Laser cartilage reshaping in an in vivo rabbit model using a 1.54 μm Er:Glass laser

Mordon, Serge; Wang, Tao; Fleurisse, Laurence; Creusy, Colette

doi:10.1002/lsm.20029

Cited by 42 publications

(78 citation statements)

References 33 publications

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“…Experimental results [6,55] indicate the conditions for in vivo laser reshaping are different from those found in vitro. Furthermore, histological examination of ear cartilage undergoing laser reshaping indicates a new cartilage of hyaline type replaces the old partially damaged irradiated cartilage of elastic type.…”

Section: Animal Studies Of Laser Reshaping Of Cartilagementioning

confidence: 89%

Laser reshaping and regeneration of cartilage

et al. 2007

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Demonstration of laser-induced stress relaxation in cartilage in 1992 led to the development of a novel laser surgical procedure in otolaryngology for the non-ablative reshaping of cartilage. Follow-up studies found that non-destructive laser irradiation may activate regeneration processes in cartilaginous tissue. Ongoing studies seek to characterize the physical, chemical and biological processes and mechanisms involved in the reshaping and regeneration of deformed and diseased cartilage under moderate laser heating. A theoretical model is developed considering laser-induced stress relaxation in cartilage as a process of micropore formation. Results obtained provide scientific and engineering data for development of novel laser surgical procedures for correction of the nasal septum and treatment of spine disc cartilage diseases. This review is aimed to present state of art and recent results in laser -induced reshaping and regeneration of cartilage.Histological cross-section of porcine nasal septal cartilage after laser reshaping using 1.56 µm laser radiation with power of 1.5 W, spot diameter 2 mm, exposure time of 5 s. Stained with Hematoxylin and Eosin, ×400

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Section: Animal Studies Of Laser Reshaping Of Cartilagementioning

confidence: 89%

Laser reshaping and regeneration of cartilage

et al. 2007

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“…Recently, Mordon et al [4] have demonstrated that rabbit ear cartilage can be reshaped in situ with an Er:Glass laser (1.54 mm). The possibility of obtaining a permanent reshaping of rabbit ear with no skin incision and no skin perforation was especially impressive since it is usually considered that rabbit ear are not a suitable model because the rabbit ear is supported by muscles that are far more substantial than those of humans [5].…”

mentioning

confidence: 99%

Correction of ear malformations by laser‐assisted cartilage reshaping (LACR)

Trelles

Mordon

2006

Lasers Surg Med

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“…However, further studies will have to look into this. Over expression of HSP following laser irradiation has been well documented in the fields of dermatology, ophthalmology and more recently in cartilage reshaping [13,14,[46][47][48]. In fact, some HSP were identified in bone through immunolocalization in a paper by Tiffee et al [49].…”

Section: Discussionmentioning

confidence: 99%

Laser preconditioning of calvarial bone prior to an X‐ray radiation injury: A preliminary in vivo study of the vascular response

et al. 2008

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Background and Objectives: Thermal preconditioning prior to injury induces a cytoprotective effect on soft tissues and promotes their recovery. Lasers are an adequate tool to generate controlled and reproducible heat. X-ray irradiation induces a chronic antiangiogenic effect on bone, affecting its healing and remodeling processes. The aim of this study was to investigate the effect of laser preconditioning on the re-vascularization of X-ray irradiated bone. Materials and Methods: A bone chamber was implanted onto the calvaria of rabbits to study the vascularization process. Digital pictures were taken of the vascular plexus at the target bone site using a modified digital camera. Vascular density (VD) was determined using image processing. It was defined as the ratio of blood vessel pixels to the total number of pixels to the region of interest. Laser preconditioning was performed with a diode laser (810 nm, 2 W, 3 seconds, 48 J/cm 2 , 4 mm). A 12-week follow-up study was performed on 20 rabbits divided into four groups: #1: control group (n ¼ 5); #2: laser irradiation alone (n ¼ 5). #3: X-ray radiation (18.75 Gy) alone (n ¼ 5), #4: laser preconditioning 24 hours prior to X-ray radiation (n ¼ 5). Results: VD remained stable during the 12-week follow up for group #1. No significant difference was observed between laser irradiation group (#2) and control group (#1) (P > 0.5). The angiolytic action of X-ray radiation was confirmed in groups #3 and #4, which were statistically different from group #1 (P<0.001). However, the decrease of the vascularization was limited in group #4 highlighting a different evolution between group #3 and #4 (P<0.05). These results were confirmed by histological analysis. Discussion and Conclusion: The bone chamber is an effective reproducible method for the longitudinal analysis of the dynamics of vascularization. Our findings have shown that laser preconditioning is capable of preserving vascularization in an X-ray irradiated bone site, thus suggesting a novel approach for promoting the healing of bone tissue in which the vascular supply has been damaged.

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Laser cartilage reshaping in an in vivo rabbit model using a 1.54 μm Er:Glass laser

Cited by 42 publications

References 33 publications

Laser reshaping and regeneration of cartilage

Laser reshaping and regeneration of cartilage

Correction of ear malformations by laser‐assisted cartilage reshaping (LACR)

Laser preconditioning of calvarial bone prior to an X‐ray radiation injury: A preliminary in vivo study of the vascular response

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