Laser Doppler blood flowmeter as a useful instrument for the early detection of lower extremity peripheral arterial disease in hemodialysis patients: an observational study

Ishii, Takeo; Takabe, Shizuka; Yanagawa, Yuki; Ohshima, Yuko; Kagawa, Yusuke; Shibata, Atsuko; Oyama, Kunio

doi:10.1186/s12882-019-1653-y

Cited by 22 publications

(19 citation statements)

References 34 publications

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“…Moreover, volumetric CT perfusion has recently shown promising results in the assessment of PAD before and after revascularization [ 50 , 51 ], while a new MR perfusion protocol reliably differentiated patients with PAD from healthy controls [ 52 ]. The laser Doppler blood flowmeter is another useful noninvasive tool for detecting PAD at an early stage by recording skin perfusion deterioration [ 53 ].…”

Section: Diagnosismentioning

confidence: 99%

Approaches to Peripheral Artery Disease in Diabetes: Are There Any Differences?

Achim

Stanek

Homorodean

et al. 2022

IJERPH

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Peripheral artery disease (PAD) increases the risk of diabetes, while diabetes increases the risk of PAD, and certain symptoms in each disease increase the risk of contracting the other. This review aims to shed light on this harmful interplay between the two disorders, with an emphasis on the phenotype of a patient with both diabetes and PAD, and whether treatment should be individualized in this high-risk population. In addition, current guideline recommendations for the treatment of PAD were analyzed, in an attempt to establish the differences and evidence gaps across a population suffering from these two interconnected disorders.

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Section: Diagnosismentioning

confidence: 99%

Approaches to Peripheral Artery Disease in Diabetes: Are There Any Differences?

Achim

Stanek

Homorodean

et al. 2022

IJERPH

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“…In relation to the case series presented, the patient with the worst ACh response by Day 14 (Case 3) later went on to develop secondary fungemia as well as require antihypertensive therapies. While this single instance should not be interpreted as cause and effect, use of such devices to prospectively predict peripheral artery disease in adults has been utilized and one could conceive a similar application in pediatrics during and after critical illness (27).…”

Section: Discussionmentioning

confidence: 99%

Case report: Temporal alterations in vascular function during the first 2 weeks of pediatric septic shock

Wijers

Stark²

2022

Front. Pediatr.

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IntroductionDuring sepsis and septic shock, the host's immune systems generate an overwhelming and often, detrimental, inflammatory response. Part of this response results in significant alterations in blood flow and vasomotor tone regulated in part by endothelial and vascular smooth muscle cells. Here, we report on a series of 3 pediatric patients for whom vascular response was assessed by laser doppler perfusion coupled to iontophoresis over the first 2 weeks after hospitalization for septic shock to demonstrate similarities and dissimilarities in the vascular response.Case PresentationsA 12-year-old male with a history of Burkitt's Lymphoma, a 21-year-old male with congenital porencephaly and epilepsy, and a 7-year-old male with no significant past medical history all were admitted to a tertiary care children's hospital with a diagnosis of septic shock requiring vasoactive infusions to maintain mean arterial blood pressure. Non-invasive laser doppler perfusion coupled with iontophoresis of either acetylcholine (endothelial-dependent response) or sodium nitroprusside (endothelial-independent response) was performed on hospital days 1, 3, 7, and 14. Variability and heterogeneity were demonstrated by the temporal assessments of the vascular response to sodium nitroprusside, but all three patients showed significant similarity in the temporal responsiveness to acetylcholine.ConclusionAssessment of baseline and temporal responsiveness to endothelial-dependent vascular reactivity may provide a predictable timeline to the resolution of pediatric septic shock.

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“…These beams penetrate the skin, hit red blood cells in the vasculature, and are dispersed. The laser beams are then converted to scattered light by frequency variation (Doppler shift), which are recognized as electrical signals by a photodetector [12][13][14][15][16]. In this study, a distal embolism event was defined as the occurrence of reduced blood flow in the first or fifth toe around the time of DCB treatment (DEL).…”

Section: Evaluation Of Blood Flow Patternsmentioning

confidence: 99%

Clinical outcome of the patients with femoropopliteal artery disease after endovascular therapy: focused on drug-coated-balloon-related distal embolism detected by laser doppler flowmetry

Fukai¹,

Nakagami²,

Hamaoka

et al. 2021

Cardiovasc Interv and Ther

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Several trials have shown that paclitaxel drug-coated balloons (DCBs) significantly reduce restenosis rates. However, some reports have shown distal embolisms occurring after DCBs. No study has analyzed the clinical outcomes of patients with DCB-induced distal embolism. This study aimed to investigate the clinical outcomes of DCB-induced distal embolism in patients with femoropopliteal artery disease. Between February 2018 and April 2019, consecutive patients (n = 32) who presented with de novo femoropopliteal artery disease and underwent endovascular therapy using DCB were retrospectively reviewed in a single-center study. Patients were divided into two groups based on whether distal embolism was detected using laser doppler flowmetry (DEL group) or not (non-DEL group). Baseline characteristics and 1-year clinical outcomes were compared between the groups. DEL was found in 44% of limbs (DEL group: n = 15, non-DEL group: n = 19). Below-the-knee arterial runoff ≤ 1 (p = 0.033), popliteal lesion (p = 0.044), ambulation difficulty (p = 0.021), and previous history of coronary artery disease (p = 0.013) were identified as predictive factors of DEL. Procedural factors, reference vessel diameter, lesion length, and total drug amount were not predictive of DEL. The overall target lesion restenosis (TLR) rate was 17.4% (n = 5). The TLR rate was not significantly different between the DEL and non-DEL groups (13.3% vs. 15.8%, p = 0.55). Severe calcification was the only significant factor for TLR (4.2% vs. 40.0%, p = 0.02). Among patients with femoropopliteal disease, there was no difference in 1-year clinical outcome between patients who underwent DEL and those who did not.

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Laser Doppler blood flowmeter as a useful instrument for the early detection of lower extremity peripheral arterial disease in hemodialysis patients: an observational study

Cited by 22 publications

References 34 publications

Approaches to Peripheral Artery Disease in Diabetes: Are There Any Differences?

Approaches to Peripheral Artery Disease in Diabetes: Are There Any Differences?

Case report: Temporal alterations in vascular function during the first 2 weeks of pediatric septic shock

Clinical outcome of the patients with femoropopliteal artery disease after endovascular therapy: focused on drug-coated-balloon-related distal embolism detected by laser doppler flowmetry

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