Laser ablation and ionisation by laser plasma radiation in the atmospheric-pressure mass spectrometry of organic compounds

Pento, A. V.; Никифоров, С. М.; Simanovsky, Ya. O.; Grechnikov, A. A.; Alimpiev, S. S.

doi:10.1070/qe2013v043n01abeh015065

Cited by 19 publications

(7 citation statements)

References 12 publications

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“…30 Recently, an ion source with a laser plasma was proposed to be used to analyze trace amounts of organic compounds in air at atmospheric pressure, in particular, to control biomarkers. [31][32][33] It was shown that the limit of detection for high proton affinity compounds is 1.2 pg with the registration time of 1 s. 34 In our experiments with the laser plasma ion source and various metal targets, it was found that when trace amounts of organic impurities are admixed to the buffer gas, intense ions of metal ion complexes with organic molecules appear in the mass spectra. In the discussion below, we analyze experimental results and the capabilities of such an ion source for the analysis of organic compounds admixtures in the gas phase.…”

Section: Introductionmentioning

confidence: 78%

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Ionization of organic molecules with metal ions formed in the laser plasma

et al. 2021

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A laser plasma ion source was used to ionize volatile organic compounds in a gas sample. The plasma was generated on a metal target in the intermediate vacuum region of ~0.3 Torr using a pulsed Nd:YAG laser with a wavelength of 1 μm. The resulting ions mass spectra were acquired using orthogonal time‐of‐flight mass spectrometer (O‐TOF MS). When using a copper target, the ions formed are simple complexes (CuM+) of copper ions with organic molecules. The possibility of online identification of trace amounts of alkanes in nitrogen and air, with a detection limit of ~10 ppb, was demonstrated. The ionization efficiency of volatile organic compounds through the formation of clusters with metal ions is 10−4 in terms of the quasimolecular complex ions. The rate constants of ion‐molecular reactions of copper ions with octane and water molecules in nitrogen and air are estimated.

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Section: Introductionmentioning

confidence: 78%

“…Recently, an ion source with a laser plasma was proposed to be used to analyze trace amounts of organic compounds in air at atmospheric pressure, in particular, to control biomarkers 31–33 . It was shown that the limit of detection for high proton affinity compounds is 1.2 pg with the registration time of 1 s 34 …”

Section: Introductionmentioning

confidence: 99%

Ionization of organic molecules with metal ions formed in the laser plasma

et al. 2021

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“…To extend the range of identifiable compounds and to enhance the analysis sensitivity, a new method is proposed in [20], with the laser ablation of the sample combined with the ionization of the ablation products by radiation from laser plasma created near the surface of a metal target. This approach came to be known as atmospheric pressure laser plasma ionization (APLPI).…”

Section: Ionization By Laser Plasma Radiation At Atmospheric Pressurementioning

confidence: 99%

“…Figure 5 presents a schematic of the instrumental realization of the APLPI method for the analysis of solid samples [20]. The sample to be studied is mounted on a twoaxis 2 mm pitch stage placed in a hermetic chamber at atmospheric pressure.…”

Section: Ionization By Laser Plasma Radiation At Atmospheric Pressurementioning

confidence: 99%

New approaches to the laser mass spectrometry of organic samples

2015

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“…21 A very similar approach was used by the group around Alimpiev, who employed the LIP plume from a metal target to ionise ambient molecules or clusters introduced into the ionisation chamber by laser ablation or via a microflow controller. 22 More recently they reported on an implementation of this technique into the inlet system of a AP-MS system. 23 However, the plasma is still generated on a metal target.…”

Section: Introductionmentioning

confidence: 99%

Airborne Laser-Spark for Ambient Desorption/Ionisation

Bierstedt

Riedel

2016

Eur J Mass Spectrom (Chichester)

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A novel direct sampling ionisation scheme for ambient mass spectrometry is presented. Desorption and ionisation are achieved by a quasi-continuous laser induced plasma in air. Since there are no solid or liquid electrodes involved the ion source does not suffer from chemical interferences or fatigue originating from erosive burning or from electrode consumption. The overall plasma maintains electro-neutrality, minimising charge effects and accompanying long term drift of the charged particles trajectories. In the airborne plasma approach the ambient air not only serves as the plasma medium but at the same time also slows down the nascent ions via collisional cooling. Ionisation of the analyte molecules does not occur in the plasma itself but is induced by interaction with nascent ionic fragments, electrons and/or far ultraviolet photons in the plasma vicinity. At each individual air-spark an audible shockwave is formed, providing new reactive species, which expands concentrically and, thus, prevents direct contact of the analyte with the hot region inside the plasma itself. As a consequence the interaction volume between plasma and analyte does not exceed the threshold temperature for thermal dissociation or fragmentation. Experimentally this indirect ionisation scheme is demonstrated to be widely unspecific to the chemical nature of the analyte and to hardly result in any fragmentation of the studied molecules. A vast ensemble of different test analytes including polar and non-polar hydrocarbons, sugars, low mass active ingredients of pharmaceuticals as well as natural biomolecules in food samples directly out of their complex matrices could be shown to yield easily accessible yet meaningful spectra. Since the plasma medium is humid air, the chemical reaction mechanism of the ionisation is likely to be similar to other ambient ionisation techniques. Wir stellen hier eine neue Ionisationsmethode für die Umgebungsionisation (ambient ionisation) vor. Sowohl die Desorption als auch die Ionisation erfolgen hierbei durch ein laserbetriebenes Luftplasma. Die Abwesenheit fester oder flüssiger Elektroden hat zur Folge, dass die Methode weder unter chemischen Interferenzen noch unter Verschleiß durch Korrosionsbrand oder abgetragenes Elektrodenmaterial leidet. Insgesamt betrachtet herrscht in dem Plasma Elektroneutralität, wodurch Aufladungseffekte minimiert werden, die andernfalls zu einer langfristigenÄderung der Flugbahnen von Ionen während der Experimente führen kann. In dem Ansatz eine freischwebende Luftentladung bei Atmosphärendruck zu verwenden agiert die Luft nicht nur als Plasmamedium sondert dient zusätzlich als Badgas für die stoßinduzierte Kühlung der entstehenden Ionen. Die Ionisierung der Analytmoleküle erfolgt nicht unmittelbar im Plasma sondern in dessen direkter Umgebung durch Wechselwirkung mit freigesetzten ionischen Luftspezies, freien Elektronen oder Photonen im kurzwelligen ultravioletten Bereich. Jede Laserentladung erzeugt eine hörbare Stoßwelle, in welcher neu produzierte reaktive Spezies freiges...

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Laser ablation and ionisation by laser plasma radiation in the atmospheric-pressure mass spectrometry of organic compounds

Cited by 19 publications

References 12 publications

Ionization of organic molecules with metal ions formed in the laser plasma

Ionization of organic molecules with metal ions formed in the laser plasma

New approaches to the laser mass spectrometry of organic samples

Airborne Laser-Spark for Ambient Desorption/Ionisation

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