Laser-activated nanoparticles for ultrasound/photoacoustic imaging-guided prostate cancer treatment

Abstract

Prostate cancer (PCa) is the most common malignant tumor in men. Prostate-specific membrane antigen (PSMA), which is overexpressed on the surface of Prostate cancer cells, may serve as a potential therapeutic target. Recently, image-guided and targeted therapy for prostate cancers has attracted much attention by using Prostate-specific membrane antigen targeting nanoparticle. In this study, we produced PSMA-targeted light-responsive nanosystems. These nanosystems of liquid perfluorocarbon cores and polymer shells were loaded with the photosensitizer IR780 and therapeutic drugs paclitaxel. The liquid perfluorocarbon (PFP) in nanoparticles can perform ultrasound-enhanced imaging by liquid-gas transition and promote the deliver and release of paclitaxel. IR780 can perform photothermal therapy (PTT) guided by photoacoustic (PA) imaging. Combination treatment with photothermal therapy and chemotherapy exhibited excellent inhibition of cell proliferation in vitro and a significant therapeutic effect in vivo. In conclusion, we successfully formulated PSMA-targeted nanosystems with precision targeting and ultrasound/PA dual-modality imaging for anti-tumor effects.

Photothermal therapy: a novel potential treatment for prostate cancer

“…It has a good inhibitory effect on cell proliferation and has a remarkable therapeutic effect in vivo. 204 Some other targets of prostate cancer include GnRHR and NCL. For example, Wang Singh and colleagues synthesized a functional AuNCs-LHRHa nanosystem for dual-mode (FL/CT) image-guided PTT through the 808 nm NIR targeted prostate cancer treatment platform where AuNCs and LHRHa are connected through amidation reactions.…”

Unleashing novel horizons in advanced prostate cancer treatment: investigating the potential of prostate specific membrane antigen-targeted nanomedicine-based combination therapy

“…In a recent study by Xiao et al. ( 191 ), FDA-approved poly-lactic-glycolic changeable liquid PFP, photosensitizer IR780, and therapeutic drugs Paclitaxel, to perform PTT combined chemotherapy on PSMA + C4-2 PCa tissues. By modifying the surface of nanocarriers with anti-PSMA antibodies, this P-PIP nanoparticle achieved more precise cell targeting.…”