Laser and light therapy for onychomycosis: a systematic review

Ledon, Jennifer; Savas, Jessica; França, Katlein; Chacon, Anna; Nouri, Keyvan

doi:10.1007/s10103-012-1232-y

Cited by 50 publications

(31 citation statements)

References 35 publications

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“…Studies have shown that the healing influences of photomedicine are due to transformation of absorbed energy into ATP. 33,34 In this study, we compared and evaluated the biological effects of low-power laser light with LED light. The main important difference between low power lasers and LED light is the coherence parameter.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of 660 nm Low-Level Laser and Light Emitted Diode in Proliferative Effects of Fibroblast Cells

et al. 2017

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Introduction: In recent years, low-power lasers have been widely used in medicine. With the introduction of affordable light emitted diode (LED), clinical application of LED light has become more and more popular. However, some researchers believe that due to lack of coherence of the LED light, it can be different in terms of biological effects, in comparison with laser. In this study, the biological effects of low-level laser (LLL) to those of LED light are compared and discussed. Methods: Human skin fibroblast cell line Hu02 was irradiated with LLL and LED light with a wavelength of 660 nm, power output of 35 mW and in continuous mode and the control group was not irradiated. The biological effects were compared through analysis of cell proliferation, production of reactive oxygen species (ROS) within the cell and rate of cell division. Results: Our findings showed that production of ROS within the cell was linearly increased both in the LED and laser light irradiated cells. However, laser light is more incremental in comparison to LED light. The MTT results showed that laser light at low energy density (less than 5 J/cm 2 ) increased the rate of cell proliferation after 24 hours. Although, the rate of cell division was increased in energy density of 1 J/cm 2 compared to the control group, this increase was not statistically significant. Discussion: The findings indicated that the coherence properties of laser light provided more energy for the cells, and in a constant energy density, laser light created more oxidative stresses in comparison with LED light.

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Section: Discussionmentioning

confidence: 99%

A Comparative Study of 660 nm Low-Level Laser and Light Emitted Diode in Proliferative Effects of Fibroblast Cells

et al. 2017

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“…Puede ser debido a la presencia de sesgos tales como la selección de tamaños muestrales demasiado pequeños, sobre todo si se tienen en cuenta los datos de epidemiología de la onicomicosis o el empleo de diferente tipo de tecnología láser o bien con longitudes de onda diferentes, tal como se deduce de lo ampliamente publicado en diferentes estudios (4,8,27). Dicha variabilidad en cuanto a tratamientos y resultados se debe al empleo tanto de láser de alta potencia con luz pulsada y neodimio, a láser de co2 así como láser de diodo o terapia fotodinámica o de ultravioleta, que también han sido empleados para el tratamiento de la onicomicosis (4,6,7).…”

Section: Discussionunclassified

“…En función de su longitud de onda y su tecnología los láser tienen diferentes aplicaciones y resultados para el tratamiento de onicomicosis (2,4,25) lo que complica la existencia de una pauta homogénea de aplicación y, por tanto, la posibilidad de validación científica de tratamiento protocolizado para onicomicosis. En este sentido, habría que tener en cuenta en este sentido las diferencias entre los láser de luz pulsada, como el de 1.064 nanómetros (nm) de longitud de onda de neodimio, o el de 980 nm de diodo (2,4); ya que los dos, el neodimio y diodo, son los más más extendidos para el tratamiento de onicomicosis.…”

