Laser and photodynamic therapy in the management of cutaneous malignancies

Zeitouni, Nathalie C.; Shieh, Sherry; Oseroff, Allan R.

doi:10.1016/s0738-081x(01)00170-5

Cited by 69 publications

(52 citation statements)

References 119 publications

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“…Essa abordagem terapêutica está se tornando uma opção no tratamento de doenças, incluindo lesões tumorais e pré-tumorais, desordens vasculares proliferativas e foi recentemente aprovada pelo "Food and Drug Administration" dos Estados Unidos e na Europa para queratose actínica e carcinomas de células basais 51 .…”

Section: áCido 5-aminolevulínicounclassified

Inativação fotodinâmica de microrganismos

Perussi¹

2007

Quím. Nova

112

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Section: áCido 5-aminolevulínicounclassified

Inativação fotodinâmica de microrganismos

Perussi¹

2007

Quím. Nova

112

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“…70,71 Photodynamic therapy, which is laser treatment after the application of a photosensitizing drug such as 5-aminolevulinic acid, is a treatment for actinic keratoses and an investigational therapy for KC. 72 After treatment, patients with KC should receive regular follow-up examinations. SCC recurrence or metastasis usually occurs within the first 3 years, so they should be followed particularly carefully during this time.…”

Section: Treatmentmentioning

confidence: 99%

Keratinocyte Carcinoma

Albert

Weinstock

2003

CA: A Cancer Journal for Clinicians

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Keratinocyte carcinoma is by far the most common cancer in the United States.Basal cell carcinomas and squamous cell carcinomas account for approximately 80% and 20% of cases of KC, respectively. The term nonmelanoma skin cancer is commonly used to refer to squamous cell carcinomas and basal cell carcinomas; however, other types of nonmelanoma skin cancer, such as adnexal tumors and sarcomas, are less common and differ in their cell type, behavior, and epidemiologic features from KC.1 Primary care clinicians are well positioned to diagnose KC and to educate patients about preventive measures such as sun protection and self-examination. Here we review epidemiologic data and strategies for prevention, diagnosis, and clinical management of KC. (CA Cancer J Clin 2003;53:292-302.)

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“…PDT involves in situ photo-activation of photosensitizers (PSs) by light at appropriate wavelength, generating highly active and short-lived oxygen derived species [8]. These cytotoxic species, including singlet oxygen and free radicals, induce direct oxidative damage to cellular organelles, destruction of microvasculature, and promotion of apoptosis [9]. PDT may also impart an immunological effect as well as a local apoptotic effect [10].…”

Section: Introductionmentioning

confidence: 99%

Methylene blue‐mediated photodynamic therapy: A possible alternative treatment for oral lichen planus

et al. 2006

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Background and Objectives: In this study, methylene blue-mediated photodynamic therapy (MB-PDT) was used as a possible alternative method for the treatment of oral lichen planus (OLP). Study Design/Materials and Methods: Thirteen patients with 26 OLP lesions were enrolled in this study. Patients were instructed to gargle a 5% methylene blue solution in water for 5 minutes. Ten minutes later, irradiation was performed by laser light (l ¼ 632 nm, light exposure dose ¼ 120 J/cm 2 ). Lesions were evaluated pre and post-operatively and at follow-up sessions by changes in sign and symptom (pain) scores, and size of lesions. Results: Improvement in sign scores was achieved in 16 lesions. Four keratotic lesions disappeared completely. There was a statistically significant decrease in sign and symptom scores 1 week after treatment and at follow-up sessions up to 12 weeks. Average reduction in size of lesions was 44.3%. Conclusion: MB-PDT seems to be an effective alternative treatment for control of OLP. In our opinion, this preliminary result warrant further studies in order to show the efficacy of MB-PDT in control of OLP for a longer period of time.

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Laser and photodynamic therapy in the management of cutaneous malignancies

Cited by 69 publications

References 119 publications

Inativação fotodinâmica de microrganismos

Inativação fotodinâmica de microrganismos

Keratinocyte Carcinoma

Methylene blue‐mediated photodynamic therapy: A possible alternative treatment for oral lichen planus

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