Laryngoscopic characteristics related to the risk of cancerization of vocal cord leukoplakia

The sensitivity of laryngeal findings in predicting high‐grade dysplasia in patients with vocal fold leukoplakia undergoing office‐based biopsies: A retrospective analysis of 100 cases

“…The authors stressed the need to consider these parameters as independent predictors for the risk of cancerization in vocal fold leukoplakia. 11 The similarity between the results of our review and those documented in the literature can be attributed to the high diagnostic yield of office-based biopsies in comparison with biopsies performed in the operating room under general anesthesia. In 2014, Castillo Farias et al compared the effectiveness of in-office biopsies to direct laryngoscopy in diagnosing pharyngolaryngeal lesions in 88 patients and reported a diagnostic accuracy of 81.8%.…”

“…In a study on 138 patients with 175 vocal cord leukoplakia lesions, Li et al analyzed the relationship between the laryngeal findings and pathological features and found that thick and hyperemic lesions had 3.94 and 23 times the odds of predicting high‐risk transformation, respectively. The authors stressed the need to consider these parameters as independent predictors for the risk of cancerization in vocal fold leukoplakia 11 …”

“…The sensitivity was computed based on the pathological findings of the biopsy taken in the operating room under direct laryngoscopy. Based on many reviews, the sensitivity of the morphological features ranged between 61.4% and 86.3% 8–11 . With the reform in laryngology practice toward office‐based surgery, patients with vocal fold leukoplakia are now invariably offered laryngeal biopsy in an office setting under local anesthesia.…”

“…Based on many reviews, the sensitivity of the morphological features ranged between 61.4% and 86.3%. 8 , 9 , 10 , 11 With the reform in laryngology practice toward office‐based surgery, patients with vocal fold leukoplakia are now invariably offered laryngeal biopsy in an office setting under local anesthesia. Despite the advances in technology in terms of instrumentation, there are still limitations to office‐based laryngeal biopsies, among which are the reduced sensitivity and diagnostic yield secondary to sample size and depth.…”

Laryngoscopy-based scoring system for the diagnosis of vocal fold leukoplakia

“…This characteristic on white-light imaging laryngoscopy, which corresponds to narrow-band imaging laryngoscopy, is observed as tortuous dilated microvessels, and is the main observation point of narrow-band imaging laryngoscopy used to assess the nature of these lesions. 15,16 In order to accurately assess whether vocal fold leukoplakia is hyperaemic, it is critical to observe the vocal fold surface as closely as possible during laryngoscopy and to pay attention to the edge of the leukoplakia. In addition, anterior commissure involvement is closely related to the malignant transformation of vocal fold leukoplakia (assignment of 2 points in our scoring system), which has not been reported in other studies but is consistent with the aggressiveness of the tumours.…”