Laryngopharyngeal motor dysfunction and obstructive sleep apnea in Parkinson’s disease

Bahia, Christianne Martins Corrêa da Silva; Pereira, Joäo Santos; Lopes, Agnaldo José

doi:10.1007/s11325-018-1729-0

Cited by 21 publications

(23 citation statements)

References 30 publications

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“…Four studies reported associated comorbidities such as diabetes, hypertension, and heart diseases. 33,38,44,46 An overlap between Mery (2017), Kaminska (2018), and Meng (2020) was detected. Therefore, we extracted unique outcomes from each study, and in case of repetition, we used the most updated study Meng (2020).…”

Section: Patients and Study Characteristicsmentioning

confidence: 99%

“…36,37 Furthermore, a few studies compared PD patients who had OSA (PD + OSA) with PD patients who did not have OSA (PD -OSA), and the comparison included motor and/or cognitive functions. 11,33,[38][39][40][41][42][43][44][45][46] Due to the discrepancy between the results of such studies, we conducted this systematic review and meta-analysis to assess how OSA influences both motor and cognitive functions in PD patients.…”

Section: ---------------------------------------------------------mentioning

confidence: 99%

“…Seven studies 11,33,[38][39][40]42,43 assessed UPDRS III in PD + OSA patients in comparison with PD -OSA ones. The random-effect estimate of these seven studies (n = 738 patients) demonstrated that the UPDRS III score was significantly higher in the PD + OSA group (MD = 1.63, 95% CI [0.03, 3.23], P = 0.049).…”

Section: Pd Severity: Updrs and Handy Scalementioning

confidence: 99%

“…H&Y scale was assessed in eight studies. 33,[38][39][40][41][43][44][45] The overall fixed-effect estimate of these eight studies (n = 813 patients) showed that there was no significant difference between PD + OSA patients and PD -OSA patients in terms of the H&Y scale (MD = 0.06, 95% CI [−0.04, 0.15], P = 0.26). Pooled studies were not homogenous (P = 0.05, I 2 = 50%).…”

Section: Pd Severity: Updrs and Handy Scalementioning

confidence: 99%

“…Additionally, data from nine studies 11,33,[38][39][40][41][42][43][44] (n = 875 patients) showed that PD + OSA patients were on a lower level of L-dopa equivalent dose (MD = −58.63 mg/dL, 95% CI [−103.93, −13.34], P = 0.01). Pooled studies were not homogenous (P = 0.01, I 2 = 58%).…”

Section: Pd Severity: Updrs and Handy Scalementioning

confidence: 99%

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Impact of Obstructive Sleep Apnea on Cognitive and Motor Functions in Parkinson's Disease

et al. 2020

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A BS TRACT: Introduction: Parkinson's disease (PD) is a chronic neurodegenerative disorder that presents with motor and non-motor manifestations. Amongst the nonmotor features, various forms of sleep disturbances can occur, and obstructive sleep apnea (OSA) is considered to be a common comorbidity. We conducted this systematic review and meta-analysis to assess the impact of OSA on cognitive and motor functions in PD. Methods: The information sources of for this systematic review and meta-analysis were PubMed, SCOPUS, Web of Science, and ScienceDirect. Studies meeting the following criteria were included: (1) studies including idiopathic PD patients, (2) studies using polysomnography to categorize PD patients into PD with OSA and PD without OSA, and (3) studies with observational designs (casecontrol, cohort, or cross-sectional). Data analysis was performed using RevMan. Results: Our meta-analysis showed that OSA was associated with significantly lower scores of Montreal Cognitive Assessments (MoCA) (mean difference (MD) = −0.70, 95% confidence interval (CI) [−1.28, −0.13], P = 0.01) and Mini-Mental State Examination (MMSE) (MD = −0.69, 95% CI [−1.17, −0.21], P = 0.005). Moreover, the score of the motor part of the Unified Parkinson's Disease Rating Scale (UPDRS III) was significantly higher in PD patients with OSA as compared with those without OSA (MD = 1.63, 95% CI [0.03, 3.23], P = 0.049). Conclusions: OSA is associated with increased severity of PD-associated cognitive dysfunction and motor symptoms. However, further studies are needed to corroborate these findings, assess the underlying mechanisms by which OSA influences the motor and cognitive functions in PD, and investigate whether OSA can accelerate the neurodegenerative process of PD.

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