Larynx Preserving Treatments in the Early and Advanced Laryngeal Cancers; A Retrospective Analysis

Shaghayegh, Kamian; Aghili, Mehdi

doi:10.4172/1948-5956.1000016

Cited by 7 publications

(9 citation statements)

References 5 publications

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“…Kanser tedavi stratejilerindeki ortak amaç tümörün büyümesini kontrol altına alarak yok edilmesini sağlamaktır. Ancak bu süreçte uygulanan tedavi stratejileri aynı zamanda yan etkileri ve diğer organ hasarlarını da beraberinde getirmektedir 15,16 . Bu yüzden günümüzde kanserin tedavisinde alternatif olarak bitkisel kaynaklı bileşiklerin tedavi yaklaşımları araştırılmaktadır.…”

Section: çAlışmamızda Gossypinin Doza Ve Zamana Bağlı Olarak Insan Hepatosellüler Karsinom Hücreleri üZerindeki Antiproliferatif Etkisiniunclassified

Gossypinin insan hepatom (Hep-3B) hücreleri üzerindeki anti-proliferatif etkisi

Çınar

Yayla

Binnetoğlu

2020

Cukurova Medical Journal

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The aim of this study was to demonstrate the antiproliferative effects of Gossypin which has antioxidant, anti-inflammatory, analgesic and anti-cancer properties on human hepatoma (Hep-3B) cells isolated from Hibiscus vitifolius. Materials and Methods: Hep-3B Cell Lines American Type Culture Collection (ATCC, USA) was provided in our study. The cells were exposed to different concentrations (5-100 µg/ml) of gossypin and cisplatine (50µM) as positive control. Afterwards, viability analysis was performed with MTT method on the cells at 24, 48 and 72 hours. Hoechst fluorescent staining was performed for indication of apoptosis in cells. At the same time, RT-PCR and NFκB, caspase 3 and 9 mRNA expression levels were examined. Results: Gossypin administration prevented cell proliferation due to dose and time. In the first 24 hours, only 100µg/ml dose was effective, while in 48 and 72 hours it was effective depending on the dose. With Hoechst fluorescent staining, gossypin showed nearly the same effect as the cisplatin group, with doses of 50 and 100 µg/ml seen to lead the cells to more apoptosis. Gossypin, which inhibits dose dependent NFκB mRNA expression, has also up regulated dose dependent the apoptotic proteins mRNA expression of caspase 3 and 9. Conclusion: Gossypin showed a close effect with cisplatin on Hep-3B cells depending on the dose. These effects were demonstrated by activating apoptosis and inhibiting NFκB. Based on this, gossypin may be a potential anticancer agent in the future for the treatment of liver cancer. Amaç: Çalışmamızda Hibiscus vitifolius'dan izole edilen ve antioksidan, antienflamatuar, analjezik ve anti kanser özelliklere sahip olan gossypinin Hep-3B hücreleri üzerindeki antiproliferatif etkilerini göstermeyi amaçladık. Gereç ve Yöntem: Çalışmamızda Hep-3B hücre hatları American Type Culture Collection (ATCC, USA) temin edilmiştir. Hücreler farklı konsantrasyonlarda (5-100 µg/ml) gossypin ve pozitif kontrol olarak da sisplatine (50µM) maruz bırakılmışlardır. Sonrasında 24, 48 ve 72 saatlerde hücrelere (MTT) yöntemi ile canlılık analizi yapılmıştır. Hücrelerdeki apoptozun göstergesi için Hoechst floresan boyama yapıldı. Aynı zamanda RT-PCR ile Nuklear kappa B (NFκB), kaspaz 3 ve 9 mRNA ekspresyon düzeyleri incelendi. Bulgular: Çalışmamızda gossypin uygulaması doza ve zamana bağlı olarak hücre proliferasyonunu önlemiştir. İlk 24 saatte sadece 100µg/ml dozunda etki gösterirken 48 ve 72. saatlerde ise doza bağlı olarak etkisini göstermiştir. Hoechst floresan boyama ile gossypin 50 ve 100 µg/ml dozunda hücreleri daha belirgin apoptoza götürdüğü görülürken sisplatin grubu ile neredeyse aynı etkiyi ortaya koymuştur. NFκB mRNA ekspresyonunu doza bağlı inhibe eden gossypin, aynı zamanda apoptotik protein olan kaspas 3 ve 9'un mRNA ekspresyonlarını doza bağlı olarak indüklemiştir. Sonuç: Gossypin doza bağlı olarak Hep-3B hücreleri üzerinde sisplatin ile yakın bir etki ortaya koymuştur. Bu etkilerini ise apoptozu aktive ederek ve NFκB inhibisyonu yaparak ortaya koymuştur. Buradan yola çıkarak karaci...

