“…The NBI system (Olympus Medical System Co., Tokyo, Japan) has been already proven to be a useful diagnostic tool for identifying superficial squamous cell carcinoma of the head and neck [4][5][6][19][20][21]. Trans-nasal endoscopy can usually be performed comfortably due to attenuation of the gag reflex [22]; indeed in Japan, trans-nasal endoscopy is a very common procedure and can be performed without sedation.…”