Laser‐Based Printing: From Liquids to Microstructures

Armon, Nina; Greenberg, Ehud; Edri, Eitan; Nagler‐Avramovitz, Ornit; Elias, Yuval; Shpaisman, Hagay

doi:10.1002/adfm.202008547

Cited by 29 publications

(28 citation statements)

References 183 publications

(909 reference statements)

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“…Worthwhile noting, due to the simple design of the wavelength‐scaled switching element (a DOE), the high‐precision 3D printing technologies such as TPP and SLA [ 24,25,27,28 ] can be used to manufacture the considered mesoscale elements operating in the optical or THz spectral ranges. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

Wavelength‐Scale Photonic Space Switch Proof‐Of‐Concept Based on Photonic Hook Effect

2021

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The proof‐of‐concept of a new wavelength‐scaled all‐optical two‐channel switch based on the photonic hook phenomenon is proposed and demonstrated. By means of the numerical finite‐difference time‐domain simulations, several prototypes of such devices are considered based on dielectric microstructures with broken symmetry of both geometric shape and optical properties without the use of micromechanical devices or non‐linear materials. Due to the unique property of the photonic hook to change its curvature depending on the optical wavelength, the proposed switch is a promising candidate for the implementation of optical switching in modern optoelectronics and miniature “on‐chip” devices. Optical isolation that is close to 20 dB is discovered at the wavelengths of 1.5 and 1.9 µm for a dielectric Janus microbar‐based switch with linear dimensions of about (6λ)3 (λ is the wavelength of the incident plane wave).

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Section: Discussionmentioning

confidence: 99%

Wavelength‐Scale Photonic Space Switch Proof‐Of‐Concept Based on Photonic Hook Effect

2021

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“…However, challenges associated with droplet inconsistency, low cell density, easy nozzle blockage, and physical stresses on cells limit the range of this technique’s applicability. Alternatively, laser-based bioprinting also enables droplet-based printing for single cell manipulation or 3D spheroid formation[ 116 , 117 ]. Using the platform, laser direct-write, Kingsley et al .…”

Section: Spheroid Generation Methodsmentioning

confidence: 99%

Using Spheroids as Building Blocks Towards 3D Bioprinting of Tumor Microenvironment

Zhuang¹,

Chiang²,

Fernanda³

et al. 2024

IJB

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Cancer still ranks as a leading cause of mortality worldwide. Although considerable efforts have been dedicated to anticancer therapeutics, progress is still slow, partially due to the absence of robust prediction models. Multicellular tumor spheroids, as a major three-dimensional (3D) culture model exhibiting features of avascular tumors, gained great popularity in pathophysiological studies and high throughput drug screening. However, limited control over cellular and structural organization is still the key challenge in achieving in vivo like tissue microenvironment. 3D bioprinting has made great strides toward tissue/organ mimicry, due to its outstanding spatial control through combining both cells and materials, scalability, and reproducibility. Prospectively, harnessing the power from both 3D bioprinting and multicellular spheroids would likely generate more faithful tumor models and advance our understanding on the mechanism of tumor progression. In this review, the emerging concept on using spheroids as a building block in 3D bioprinting for tumor modeling is illustrated. We begin by describing the context of the tumor microenvironment, followed by an introduction of various methodologies for tumor spheroid formation, with their specific merits and drawbacks. Thereafter, we present an overview of existing 3D printed tumor models using spheroids as a focus. We provide a compilation of the contemporary literature sources and summarize the overall advancements in technology and possibilities of using spheroids as building blocks in 3D printed tissue modeling, with a particular emphasis on tumor models. Future outlooks about the wonderous advancements of integrated 3D spheroidal printing conclude this review.

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“…However, extrusion-based printing generally dispenses the cell-laden inks as fibers with a relatively low resolution of ~100 µm, which makes the method unsuitable for single-cell printing [47]. Contrarily, laser-based cell printing has long been utilized in single-cell printing because laser printing can precisely select and position live cells on a predefined location from a cell suspension with high density [71][72][73][74][75]. In laser-based cell printing, cells are pre-loaded on a laser-sensitive surface, and then the laser is applied to transfer the target cells onto an underlying substrate [47].…”

Section: Noncontact Printingmentioning

confidence: 99%

Advances in Single-Cell Printing

Zhou¹,

Wu²,

Wen³

et al. 2022

Micromachines

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Single-cell analysis is becoming an indispensable tool in modern biological and medical research. Single-cell isolation is the key step for single-cell analysis. Single-cell printing shows several distinct advantages among the single-cell isolation techniques, such as precise deposition, high encapsulation efficiency, and easy recovery. Therefore, recent developments in single-cell printing have attracted extensive attention. We review herein the recently developed bioprinting strategies with single-cell resolution, with a special focus on inkjet-like single-cell printing. First, we discuss the common cell printing strategies and introduce several typical and advanced printing strategies. Then, we introduce several typical applications based on single-cell printing, from single-cell array screening and mass spectrometry-based single-cell analysis to three-dimensional tissue formation. In the last part, we discuss the pros and cons of the single-cell strategies and provide a brief outlook for single-cell printing.

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Laser‐Based Printing: From Liquids to Microstructures

Cited by 29 publications

References 183 publications

Wavelength‐Scale Photonic Space Switch Proof‐Of‐Concept Based on Photonic Hook Effect

Wavelength‐Scale Photonic Space Switch Proof‐Of‐Concept Based on Photonic Hook Effect

Using Spheroids as Building Blocks Towards 3D Bioprinting of Tumor Microenvironment

Advances in Single-Cell Printing

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