The interaction of a high-intensity laser pulse with a plasma density channel preformed in a gas jet target has been studied. At neutral densities below 3.0 3 10 19 cm 23 a strong interaction between the pulse and the channel walls was observed, there was clear evidence of pulse confinement, and the laser irradiance was significantly increased compared to an interaction with neutral gas. At higher gas densities, however, the radial uniformity and length of the channel were both found to be adversely affected by refractive defocusing of the prepulse used to generate the channel.[S0031-9007(98)06338-8] PACS numbers: 52.40.Nk, 52.35.Tc, 52.50.Jm The propagation of intense laser pulses through preformed plasmas is an important area of study for many topical applications of laser produced plasmas, such as the laser particle accelerator [1], x-ray lasers [2], high harmonic generation, and the fast ignitor scheme [3]. These applications generally require an ultrashort high power laser pulse to interact with a neutral gas or plasma at high density (with n e . 0.01n c where n e and n c are the electron and critical density, respectively) and high irradiance ͑10 14 10 19 W cm 22 ͒ over distances ranging from a few mm to several cm. At extremely high laser irradiance ͑.10 18 W cm 22 ͒ self channeling due to relativistic and ponderomotive effects can greatly enhance the propagation length [4]. However, the interaction length can still be increased for applications requiring lower laser irradiance by focusing a low energy prepulse to form a plasma waveguide or channel [5][6][7][8]. To date most experiments using this scheme have been carried out at low densities where the length of the guiding channel is limited by the depth of focus of the preforming laser. In fact, guiding over 203 the diffraction limited focal depth has been observed by using an axicon to maximize the length of the plasma channel [6]. Applying this result to higher plasma densities is problematic for short (1-10 ps) prepulses because as the density increases the length of the channel will be limited by ionization defocusing of the preforming pulse [9,10] not diffraction. There is presently little or no information on the effect of ionization defocusing on the formation of preformed density channels using short prepulses. In addition there are very few direct measurements of how the second pulse interacts with and modifies the channel.This Letter describes the first experimental studies of the interaction of intense laser pulses with plasma channels in the strongly refractive density regime where ionization defocusing influences both the formation of the channel itself and the subsequent propagation of intense pulses through it. In these experiments a 1 mm, 3 ps, laser pulse was focused onto the edge of a neon gas jet with atomic density .1 3 10 19 cm 23 at a vacuum intensity of 1 3 10 18 W cm 22 . Quantitative measurements of the electron density profiles produced by focusing the laser pulse either into the neutral gas or preformed density channel were ...