Laser biostimulation of cartilage: in vitro evaluation

Torricelli, Paola; Giavaresi, Gianluca; Fini, Milena; Guzzardella, Gaetano Antonio; Morrone, G; Carpi, Angelo; Giardino, Roberto

doi:10.1016/s0753-3322(00)00025-1

Cited by 48 publications

(44 citation statements)

References 15 publications

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“…In vivo and in vitro studies have shown the biological effects of laser therapy such as an increase in local microcirculation, activation of the lymphatic system, and proliferation of epithelial cells and fibroblasts. [17][18][19][20] Pinheiro and Gerbi 12 discussed the positive effects of laser irradiation on the cell membrane and mitochondria and its influence on adenosine triphosphate (ATP) production. Bone tissue is a major source of angiogenic and endothelial factors, as well as bone morphogenetic proteins, which are essential for osteogenesis and angiogenesis.…”

Section: Low-level Laser Therapy and Calcitonin In Bone Repairmentioning

confidence: 99%

Effect of Low-Level Laser Therapy and Calcitonin on Bone Repair in Castrated Rats: A Densitometric Study

Nascimento

Cardoso

Ribeiro

et al. 2010

Photomedicine and Laser Surgery

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Objective: To investigate the healing of bone defects in male rats treated with salmon calcitonin, low-level laser therapy (LLLT), or both. Background: Healing of bone defects still represents a challenge to health professionals in several areas. In this article, the effect of calcitonin in combination with LLLT on bone repair was studied. Densitometry was used as a valuable tool for the measurement of bone regeneration. Methods: Sixty male Wistar rats underwent bilateral castration surgery before the creation of a surgical bone defect. The animals were randomly divided into four groups: control, treated with calcitonin (Ca), treated with LLLT (La), and treated with calcitonin and LLLT (CaLa). Groups Ca and CaLa received 2 IU=kg of synthetic salmon calcitonin intramuscularly three times a week. Groups La and CaLa received laser therapy using a gallium-aluminum-arsenide laser (10 mW, 20 J=cm 2 , wavelength 830 nm). Control animals were submitted to sham irradiation. The animals were sacrificed 7, 14, and 21 days after surgery, and bone defects were analyzed using densitometry. Results: The CaLa group had a higher degree of bone regeneration 14 and 21 days after surgery. Conclusions: The La and CaLa had significantly higher bone mineral density than the control and Ca groups.

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Section: Low-level Laser Therapy and Calcitonin In Bone Repairmentioning

confidence: 99%

Effect of Low-Level Laser Therapy and Calcitonin on Bone Repair in Castrated Rats: A Densitometric Study

Nascimento

Cardoso

Ribeiro

et al. 2010

Photomedicine and Laser Surgery

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“…Evidence abounds that treatment with polychromatic or monochromatic light (phototherapy), in particular light and/or infrared radiation with less than 200 mW-cm À2 irradiance and 600-1,000 nm wavelength [1][2], promotes the repair processes of skin [3][4][5][6][7][8][9][10][11][12], ligament [13][14][15][16], tendon [17][18][19][20], bone [13,[21][22][23][24], and cartilage [13,[25][26][27][28][29] in experimental animal wounds and human ulcers of various etiologies [30][31][32][33]. There is evidence that phototherapy advances tissue repair by promoting fibroblast proliferation [34][35][36][37][38][39][40][41][42][43][44], synthesis of collagen and other components of tissue [45]…”

Section: Introductionmentioning

confidence: 99%

Phototherapy promotes healing of chronic diabetic leg ulcers that failed to respond to other therapies

et al. 2009

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“…However, some reports [14,22] have suggested that LLLT could improve bone matrix production due to improved vascularization and anti-inflammatory effects. These would result in an increase in both the release of mediators and microvascularization, which would accelerate bone healing.…”

Section: Discussionmentioning

confidence: 99%

The recover from the excision in head and neck of femoral after therapy with low level laser

Pacheco‐Soares

Gusmao²,

Ferreira³

et al. 2012

JBiSE

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Degenerative articulate diseases, resulting from dysplasia and aseptic necrosis of the femoral head and neck, chronic dislocation of the femur and osteoarthrosis, are often treated surgically by an excision in the femoral head and neck. This procedure entails the formation of a false fibrous articulation, providing pain relief. The action of low level laser therapy (LLLT) has been described in orthopedic applications, to repair both bone and articular tissue. LLLT has demonstrated favorable results in vitro and in vivo in stimulating bone repair. A diode laser, 650 nm, with a potency of 30 mW, was used trans-surgically to irradiate. A diode laser (780 nm and the potency of 40 mW) was used on the skin for post-surgery applications. For the experiment, 10 clinically normal New Zealander rabbits underwent surgery and were then divided into two groups, one submitted to irradiation and the other kept for sham. Fifteen days after the surgery, samples of the newly formed tissue were collected from both groups, for macroscopic evaluation of the fibrous pseudo-articulation forming process on the irradiated and sham groups. The macroscopic and microscopic appearance of the samples, suggest that the utilization of the LLLT in the formation of fibrous pseudo-articulation was effective in accelerating the cicatrization process and in improving the quality of the formed tissue.

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Laser biostimulation of cartilage: in vitro evaluation

Cited by 48 publications

References 15 publications

Effect of Low-Level Laser Therapy and Calcitonin on Bone Repair in Castrated Rats: A Densitometric Study

Effect of Low-Level Laser Therapy and Calcitonin on Bone Repair in Castrated Rats: A Densitometric Study

Phototherapy promotes healing of chronic diabetic leg ulcers that failed to respond to other therapies

The recover from the excision in head and neck of femoral after therapy with low level laser

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