Laser Doppler Flowmetry in Combined Needle Acupuncture and Moxibustion: A Pilot Study in Healthy Adults

Sandner‐Kiesling, Andreas; Litscher, Gerhard; Voit-Augustin, H.; James, Robert L.; Schwarz, Gerhard

doi:10.1007/pl00011353

Cited by 21 publications

(2 citation statements)

References 18 publications

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“…The thermal stimulation from moxibustion increases microcirculation [31] and promotes metabolism [32] by altering blood flow rate and cell membrane permeability. The heat from moxibustion also stimulates immune cells in the skin tissues, leading to immunomodulatory effects [33].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of electrical moxibustion for knee osteoarthritis: study protocol for a randomized controlled trial

Jung

Lee

et al. 2018

Trials

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BackgroundKnee osteoarthritis (KOA) is a significant health issue because it causes pain and functional limitation. Many studies have reported that moxibustion, a treatment in traditional Korean medicine, is effective in treating KOA. However, conventional moxibustion produces smoke, harmful gases, and odors that can adversely affect the eyes, skin, and throat. It is also difficult to control the intensity of stimulation in conventional moxibustion. An electrical moxibustion device was developed to circumvent these problems, but there are few studies of that device. We will evaluate the efficacy and safety of electrical moxibustion as a treatment for KOA, and compare it with traditional indirect moxibustion and usual care.MethodsThis is a multicenter, randomized, open, assessor-blinded, parallel-group clinical trial. A total of 138 eligible participants with KOA will be randomly allocated into three groups (electrical moxibustion, traditional indirect moxibustion, or usual care) with a 1:1:1 ratio. Participants in each moxibustion group will receive 12 sessions of moxibustion treatment at 6 acupoints (ST36, ST35, ST34, SP9, EX-LE4, SP10) plus up to 2 points of “ashi”, if needed, over a period of 6 weeks (2 sessions per week). A specifically designed device that provides thermal stimulation using electrical energy will be used for the electrical moxibustion group. Participants in the usual care group will receive usual treatment and self-care. The primary outcome measure is change in pain on a numerical rating scale (NRS) from week 1 to week 6. The secondary outcome measures are pain assessed on a visual analog scale (VAS), the Korean version of the Western Ontario and McMaster osteoarthritis index (K-WOMAC), patient global assessment (PGA), and the European quality of life five dimension five level scale (EQ-5D-5 L). Safety will be assessed by monitoring adverse events at each visit. Follow-up measurements will be performed at 12 weeks after baseline measurements.DiscussionThis trial will provide evidence on the efficacy and safety of electrical moxibustion as a treatment for KOA.Trial registrationClinicalTrials.gov, NCT03287570. Registered on 19 September 2017.Electronic supplementary materialThe online version of this article (10.1186/s13063-018-2514-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of electrical moxibustion for knee osteoarthritis: study protocol for a randomized controlled trial

Jung

Lee

et al. 2018

Trials

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“…This technique provides promise and opportunity to adapt the methodology in various fields of research for example in cerebral monitoring (stroke, injury … ), transplantation surgery (skin grafts, free flaps … ), vital organ monitoring (organ viability), tumor vascular research (angiogenesis) and peripheral vascular research (diabetes). Studies have shown that it is both highly sensitive and responsive to local blood perfusion and is also versatile and easy to use for continuous monitoring [1,2].…”

Section: Introductionmentioning

confidence: 99%

Determination of Capsaicin Induced Increase in Dermal Blood Flow Using Laser Doppler Flowmetry Technique

Khambam¹,

Naidu²,

Rani³

et al. 2011

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In the present study, we evaluated laser Doppler flowmetry technique using LDF100C (Biopac systems) by determining blood flow changes following acute application of capsaicin on 12 healthy human subjects. Capsaicin applied locally (topical application) at a dose of 0.075% produced significant increase in mean dermal blood flow from 31.4 ± 3.1 Blood Perfusion Units (BPU) to 115. 7 ± 24.6 Blood Perfusion Units (BPU) after 30 minutes, also there was significant difference in dermal blood flow change between placebo (32.1 ± 2.7 BPU) and capsaicin (115.7 ± 24.6 BPU) applica- tion. Capsaicin application produced significant percentage change in dermal blood flow by 291.0 ± 85.3% from baseline, while the change was insignificant with placebo (13.2 ± 7.4%). Therefore, it is suggested that this technique which is technically sound, non-invasive and inexpensive can be adopted in various fields of research to determine blood flow changes and this technique can also be utilized to determine the antagonists of the mediators involved in capsaicin induced vasodilatation

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An evaluation of the effect of a gastric ischemia–reperfusion model with laser Doppler blood perfusion imaging

Zhang

Wang

et al. 2006

Lasers Med Sci

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The objectives of this study are to establish a gastric ischemia-reperfusion model and test it using the laser Doppler blood perfusion imaging (LDPI) method and to evaluate the role of the LDPI technique in the measure of gastric blood circulation. The right gastric artery of the rat was clamped for 30 min and then reperfused. The LDPI was used to display the blood circulation of the whole gastric surface during this process. The blood flow perfusion image of the gastric surface was displayed clearly. After the right gastric artery was clamped, the blood flow perfusion on the gastric surface decreased very significantly until the clamp was loosened. Following reperfusion, the blood flow suddenly increased. Within the first 10 min, the blood-flow perfusion exceeded the level before the clamping and then gradually became smooth and steady. The right gastric artery is a main pathway for gastric blood supply. LDPI can display successfully the blood circulation state of the stomach and the course of ischemia-reperfusion of a large area with an image.

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Laser Doppler Flowmetry in Combined Needle Acupuncture and Moxibustion: A Pilot Study in Healthy Adults

Cited by 21 publications

References 18 publications

Efficacy and safety of electrical moxibustion for knee osteoarthritis: study protocol for a randomized controlled trial

Efficacy and safety of electrical moxibustion for knee osteoarthritis: study protocol for a randomized controlled trial

Determination of Capsaicin Induced Increase in Dermal Blood Flow Using Laser Doppler Flowmetry Technique

An evaluation of the effect of a gastric ischemia–reperfusion model with laser Doppler blood perfusion imaging

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