Laser doppler flowmetry. A new non-invasive measurement of microcirculation in intensive care?

Micheels, Jean; Aisbjorn, Bjarne; Sørensen, Bent

doi:10.1016/0300-9572(84)90056-x

Cited by 55 publications

(21 citation statements)

References 6 publications

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“…It cannot be definitely concluded from changes in skin capillary blood flow to vital organ blood flow and the present results must be interpreted carefully. In the critically ill, however, it has been suggested that monitoring of skin microcirculatory blood flow by laser Doppler technique may provide useful information related to total body perfusion [25,26].…”

Section: Measured Parameters and Data Pointsmentioning

confidence: 99%

Isolated circulatory response to intravenous administration of the ACE inhibitor enalaprilat.

Boldt

Knothe

Schindler

et al. 1994

Brit J Clinical Pharma

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The isolated vascular effects of intravenous administration of the angiotensin converting enzyme (ACE) inhibitor enalaprilat were investigated. Thirty male patients undergoing cardiopulmonary bypass (CPB) were studied. According to a randomized sequence, 0.04 mg kg‐1 enalaprilat (low‐dose, n = 10), 0.08 mg kg‐1 (high‐dose, n = 10) enalaprilat or saline solution as placebo (control group, n = 10) was given as an i.v. bolus during CPB. Changes in mean arterial pressure (MAP) and venous reservoir (RV) of the extracorporeal circulation were studied as indices of arterial resistance and venous capacitance. Mean arterial blood pressure (MAP) and peripheral vascular resistance (SVR) were significantly more reduced in the high‐dose enalaprilat group (MAP: ‐36 mm Hg after 9 min; SVR: ‐836 dyn s cm‐5) than in the low‐dose group (MAP: ‐13 mm Hg after 10 min). Volume of the reservoir (RV) decreased in both enalaprilat treated groups indicating additional (dose‐dependent) venous pooling effects of the substance (low‐dose: ‐ 300 ml; high‐dose: ‐520 ml; control group: ‐100 ml). Skin capillary blood flow measured by laser Doppler flowmetry (LDF) increased after injection of 0.04 mg kg‐1 enalaprilat, whereas it decreased significantly when MAP fell markedly in patients treated with high‐dose enalaprilat. I.v. enalaprilat had dose‐dependent vasodilating properties in the arterial and venous vessel system indicating reduction in pre‐ and afterload. Microcirculation in both enalaprilat treated groups improved as long as reduction in blood pressure was not limited.

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Section: Measured Parameters and Data Pointsmentioning

confidence: 99%

Isolated circulatory response to intravenous administration of the ACE inhibitor enalaprilat.

Boldt

Knothe

Schindler

et al. 1994

Brit J Clinical Pharma

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“…An accuracy of 92% was obtained. Despite these encouraging results, the principle disadvantage remained the use of a heated probe in direct contact with one or more points of the burn surface [46][47][48]. Only part of the total burn surface therefore was assessed using this method with the consequent risk of an erroneous diagnosis as a result of sampling error [46,49].…”

Section: Laser Doppler Imagingmentioning

confidence: 99%

Assessment of burn depth and burn wound healing potential

Monstrey

Hoeksema

Verbelen

et al. 2008

Burns

370

266

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“…Studies of cutaneous and subcutaneous blood flows after injection of benzodiazepine show an increase in the surface cutaneous thermal clearance as well as a stability of the deep thermal clearance, corresponding to an increase in cutaneous blood flow with no deterioration of subcutaneous blood flow [30,31]. In another study, LDF also reveals an increase in cutaneous blood flow among anaesthetised and hypothermic patients compared to control subjects [32]. …”

Section: Discussionmentioning

confidence: 99%

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et al. 2006

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Introduction Sedation is widely used in intensive care unit (ICU) patients to limit the risk of pulmonary barotrauma and to decrease oxygen needs. However, adverse effects of sedation have not been fully evaluated; in particular, effects of benzodiazepine and opiates on microcirculation have not been extensively studied. The aim of this study was to evaluate the microcirculatory effects of a sedation protocol commonly prescribed in the ICU.

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Laser doppler flowmetry. A new non-invasive measurement of microcirculation in intensive care?

Cited by 55 publications

References 6 publications

Isolated circulatory response to intravenous administration of the ACE inhibitor enalaprilat.

Isolated circulatory response to intravenous administration of the ACE inhibitor enalaprilat.

Assessment of burn depth and burn wound healing potential

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