving scatterers being RBCs; ͑2͒ the velocity distribution of the RBCs is independent of their spatial position; ͑3͒ the individual blood cells move independently; and ͑4͒ there is an RBC concentration low enough that each scattered photon encounters no more than one RBC. 22,23 These assumptions will clearly not be met in all cases, particularly when imaging blood vessels directly, but in the case of dermal perfusion, they should be reasonable. The difference between vessel and tissue imaging should also be considered when designing flow tubes in scattering phantom experiments to test perfusion measurements, as used by several groups.…”

Section: Discussionmentioning

confidence: 99%

Tissue perfusion measurements: multiple-exposure laser speckle analysis generates laser Doppler–like spectra

Thompson¹,

Andrews²

2010

J. Biomed. Opt.

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Abstract. Variations in skin perfusion are easily detected by laser speckle contrast maps, but a robust interpretation of the information has been lacking. We show that multiple-exposure laser speckle methods produce the same spectral information as laser Doppler methods when applied to targets with embedded moving scatterers. This enables laser speckle measurements to be interpreted more quantitatively. We do this by using computer simulation of speckle data, and by experimental measurements on Brownian motion and skin perfusion using a laser Doppler system and a multiple-exposure laser speckle system. The power spectral density measurements of the light fluctuations derived using both techniques are exactly equivalent. Dermal perfusion can therefore be measured by laser Doppler or laser speckle contrast methods. In particular, multiexposure laser speckle can be rapidly processed to generate a full-field map of the perfusion index proportional to the concentration and mean velocity of red blood cells.

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Section: Discussionmentioning

confidence: 99%

Tissue perfusion measurements: multiple-exposure laser speckle analysis generates laser Doppler–like spectra

Thompson¹,

Andrews²

2010

J. Biomed. Opt.

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“…The TLI signal is the summation of both AC and DC components from the photodetector and the perfusion signal represents the concentration of moving blood cells and their velocity. For details regarding signal processing see Nilsson et al [24,23]. During intracerebral measurements, the TLI signal represents the diffuse reflection of light which is related to the tissue type whereas the perfusion is related to relative changes in the tissue's microcirculation.…”

Section: Laser Doppler Perfusion Monitoringmentioning

confidence: 99%

A laser Doppler system for monitoring cerebral microcirculation: implementation and evaluation during neurosurgery

Rejmstad

Åkesson

Åneman

et al. 2015

Med Biol Eng Comput

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The aim of this study was to adapt and evaluate laser Doppler perfusion monitoring (LDPM) together with custom designed brain probes and software for continuous recording of cerebral microcirculation in patients undergoing neurosurgery. The LDPM system was used to record perfusion and backscattered light (TLI). These parameters were displayed together with the extracted heart rate (HR), pulsatility index (PI) and signal trends from adjustable time intervals. Technical evaluation was done on skin during thermal provocation. Clinical measurements were performed on ten patients undergoing brain tumour surgery. Data from 76 tissue sites were captured with a length varying between 10 s to 15 min. Statistical comparisons were done using Mann-Whitney tests. Grey and tumour tissue could be separated from white matter using the TLI-signal (p < 0.05). The perfusion was significantly higher in grey and tumour tissue compared to white matter (p < 0.005). LDPM was successfully used as an intraoperative tool for monitoring local blood flow and additional parameters linked to cerebral microcirculation (perfusion, TLI, heart rate and PI) during tumour resection. The systems stability opens up for studies in the postoperative care of patients with e.g. traumatic brain injury or subarachnoid haemorrhage.

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“…[10] Neither LDPM nor LDPI can be used for quantitative measuring of microvascular blood flow. The result can vary between individuals because of differences in the micro vascular anatomy and pigmentation.…”

Section: Ldpimentioning

confidence: 99%

“…The applications of laser doppler flowmetry includes pharmacological trials, allergy patch testing, wound healing, physiological assessments and skin disease research. [10] One of the most studied organs is the skin but internal organs such as muscles, kidneys, liver and heart among others has been investigated in different studies. [11] Lately research has been conducted by Sandberg et.…”

Section: Research Overviewmentioning

confidence: 99%

Laser-Doppler Flowmetry

På

2013

Encyclopedia of Pain

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Laser Doppler Perfusion Monitoring and Imaging

Cited by 45 publications

References 1 publication

Tissue perfusion measurements: multiple-exposure laser speckle analysis generates laser Doppler–like spectra

Tissue perfusion measurements: multiple-exposure laser speckle analysis generates laser Doppler–like spectra

A laser Doppler system for monitoring cerebral microcirculation: implementation and evaluation during neurosurgery

Laser-Doppler Flowmetry

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