Section: Introductionunclassified

Evidencia Científica De La Laserterapia En Onicomicosis

Navarro‐Flores

2017

Eur J Pod

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Objective: In recent years it has expanded laser treatment as an adjunct treatment of onychomycosis. There are different publications, relating to different types of laser for the treatment of onychomycosis, contain various efficacy results. This paper lists the results obtained in different studies to determine the efficacy of this therapy. To determine the efficacy of laser therapy in cases of nail fungal infections. Set the level of scientific evidence of laser treatment in fungal nail infections. Methods: A revision work is done by literature search biomedical databases PubMed, Scopus, Embase and Web de Science® (WOS) using the keywords "laser, nail, mycosis and treatment". 50 results. those studies employing laser treatment of onychomycosis were included. Published during the last 5 years excluding those who did not meet that requirement. Results: Initially 390 results related to laser treatment of onychomycosis of the feet are obtained; both neodymium and CO2 laser diode. In the last five years, only 121 results were obtained. Finally they chose 50 studies, of which 20 were clinical trials, 16 experimental studies and 14 reviews with results proven in vitro and application guidelines varied effectiveness of disparate treatment. Conclusions: more clinical trials is needed, with a larger population of study to determine appropriate manner from the point of view of scientific evidence if there is a correlation between the use of laser and improved symptoms in treatment of onychomycosis, respect of antifungal topical or systemic treatments existing.Key Words: Laser, onychomycosis, nail. ResumenObjetivo: En los últimos años se ha extendido el tratamiento con láser como complemento del tratamiento de la onicomicosis. Existen diferentes publicaciones en relación a los distintos tipos de láser para el tratamiento de las onicomicosis, que contienen diversos resultados de eficacia. El presente trabajo recopila los resultados obtenidos en diferentes estudios con el fin de determinar la eficacia de esta terapia. Determinar la eficacia del tratamiento con laserterapia en casos de infecciones micóticas ungueales. Establecer el nivel de evidencia científica del tratamiento láser en infecciones fúngicas de las uñas. Método: Se realiza un trabajo de revisión mediante búsqueda bibliográfica en las bases de datos biomédicas PubMed, Scopus, Web de Science® (WOS) y Embase empleando las palabras clave "láser, nail, mycosis y treatment". Se obtienen 50 resultados. Se incluyeron aquellos estudios que empleaban el láser para el tratamiento de onicomicosis, publicados durante los últimos 5 años, excluyendo aquellos que no cumplían tal requisito. Resultados: En un principio se obtienen 390 resultados relacionados con el tratamiento con láser de onicomicosis de los pies; tanto para láser CO 2 neodimio como de diodo. De los últimos cinco años, solamente se obtuvieron 121 resultados. Finalmente se escogieron 50 en estudios, de los cuales 20 eran ensayos clínicos, 16 estudios experimentales, y 14 revisiones con resultados de efi...

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“…The cause of this difference may be related to changes in the vascular flow and elaboration of growth factors that result from heat from the nail apparatus [9,31].…”

Section: Discussionmentioning

confidence: 99%

“…Laser therapy for onychomycosis is a new breakthrough because it has fewer side effects than antifungals. The number of professional lasers approved by the US Food and Drug Administration (FDA) for "temporary clearance" of onychomycosis is continually increasing, most of which are long-pulsed 1,064-nm neodymium:yttrium-aluminum-garnet lasers (LPNYLs) [8,9]. Some researchers believe that laser treatment of onychomycosis is safe and effective [10,11], while others have stated that the use of the Nd:YAG 1,064-nm laser is invalid for treating onychomycosis [12].…”

Section: Patients Includedmentioning

confidence: 99%

The Energy Density and Treatment Times Are the Main Factors That Affect the Efficacy of Long-Pulsed 1,064-nm Nd:YAG Laser Treatment for Onychomycosis Caused by Trichophyton rubrum

Liu¹,

Zhang²,

Zeng³

et al. 2018

Dermatology

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Background: No optimal regimen exists for the LPNYL (long-pulsed 1,064-nm neodymium:yttrium-aluminum-garnet laser) for treating onychomycosis. Objective: To establish an optimal LPNYL treatment regimen for onychomycosis caused by Trichophyton rubrum (OCTr). Patients and Methods: First, 511 infected nails of 177 patients were treated using LPNYL with orthogonally designed regimens according to various energy densities, spot sizes, pulse widths, and treatment times. The optimal treatment regimen was established by multivariate analysis. Next, 69 patients with 221 infected nails were randomized to receive oral itraconazole (drug group) and the optimal regimen of LPNYL treatment (laser group). The clinical efficacy (CE) and mycological efficacy (ME) were evaluated at 6 and 12 months following the start of treatment, and adverse reactions were recorded in both groups. Results: Both CE and ME were significantly correlated with the energy density (p < 0.05) and treatment times (p < 0.05), but not with the spot size (0.071 0.05), and no significant difference was observed in CE at 12 months between the two groups (p > 0.05). At 6 months, the CE in the laser group was significantly higher than that in the drug group (p < 0.001). Conclusions: LPNYL is effective and safe for treating OCTr. The energy density and treatment times are the main factors that affect the efficacy. The optimal regimen for LPNYL is an energy density of 45 J/cm², pulse width of 35 ms, spot size of 4 mm, frequency of 1 Hz, and 6 treatments with 1-week intervals. Laser treatment has rapid clinical recovery.

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Laser and light therapy for onychomycosis: a systematic review

Cited by 50 publications

References 35 publications

A Comparative Study of 660 nm Low-Level Laser and Light Emitted Diode in Proliferative Effects of Fibroblast Cells

A Comparative Study of 660 nm Low-Level Laser and Light Emitted Diode in Proliferative Effects of Fibroblast Cells

Evidencia Científica De La Laserterapia En Onicomicosis

The Energy Density and Treatment Times Are the Main Factors That Affect the Efficacy of Long-Pulsed 1,064-nm Nd:YAG Laser Treatment for Onychomycosis Caused by <b><i>Trichophyton rubrum</i></b>

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