Laser CO2 vaporization for high-grade cervical intraepithelial neoplasia: a long-term follow-up series

Fallani, Maria Grazia; Penna, Carlo; Fambrini, Massimiliano; Marchionni, M

doi:10.1016/s0090-8258(03)00440-2

Cited by 22 publications

(12 citation statements)

References 12 publications

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“…The presence in our study of a high rate of positive margins (> 50%), despite of a recurrence rate equal to that described in literature (< 8%), is justifiable considering the characteristics of the technique used by the working group of the University of Florence, already described in previous studies [22]. The CO 2 laser, instead of LEEP, allows to taylor the treatment according to the size of the lesion and to minimize the volume of the excised cone, because the intervention always includes a second destructive moment characterized by vaporization of the crater base and walls, reaching more millimeters of depth.…”

Section: Doi: 107243/2052-6210-1-3supporting

confidence: 65%

The efficacy of long term follow-up and CO2 laser conization as conservative management in patients with cervical cancer stage FIGO IA1

Fallani¹,

Pieralli²,

Lozza³

et al. 2013

Gynecol

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Background: Patients with FIGO (International Federation of Gynaecologists and Obstetricians) stage IA1 cervical squamous carcinoma can be treated conservatively with conization only as alternative to a hysterectomy. The aim of this study was to evaluate the efficacy of laser CO 2 excision as therapeutical method for stage IA1 cervical squamous carcinoma. Methods: Sixty patients were submitted to CO 2 laser conization with histologic diagnosis of squamous carcinoma stage FIGO IA1 and then submitted to follow-up with PAP smear, colposcopy and biopsy. Prognostic risk factors for relapse were evaluated with univariate analysis. Results: Conservative management with laser therapy was effective in more than 90% of the patients. When disease persistence was detected (7%), patients underwent repeated laser CO 2 conization and followed-up without demolitive intervention. The risk of disease progression in the case series was 1.8%. Univariate analysis revealed that only depth of stromal invasion was a significant risk factor for relapse (P<0.04). Moreover, depth of stromal invasion between 1-3 mm was the only prognostic factor for relapse with specificity 78%, sensitivity 75% and likelihood positive ratio 3,47. Conclusion: Laser CO 2 conization alone appeared to be an effective and safe treatment for patients with Cervical Cancer Stage FIGO IA1 if careful post-treatment follow-up was guaranteed. The deph of stromal invasion has been confirmed as the most important risk and prognostic factor to be evaluated for disease relapse.

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Section: Doi: 107243/2052-6210-1-3supporting

confidence: 65%

The efficacy of long term follow-up and CO2 laser conization as conservative management in patients with cervical cancer stage FIGO IA1

Fallani¹,

Pieralli²,

Lozza³

et al. 2013

Gynecol

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“…6 Not only does the combination increase the sensitivity of cytology but it also increases the specificity of colposcopy. We recommend that all patients after laser ablation should undergo Pap smears combined with colposcopy assessment and biopsy of atypical lesions at six months post-treatment.…”

Section: Discussionmentioning

confidence: 99%

Is colposcopy needed following laser ablation for dysplasia?

Tan

Thompson

Neesham

et al. 2006

Aust NZ J Obst Gynaeco

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“…Loop electrosurgical excisional procedure (LEEP) has become the most common form of conisation due to its easy technique, high success rate, low morbidity and comparable success rate to cold knife conisation (Wright et al . 1992; Fallani et al . 2003).…”

Section: Cervical Intraepithelial Neoplasiamentioning

confidence: 99%

Management of precancerous lesions prior to conception and during pregnancy: a narrative review of the literature

Jy¹,

Baştu²,

Gungor-Ugurlucan³

2012

European Journal of Cancer Care

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Special considerations aiming at preserving reproductive function have to be implemented when treating young patients with precancerous lesions of the lower genital tract. These high-grade lesions may progress into invasive cancer if left untreated. Currently, there are limited data on the impact of vulvar and vaginal precancerous lesions on fertility and its management during pregnancy. However, management and outcomes for cervical lesions have been extensively reported. The main approach for vulvar and vaginal lesions are maintaining anatomical function and cosmetics; whereas, treatment options for cervical precancerous lesions range from observation, cryotherapy or the more aggressive conisation. Gestational age is the most important factor in determining expectant management or surgical intervention. This narrative review draws attention to the relevant aspects of precancerous lesions of the lower genital tract, the potential effects and management prior to conception and during pregnancy.

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Laser CO2 vaporization for high-grade cervical intraepithelial neoplasia: a long-term follow-up series

Cited by 22 publications

References 12 publications

The efficacy of long term follow-up and CO2 laser conization as conservative management in patients with cervical cancer stage FIGO IA1

The efficacy of long term follow-up and CO2 laser conization as conservative management in patients with cervical cancer stage FIGO IA1

Is colposcopy needed following laser ablation for dysplasia?

Management of precancerous lesions prior to conception and during pregnancy: a narrative review of the literature

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