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Section: çAlışmamızda Gossypinin Doza Ve Zamana Bağlı Olarak Insan Hepatosellüler Karsinom Hücreleri üZerindeki Antiproliferatif Etkisiniunclassified

Gossypinin insan hepatom (Hep-3B) hücreleri üzerindeki anti-proliferatif etkisi

Çınar

Yayla

Binnetoğlu

2020

Cukurova Medical Journal

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“…Keganasan laring merupakan tumor ganas kepala dan leher yang banyak dijumpai. 2,3,4 Tumor ganas kepala dan leher yang didapat oleh data dasar tumor ganas nasional 10 tahun terakhir sebanyak 295.000 kasus dan tumor ganas laring merupakan kasus terbesar lebih dari 20% dari keseluruhan tumor ganas kepala dan leher. 5 Data dari American Cancer Society tahun 2011 terdapat penderita tumor ganas laring mencapai 12.740 kasus dengan angka kematian mencapai 3560.…”

Section: Pendahuluanunclassified

“…Dari penelitiannya ada 12 pasien diterapi dengan operasi dan 26 pasien dengan radioterapi, angka kekambuhan pada awal terapi didapatkan 37,5% untuk operasi dan 22% untuk radioterapi, pasien dengan terapi operasi menunjukkan komplikasi lokal sebanyak 25% dan tidak ada menunjukkan komplikasi sistemik, sementara pasien dengan terapi radioterapi menunjukkan komplikasi lokal sebanyak 35% dan komplikasi sistemik sebanyak 27%, sementara untuk biaya terapi dengan radioterapi memperlihatkan biaya yang lebih tinggi dari pada biaya dengan operasi. 4 Angka kekambuhan meningkat pada stadium I-II yang diterapi dengan radioterapi dibandingkan dengan operasi pada stadium yang sama.…”

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Diagnosis dan Penatalaksanaan Karsinoma Sel Skuamosa Glotis Stadium Dini

Rahman¹,

Budiman²,

Swanda³

2016

JKA

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Abstrak Karsinoma laring merupakan tumor ganas kepala leher yang banyak dijumpai. Lebih dari 90% dari seluruh tumor ganas laring adalah karsinoma sel skuamosa, jika terdeteksi lebih dini maka angka keberhasilan pengobatan menjadi lebih baik. Radioterapi merupakan modalitas pilihan pada penatalaksanaan karsinoma laring stadium dini untuk mempreservasi organ dan suara. Diagnosis ditegakkan berdasarkan riwayat perjalanan penyakit, pemeriksaan fisik dan pemeriksaan patologi anatomi. Dilaporkan satu kasus laki-laki berusia 61 tahun dengan diagnosis karsinoma sel skuamosa glotis keratin berdiferensiasi baik stadium IB (T1bN0M0) yang ditatalaksana dengan radioterapi. Kata kunci: Karsinoma sel skuamosa glotis, stadium dini, radioterapi. AbstractLaryngeal carsinoma is the common head and neck cancer. More than 90% of laryngeal cancers are squamous cell carcinoma, if the early detected the cure rate can the better. Radiotherapy is the modality for treatment of laryngeal carcinoma in the early stages to preserve the organ and voice of the patient. The clinical diagnosis is made based on history of illness, physical examination and anatomical pathology examination. Reported One case, man 61 year old, diagnosed with laryngeal squamous cell carcinoma keratinized well differiamted stage IB (T1bN0M0) treated by radiotherapy. Keywords: Glottic squamous cell carsinoma, early stage, radiotherapy.

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“…Treatment like external beam radiation therapy used for liver metastases which has maximum tolerable dose to normal liver parenchyma [76]. Lung tumor can be treated by Intensity Modulated Radiation Therapy [77].Carbon is used in radiotherapy because it has low attenuation properties for the photon energy [78]. Endometrial cancer can only be treated by radiotherapy.…”

Section: Radiation Therapymentioning

confidence: 99%

A Short Note on Cancer

Pudata¹,

Subrahmanyam²

2012

J Carcinogene Mutagene

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Cancer is deadly disease which is caused due to uncontrolled growth of the cells and forms from the extra mass tissue known as tumour. The loss of apoptotic nature by the cells in their metabolic pathway leads to cancer. Cigarette smoking, tobacco intake, alcohol intake, poor diet and exposure to UV rays lead to cancer. Different organs can be effect by cancer cells like lungs, kidney, eyes, heart, brain etc. Cancer cells also spread in blood stream and causes blood cancer. The person who works in the chemical factories, nuclear reactors, drainage system and mining are most prone to cancer. The most cancer causing agents are aluminium, arsenic, radon, lead and lead compounds, titanium dioxide, Ethidium Bromide, Cobalt with tungsten carbide, Welding fumes and Indium phosphide. Treatments such as surgery, chemotherapy and radiation therapy, bone marrow transplantation are used to treat cancer in different stages.

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Larynx Preserving Treatments in the Early and Advanced Laryngeal Cancers; A Retrospective Analysis

Abstract: Background: To assess tumor control and survival of the patients with laryngeal cancers who received chemoradiation or radiotherapy alone as definitive treatment.

Cited by 7 publications

References 5 publications

Gossypinin insan hepatom (Hep-3B) hücreleri üzerindeki anti-proliferatif etkisi

Gossypinin insan hepatom (Hep-3B) hücreleri üzerindeki anti-proliferatif etkisi

Diagnosis dan Penatalaksanaan Karsinoma Sel Skuamosa Glotis Stadium Dini

A Short Note on Cancer

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