Larynx und Hypopharynx

Gale, Nina; Cardesa, Antonio; Zidar, Nina

doi:10.1007/978-3-540-72885-6_7

Cited by 2 publications

(1 citation statement)

References 327 publications

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“…Therefore, for one thyroid nodule, several paths of lymphatic drainage are possible [29][30][31][32]. Furthermore, the primary tumor may reach different regions of the thyroid during its growth and lymphatic flow may be obstructed and altered by the tumor or lymph node metastases themselves [33].…”

Section: Discussionmentioning

confidence: 99%

Sentinel Lymph Node Biopsy in Thyroid Cancer

et al. 2019

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Background Prophylactic central neck dissection in patients with papillary thyroid carcinoma is controversial. Sentinel node biopsy might be an adjunct to optimize surgical treatment for these patients. Earlier studies reported inconsistent detection rates and diagnostic value of this technique, and the role of sentinel lymph node biopsy in thyroid cancer needs to be established. Patients and methods During a single‐center prospective interventional study between 2010 and 2017, sentinel lymph node biopsy using 99mTc‐nanocolloidal albumin tracer was performed on patients undergoing thyroid surgery for suspected thyroid cancer by fine needle aspiration cytology. All eligible patients without clinical lymph node involvement were invited to participate. Central neck dissection was performed on all patients after the detection of sentinel lymph nodes. Results Ninety‐six patients participated in the study. The detection rates of the sentinel node were 67% and 45% by scintigraphy and intraoperative gamma probe, respectively. The detection rate was not associated with Bethesda score, malignancy, or presence of lymph node metastases. Sensitivity, negative predictive value, and accuracy were 80%, 97%, and 98%, respectively, for the sentinel node to represent the status of lymph node metastasis in the central neck compartment. The false negative rate was 20%. Conclusion Sentinel lymph node biopsy had a low detection rate and only moderate sensitivity in patients with suspected thyroid carcinoma and is not a useful adjunct to surgery in the context of current treatment concepts.

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Section: Discussionmentioning

confidence: 99%

Sentinel Lymph Node Biopsy in Thyroid Cancer

et al. 2019

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Neuroendokrine Neoplasien der Kopf-Hals-Region

et al. 2018

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Common to all neuroendocrine neoplasms (NENs), irrespective of their site of origin, is the expression of synaptophysin and chromogranin A. NENs of the head and neck region derive either from epithelial or neural/neuroectodermal tissues. The epithelial-type NENs express cytokeratins and include the well-differentiated typical and atypical carcinoids (also called low- and intermediate-grade neuroendocrine carcinomas by WHO), the poorly differentiated high-grade neuroendocrine carcinomas of small and large cell type and the mixed neuroendocrine-nonneuroendocrine neoplasms. The neural-neuroectodermal-type NENs comprise olfactory neuroblastoma and paraganglioma, each of them with distinct clinicopathological characteristics. Olfactory neuroblastomas show a spectrum of histologic differentiation and are prognostically classified by Hyams grading. Paragangliomas often occur multiple and show a familial background. Most head and neck NENs occur in the upper respiratory system. Their diagnosis follows the general guidelines for NENs, focusing on immunohistochemical profiling. Molecular examinations are so far only required in individual cases.

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Larynx und Hypopharynx

Cited by 2 publications

References 327 publications

Sentinel Lymph Node Biopsy in Thyroid Cancer

Sentinel Lymph Node Biopsy in Thyroid Cancer

Neuroendokrine Neoplasien der Kopf-Hals-Region

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