Laser assisted synthesis of inorganic fullerene like MoS2-Au nanohybrid and their cytotoxicity against human monocytic (THP-1) cells

Panchu, Sarojini Jeeva; Dhani, Shanel; Chuturgoon, Anil A.; Moodley, Mathew

doi:10.1016/j.jphotobiol.2018.07.028

Cited by 11 publications

(5 citation statements)

References 33 publications

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“…Moreover, due to their being good lubricants, the addition of IF/INT to polymer blends does not lead to large increase in the viscosity, or sometime incur reduced viscosity, which has substantial implications for the processing and production costs of the polymer nanocomposites in industrial environment. Nanoparticles of MX 2 materials, including IF/INT were found to be relatively nontoxic and benign up to high concentrations (>0.1 mg/ml), [181][182][183] offering them potential applications in different medical technologies. Another important area of research is in shock absorbance, which is relevant to many applications including the automotive industry, sport, prostheses, self-protecting jackets and many more.…”

Section: Conclusion and Applications -Future Prospectsmentioning

confidence: 99%

An overview of the recent advances in inorganic nanotubes

2019

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Section: Conclusion and Applications -Future Prospectsmentioning

confidence: 99%

An overview of the recent advances in inorganic nanotubes

2019

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“…The EE and LE of the nanospheres were determined (Yang et al, 2017). The nanospheres were characterized using FTIR (Abbas et al, 2018;Dong et al, 2018), electron microscopy (Shi et al, 2016;Nantachit et al, 2017;Tao et al, 2018), and laser particle size analysis (Couvreur et al, 2002;Zhang et al, 2015;Shi et al, 2016;Ahmad et al, 2018;Panchu et al, 2018;von Halling Laier et al, 2018). The results showed that C-PC/CMC-CD55sp nanospheres were successfully constructed.…”

Section: Discussionmentioning

confidence: 99%

“…Nanospheres morphology was observed using a transmission electron microscope (Shi et al, 2016;Nantachit et al, 2017;Tao et al, 2018). Zeta potential (surface charge) and particle size (nanospheres size) were measured using a laser particle size analyzer at 25°C (Zhang et al, 2015;Ahmad et al, 2018;Panchu et al, 2018;von Halling Laier et al, 2018).…”

Section: Synthesis Of C-pc/cmc-cd55sp Nanospheresmentioning

confidence: 99%

Targeted Antitumor Mechanism of C-PC/CMC-CD55sp Nanospheres in HeLa Cervical Cancer Cells

Liu

Jiang

et al. 2020

Front. Pharmacol.

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In vitro studies had shown that C-Phycocyanin (C-PC) inhibited cervical cancer HeLa cells growth. We constructed C-PC/CMC-CD55sp nanospheres using C-PC, Carboxymethyl Chitosan (CMC), and CD55 ligand peptide (CD55sp) to allow for targeted antitumor effects against HeLa cells in vitro and in vivo. The characteristics of the nanospheres were determined using FTIR, electron microscopy, and laser particle size analysis. Flow cytometry, laser confocal microscopy and small animal imaging system showed the targeting of C-PC/CMC-CD55sp nanospheres on HeLa cells. Subsequently, the proliferation and apoptosis were analyzed by Cell Counting Kit-8 (CCK-8), flow cytometry, TUNEL assay and electron microscopy. The expression of the apoptosisrelated protein was determined using western blot. The stainings of Hematoxylin and Eosin (HE) were employed to evaluate the cell condition of tumor tissue sections. The cytokines in the blood in tumor-bearing nude mice was determined using ELISA. These results showed that C-PC/CMC-CD55sp nanospheres were successfully constructed and targeted HeLa cells. The constructed nanospheres were more effective than C-PC alone in inhibiting the proliferation and inducing apoptosis in HeLa cells. We also found that C-PC/CMC-CD55sp nanospheres had a significant inhibitory effect on the expression of antiapoptotic protein Bcl-2 and a promotion on the transformation of caspase 3 to cleaved caspase 3. C-PC/CMC-CD55sp nanospheres played an important role in tumor suppression, reduced the expression TGF-b, and increased IL-6 and TNF-a. This study demonstrates that the constructed new C-PC/CMC-CD55sp nanospheres exerted targeted antitumor effects in vivo and in vitro which provided a novel idea for application of C-PC, and provided experimental basis for comprehensive targeted treatment of tumors.

