Laser-based mid-infrared reflectance imaging of biological tissues

Guo, Bujin; Wang, Y.; Peng, Chuan; Zhang, H. L.; Luo, Guoping; Le, H. Q.; Gmachl, Claire F.; Sivco, D. L.; Peabody, Milton L.; Cho, A.Y.

doi:10.1364/opex.12.000208

Cited by 120 publications

(72 citation statements)

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“…Comment: Detection limit ~ 120µm [7,12] 4.34µm CO2 Standard deviation 11.3mg/l, detection limit 33.9mg/l 580µm [13] 5.4µm An absorption coefficient of 0.023/µm is measured From the maximum absorption pathlength of 580µm demonstrated at 5.4µm [13], we believe it is reasonable to have a similar path length at 4.34µm (2,340cm -1 ) where the absorption is calibrated to be ~ 0.024/µm. In reference [13] where work was done before 2004 and 580µm of pathlength is demonstrated, they used a weak laser with peak power less than 2mW and duty cycle of 1.5%, or average power only 30µW.…”

Section: Optical Pathlength Wavelengthmentioning

confidence: 99%

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Subsurface Monitor for Dissolved Inorganic Carbon at Geological Sequestration Site Phase 1 SBIR Final Report

Sheng¹

2012

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Section: Optical Pathlength Wavelengthmentioning

confidence: 99%

“…In reference [13] where work was done before 2004 and 580µm of pathlength is demonstrated, they used a weak laser with peak power less than 2mW and duty cycle of 1.5%, or average power only 30µW.…”

Section: Optical Pathlength Wavelengthmentioning

confidence: 99%

Subsurface Monitor for Dissolved Inorganic Carbon at Geological Sequestration Site Phase 1 SBIR Final Report

Sheng¹

2012

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“…Supercontinuum sources based on silica photonic crystal fibers (PCF), operating in spectral range from the visible to the near-infrared, have been already commercialized. Interest is now focused on supercontinua covering near-infrared/mid-infrared part of spectrum, where vibration bands of a number of important organic compounds are located (Waynant et al 2001;Werle et al 2002;Guo et al 2004). Effective supercontinuum generation at wavelengths longer than 2,000 nm requires optical fibers with transmission in the mid-infrared.…”

Section: Introductionmentioning

confidence: 99%

Mid-infrared supercontinuum generation in soft-glass suspended core photonic crystal fiber

et al. 2013

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Supercontinuum from 800 to 2,600 nm has been obtained in a soft glass suspendedcore photonic crystal fiber. The fiber has been fabricated using an in-house synthesized, lead-bismuth-galate oxide glass (PBG-08), which has a transmission window from 500 nm to 4,500 nm. Dispersion characteristic has been designed to enable efficient pumping in the anomalous regime, using typical telecommunication wavelengths and influence of discrepancy between design and physical dispersion profile of fiber is discussed. An optical parametric amplifier system seeded with a Ti:Sapphire oscillator has been used as a light source (70 fs pulses with 100 kHz repetition rate). Supercontinuum bandwidth on the midinfrared side is limited by OH − absorption of the glass and presence of second zero-dispersion wavelength in the spectral area of interest. Flatness the spectrum remains under 7 dB from roughly 1,800 nm to about 2,500 nm.

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“…Driven by intense carrier-envelope phase-stable MIR pulses, high-order harmonic generation process exhibits higher cut-off energy, supporting shorter isolated attosecond pulses [2]. Broadband MIR light sources are also essential in optical coherence tomography [3,4], since broad spectrum leads to ultrahigh resolution and longer wavelength results in better penetration depth. As MIR light sources have widespread applications, several approaches are made to obtain laser radiations at this wavelength region.…”

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confidence: 99%

Generation of broadband 17-μJ mid-infrared femtosecond pulses at 375 μm by silicon carbide crystal

Fan¹,

Xu²,

Wang³

et al. 2014

Opt. Lett.

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In this contribution, we report the generation of 17-μJ mid-infrared (MIR) pulses with duration of 70 fs and bandwidth of 550 nm centered at 3.75 μm at 1-kHz repetition rate, by a two-stage femtosecond optical parametric amplifier utilizing 4H-silicon carbide crystal as the nonlinear medium. The crystal is selected as it processes orders of magnitude higher damage threshold than traditional MIR nonlinear crystals, and it supports extreme broad parametric bandwidth. With its distinguished features such as MIR central wavelength, ultra-broad bandwidth, self-stable carrier-envelope phase, and potential for energy scaling, this kind of MIR source holds promise for new approaches to extreme short isolated attosecond pulse generation as well as MIR spectroscopy applications. Mid-infrared (MIR) light sources in the molecular "fingerprint" region are of paticular importance in a number of disciplines, including industrial process monitoring, environmental monitoring, and molecular identification [1]. Driven by intense carrier-envelope phase-stable MIR pulses, high-order harmonic generation process exhibits higher cut-off energy, supporting shorter isolated attosecond pulses [2]. Broadband MIR light sources are also essential in optical coherence tomography [3,4], since broad spectrum leads to ultrahigh resolution and longer wavelength results in better penetration depth. As MIR light sources have widespread applications, several approaches are made to obtain laser radiations at this wavelength region. Lead-salt diodes exhibit two orders of magnitude lower Auger recombination rate compared with other materials, but they are hindered in applications by a low working temperature requirement, especially for continuous wave operation [5,6]. Unlike lead-salt lasers, the main nonradiative channel for quantum cascade lasers [7,8] is optical phonon emission rather than the Auger effect. That offers opportunities for room temperature operation. However, quantum cascade lasers suffer from their low wall plug efficiency, which sets limitation to applications such as portable sensors and infrared counter measurements [9]. Additionally, generation of lasers with wavelength longer than 3 μm based on solid-state lasers is limited by the multiphonon relaxation process in gain media at room temperature [10].Different from the laser radiation obtained by stimulated emission process mentioned above, nonlinear frequency conversion techniques as the third-generation femtosecond technology [11] have been developed to acquire MIR pulses. By utilizing virtual energy levels for amplification, they are free of cooling systems as no energy accumulates inside the gain media. Among these techniques, optical parametric amplification (OPA) [12][13][14][15][16][17][18], owing to its distinguished advantages including ultra-broad parametric bandwidth and ultrahigh gain per pass, has become an ideal way to generate MIR pulses, compared with other nonlinear processes [19][20][21][22][23][24][25].A series of nonlinear crystals are employed to serve in thes...

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Laser-based mid-infrared reflectance imaging of biological tissues

Cited by 120 publications

References 0 publications

Subsurface Monitor for Dissolved Inorganic Carbon at Geological Sequestration Site Phase 1 SBIR Final Report

Subsurface Monitor for Dissolved Inorganic Carbon at Geological Sequestration Site Phase 1 SBIR Final Report

Mid-infrared supercontinuum generation in soft-glass suspended core photonic crystal fiber

Generation of broadband 17-μJ mid-infrared femtosecond pulses at 375 μm by silicon carbide crystal

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