Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Powerful Tool for Spatially Resolved Analysis: An Experiment for Undergraduate Analytical Chemistry Laboratory
Abstract:A new experiment using laser ablation with inductively
coupled
plasma mass spectrometry (LA-ICP-MS) was designed for chemistry undergraduate
students. While most analytical methods only provide information on
the amount of the analyte, LA-ICP-MS allows extra information on the
distribution of the element in the sample. Because it achieves excellent
limits of detection (sub μg·g–1) and
high spatial resolution (micrometer scale), it is a powerful technique
for imaging any sample. A thin section of mouse tissue w… Show more
“…The technique has widespread applications in environmental, , forensic, industrial, and health measurements; , hence, its fundamentals and applications are featured in many analytical chemistry courses. There are a few examples of ICP-MS experiments aimed at undergraduates. − However, opportunities for undergraduates to gain practical experience of ICP-MS are not widespread, owing to the high purchase and running cost of the instrumentation along with the large footprint of some types of ICP-MS and their associated services. In 2018, a simulation was developed to provide students with experience with tuning an ICP-MS instrument .…”
An ICP-MS simulation was developed to support the teaching of inductively coupled plasma−mass spectrometry. The app enables students to conduct the quantification of selenium in a nutritional supplement, monitor the uptake of metallodrugs by cells, and perform qualitative analysis of gunshot residue. The experiments teach a range of analytical concepts, including awareness of mass resolution, selection of method parameters, use of internal standards, and statistical evaluation of data. The app is available as freeware for Windows computers, and it is compatible with a tuning application to enable the generation of unique data sets for every user. The software has been successfully used by groups of undergraduate and postgraduate students to support learning in mass spectrometry lecture courses.
“…The technique has widespread applications in environmental, , forensic, industrial, and health measurements; , hence, its fundamentals and applications are featured in many analytical chemistry courses. There are a few examples of ICP-MS experiments aimed at undergraduates. − However, opportunities for undergraduates to gain practical experience of ICP-MS are not widespread, owing to the high purchase and running cost of the instrumentation along with the large footprint of some types of ICP-MS and their associated services. In 2018, a simulation was developed to provide students with experience with tuning an ICP-MS instrument .…”
An ICP-MS simulation was developed to support the teaching of inductively coupled plasma−mass spectrometry. The app enables students to conduct the quantification of selenium in a nutritional supplement, monitor the uptake of metallodrugs by cells, and perform qualitative analysis of gunshot residue. The experiments teach a range of analytical concepts, including awareness of mass resolution, selection of method parameters, use of internal standards, and statistical evaluation of data. The app is available as freeware for Windows computers, and it is compatible with a tuning application to enable the generation of unique data sets for every user. The software has been successfully used by groups of undergraduate and postgraduate students to support learning in mass spectrometry lecture courses.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.