The consumption of substances of abuse has become such common practice that we run the risk of trivializing it and no longer considering it a health risk practice. However, reality teaches us that this trivialization is a serious mistake: up to 1.7% of Spanish men aged between 25 and 34 years consume a substance as cardiotoxic and addictive as methamphetamine, 1 and the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) reported that, in 2020, approximately 6000 people would die in Europe from overdoses related to the use of illegal drugs (representing 16.7 deaths/million inhabitants). 2 To understand the reality in greater detail, it is very useful to look carefully at the data offered by those who are closest to the patients who experience adverse reactions to this consumption. 3 Thus, the hospital emergency departments (EDs) of the Euro-DEN plus network have reported that gamma-hydroxybutyric acid (GHB) was present in 11% of visits for acute drug toxicity and in 35% of admissions to intensive care for the same cause and that methamphetamine was identified in 2% of admissions. 2 On the other hand, and from a more local point of view, the Spanish Research Network on Drugs in Hospital Emergency Departments, consisting of the EDs of 11 hospitals in Spain, reported that amphetamines or their derivatives were present in 25.5% of visits for drug use and GHB in 4.7%, 4 and that amphetamines were responsible for 2.3-2.5% of intensive care unit (ICU) admissions. 5,6 Considering specifically people living with HIV, particularly men who have sex with men, the data show us high rates of habitual or recent (in the last year) consumption of drugs. 7 Similarly, the growing popularity of chemsex meetings, in which GHB and methamphetamine are commonly used (along with cocaine, poppers or ketamine), 8 means that EDs are providing increased assistance to patients who are under the influence of multiple substances, the exact type of which is sometimes unknown by both the user and the attending health workers, 9 with the consequent risk of a fatal outcome. 10