Laser and Platelet-Rich Plasma to treat Medication-Related Osteonecrosis of the Jaws (MRONJ): a case report

Fornaini, Carlo; Cella, Luigi; Oppici, Aldo; Parlatore, Anna; Clini, Fabio; Fontana, Matteo; Lagori, Giuseppe; Merigo, Elisabetta

doi:10.5978/islsm.17-cr-04

Cited by 18 publications

(10 citation statements)

References 13 publications

(11 reference statements)

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“…Indeed, PRP accelerates epithelial wound healing, decreases tissue inflammation, improves the regeneration of bone and soft tissues, and promotes tissue vascularization. Considering these benefits, PRP would be effective in BRONJ patients in the way that releases growth factors and stimulates the bone healing and neoangiogenesis, which is usually suppressed by BPs [ 26 , 31 – 37 ]. Moreover, PRP as an autologous product possesses biocompatibility and safety.…”

Section: Introductionmentioning

confidence: 99%

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Mauceri

Panzarella

Maniscalco

et al. 2018

BioMed Research International

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Introduction The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. Methods We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer. Results We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patients underwent a surgical laser-assisted therapy together with autologous PRP. At the latest follow-up at 12 months, clinical improvement was observed in eight patients. Registration Number is IRCT20180329039159N1. Conclusion We could successfully manage the BRONJ utilizing this combined protocol to heal the 30% of surgically treated sites and to improve the 50% of patients' lesions clinically. Our findings suggest that a surgical approach combined with Er,Cr:YSGG laser and PRP benefit cancer patients with general health issues.

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Section: Introductionmentioning

confidence: 99%

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Mauceri

Panzarella

Maniscalco

et al. 2018

BioMed Research International

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“…In oral medicine and maxillofacial surgery, PRP use has been described, for example, for the treatment of bone diseases such as medication-related osteonecrosis of the jaws (MRONJ), particularly in addition to surgical protocol as a gel for topic application [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Platelet-Rich Plasma (PRP) Rinses for the Treatment of Non-Responding Oral Lichen Planus: A Case Report

et al. 2018

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Platelet-rich plasma (PRP) has been proposed for different applications in the medical field and in maxillofacial surgery thanks to its many growth factors, such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and keratinocyte growth factor (KGF). Oral lichen planus (OLP) is a disease that affects the oral mucosa in a chronic way. This disease frequently worsens the quality of life of patients, particularly when clinical manifestations are of the erythematous or erosive/ulcerative type. The properties of PRP that are supported by scientific literature in both oral medicine and other medical fields have suggested the introduction of PRP in clinical practice for the medical treatment of different soft tissues diseases, such as when OLP patients do not respond to conventional therapies, or when conventional treatments have some contraindications or side effects. The aim of this work is to describe the use of PRP used as an oral rinse for the treatment of a patient diagnosed as affected by OLP at the Dentistry, Special Needs and Maxillo-Facial Surgery Unit of the Hospital of Piacenza. PRP protocol was started after the failure of conventional therapies based on the use of topical and systemic corticosteroids, hydroxychloroquine, and low-level laser therapy applications.

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“…Algumas pesquisas foram fundamentais para a formulação de novos conceitos na utilização da TLBI, as quais comprovaram a eficácia da TLBI na sessão única intraoral (Kahraman, Cetiner & Strauss, 2017); diminuição do edema e da dor pós-operatória (De Carli et al, 2016;Ezzat et al, 2016;Tuk et al, 2017;D'Ávila et al, 2019;Santos et al, 2019;Singh et al, 2019); eficácia na combinação de cirurgia, antibioticoterapia e TLBI (Momesso et al, 2017;Rodríguez-Sánchez et al, 2020); melhora neurossensorial (Eshghpour et al, 2017;Mohajerani et al, 2017;Santos et al, 2018); redução da incidência e gravidade de morbidade no pós-operatório (Fornaini et al, 2017) e recuperação de parestesia (Evangelista et al, 2019;Haghighat et al, 2020). Theodoro et al (2018) concluíram em sua pesquisa que a TLBI não favorece o aumento da formação óssea, em vez disso, acelera o processo de remodelação óssea.…”

Section: Resultsunclassified

Estudo da eficácia do laser de baixa intensidade em cirurgia bucomaxilofacial: Uma revisão narrativa da literatura

Silveira

Veríssimo

Inaoka

et al. 2021

RSD

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Objetivo: Este trabalho tem como objetivo analisar artigos científicos já feitos para que se possa ter maior aquiescência das informações obtidas, a fim de desenvolver um trabalho atualizado sobre a eficácia do laser de baixa intensidade em cirurgia bucomaxilofacial. Metodologia: Esta revisão narrativa da literatura possui uma metodologia qualitativa no desenvolvimento da seguinte pergunta de pesquisa: O laser de baixa intensidade tem eficácia em cirurgia bucomaxilofacial? Sendo assim, fez-se uso da base de dados eletrônica U. S. National Library of Medicine (PubMed (NLM)), com seleção dos seguintes MeSHterms: “Laser therapy”; “Oral surgery”. Os critérios de inclusão foram os seguintes: artigos publicados na íntegra gratuitamente; artigos publicados em inglês, português e espanhol; publicações entre janeiro de 2016 e maio de 2021 e artigos que se adequem à temática. Resultados: A partir dessa estratégia de busca, foram encontrados 3.015 trabalhos na íntegra; destes, 6 artigos encontravam-se duplicado nas estratégias de busca, totalizando, assim, 27 trabalhos selecionados após aplicação dos critérios de inclusão e exclusão. Considerações finais: O laser de baixa intensidade pode ser utilizado em cirurgia bucomaxilofacial por apresentar mecanismos biológicos favoráveis à recuperação no pós-operatório, auxiliando na redução do edema e sintomatologia dolorosa.

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Laser and Platelet-Rich Plasma to treat Medication-Related Osteonecrosis of the Jaws (MRONJ): a case report

Abstract: This case may suggest that this kind of combined approach during all the steps of MRONJ treatment allows to perform a faster and less invasive surgery with a more comfortable postoperative healing process and it represents an innovative approach in this severe adverse event.

Cited by 18 publications

References 13 publications

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Platelet-Rich Plasma (PRP) Rinses for the Treatment of Non-Responding Oral Lichen Planus: A Case Report

Estudo da eficácia do laser de baixa intensidade em cirurgia bucomaxilofacial: Uma revisão narrativa da literatura

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