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“…The opportunities of developing MoS 2 -based van der Waal heterostructures with other 2D materials, such as graphene, h -BN, phosphorene, MoSe 2 , MoTe 2 , WS 2 , WSe 2 , WTe 2 , HfS 2 , ZrS 2 , FeS 2 , FeSe 2 , TiS 2 , TaS 2 , TaSe 2 , PtTe 2 , NiSe 2 , NbSe 2 , CoS 2 , CoSe 2 , SnSe, SnS 2 , GaTe, Janus TMDs, inorganic and organic materials, and vice versa, are enormous, and represent the future direction of atomically thin layered TMDs. The daily surge in research activities on 2D TMDs is unprecedented, as researchers seek their new applications in CMOS, sensors, − catalysis, − energy devices, − solar cells , miRNA detection, lasers, light-emission, , and cancer imaging and therapy. − For practical applications, it is also equally important to examine the long-term environmental and mechanical stability of the electronic devices, as well as the cytotoxicity of atomic-layered TMDs toward human. − TMDs are emerging as the future generation of multifunctional and wearable nanomaterials, as an alternative to the currently available costly semiconductors used in the electronic and optoelectronic industries. Flexible atomically thin layered TMDs offer tremendous new opportunities for applications in many different research fields.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Flexible Molybdenum Disulfide (MoS₂) Atomic Layers for Wearable Electronics and Optoelectronics

Singh

Kim

et al. 2019

ACS Appl. Mater. Interfaces

296

213

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Flexible, stretchable, and bendable materials, including inorganic semiconductors, organic polymers, graphene, and transition metal dichalcogenides (TMDs), are attracting great attention in such areas as wearable electronics, biomedical technologies, foldable displays, and wearable point-of-care biosensors for healthcare. Among a broad range of layered TMDs, atomically thin layered molybdenum disulfide (MoS 2 ) has been of particular interest, due to its exceptional electronic properties, including tunable bandgap and charge carrier mobility. MoS 2 atomic layers can be used as a channel or a gate dielectric for fabricating atomically thin field-effect transistors (FETs) for electronic and optoelectronic devices. This review briefly introduces the processing and spectroscopic characterization of large-area MoS 2 atomically thin layers. The review summarizes the different strategies in enhancing the charge carrier mobility and switching speed of MoS 2 FETs by integrating high-κ dielectrics, encapsulating layers, and other 2D van der Waals layered materials into flexible MoS 2 device structures. The photoluminescence (PL) of MoS 2 atomic layers has, after chemical treatment, been dramatically improved to near-unity quantum yield. Ultraflexible and wearable active-matrix organic light-emitting diode (AM-OLED) displays and wafer-scale flexible resistive random-access memory (RRAM) arrays have been assembled using flexible MoS 2 transistors. The review discusses the overall recent progress made in developing MoS 2 based flexible FETs, OLED displays, nonvolatile memory (NVM) devices, piezoelectric nanogenerators (PNGs), and sensors for wearable electronic and optoelectronic devices. Finally, it outlines the perspectives and tremendous opportunities offered by a large family of atomically thin-layered TMDs. KEYWORDS: molybdenum disulfide (MoS 2 ), flexible electronics, flexible field-effect transistors (FETs), wearable organic light-emitting diode (OLED), flexible memory devices, flexible piezoelectric nanogenerators (PNGs), sensors

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Laser assisted synthesis of inorganic fullerene like MoS2-Au nanohybrid and their cytotoxicity against human monocytic (THP-1) cells

Cited by 11 publications

References 33 publications

An overview of the recent advances in inorganic nanotubes

An overview of the recent advances in inorganic nanotubes

Targeted Antitumor Mechanism of C-PC/CMC-CD55sp Nanospheres in HeLa Cervical Cancer Cells

Flexible Molybdenum Disulfide (MoS₂) Atomic Layers for Wearable Electronics and Optoelectronics

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Laser assisted synthesis of inorganic fullerene like MoS2-Au nanohybrid and their cytotoxicity against human monocytic (THP-1) cells

Cited by 11 publications

References 33 publications

An overview of the recent advances in inorganic nanotubes

An overview of the recent advances in inorganic nanotubes

Targeted Antitumor Mechanism of C-PC/CMC-CD55sp Nanospheres in HeLa Cervical Cancer Cells

Flexible Molybdenum Disulfide (MoS2) Atomic Layers for Wearable Electronics and Optoelectronics

Contact Info

Product

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Flexible Molybdenum Disulfide (MoS₂) Atomic Layers for Wearable Electronics and Optoelectronics