Laryngopharyngeal Mass in a Dog with Upper Airway Obstruction

Barnhart, Kirstin; Lewis, Barbara C.

doi:10.1111/j.1939-165x.2000.tb00397.x

Cited by 14 publications

(22 citation statements)

References 15 publications

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“…Cytologic findings of rhabdomyomas have only rarely been described in the veterinary literature. In a report by Barnhart and Lewis 5 involving a laryngeal rhabdomyoma in a dog, a mixture of 2 morphologically distinct cell populations was described, similar to the present case. However, spindle‐shaped cells and strap‐like cells were not observed, and the primary differential diagnoses were oncocytoma or thyroid carcinoma.…”

Section: Discussionsupporting

confidence: 82%

“…Special stains, immunohistochemistry, and electron microscopy may also be helpful in distinguishing skeletal muscle tumors from oncocytomas and granular cell tumors. Cells from rhabdomyosarcomas, rhabdomyomas, and oncocytomas may contain numerous mitochondria and stain positive for PTAH; however, oncocytoma cells do not have cross‐striations 5 . Granular cell tumors contain numerous lysosomes and are typically PTAH negative and PAS positive, while skeletal muscle tumors and oncocytomas are PAS negative 5 .…”

Section: Discussionmentioning

confidence: 99%

“…Cells from rhabdomyosarcomas, rhabdomyomas, and oncocytomas may contain numerous mitochondria and stain positive for PTAH; however, oncocytoma cells do not have cross‐striations 5 . Granular cell tumors contain numerous lysosomes and are typically PTAH negative and PAS positive, while skeletal muscle tumors and oncocytomas are PAS negative 5 . With immunohistochemistry, most oncocytomas are cytokeratin‐positive only, while granular cell tumors may be positive for vimentin, cytokeratin, S‐100, and rarely desmin 5,12 .…”

Section: Discussionmentioning

confidence: 99%

“…Granular cell tumors contain numerous lysosomes and are typically PTAH negative and PAS positive, while skeletal muscle tumors and oncocytomas are PAS negative 5 . With immunohistochemistry, most oncocytomas are cytokeratin‐positive only, while granular cell tumors may be positive for vimentin, cytokeratin, S‐100, and rarely desmin 5,12 . The staining characteristics of rhabdomyomas are similar to rhabdomyosarcomas, depending on the degree of maturation of the neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

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What is your diagnosis? Lingual mass in a dog

Chapman

Nabity

Calise

2008

Veterinary Clinical Pathol

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A 3.5-year-old female spayed Rat Terrier was presented for evaluation of a submucosal lingual mass. Fine-needle aspiration of the mass revealed a population of neoplastic cells composed predominantly of small, round cells and large, round to spindle-shaped cells, which occasionally had blunt cytoplasmic borders and multiple nuclei. The neoplastic cells had moderate to marked anisocytosis and anisokaryosis. The cytologic interpretation was malignant neoplasia, most likely sarcoma. Histopathologic examination of a biopsy specimen revealed an unencapsulated, poorly demarcated, moderately cellular neoplasm composed of individualized, infiltrative spindle cells. Elongate skeletal muscle cells with prominent, rectangular borders (strap cells) were observed. A morphologic diagnosis of rhabdomyosarcoma was made. Staining with phosphotungstic acid-hematoxylin revealed haphazardly arranged skeletal muscle cross-striations. Immunohistochemical staining results for vimentin, Myo D1, desmin, and myoglobin were positive, though staining intensity of tumor cells varied with the degree of differentiation. Using transmission electron microscopy, irregular, disorganized Z-bands were identified. Rhabdomyosarcomas are uncommon tumors in the dog, and rarely may involve the tongue or oral cavity. Cytologic evaluation of a rhabdomyosarcoma may reveal a pleomorphic population of cells and definitive diagnosis may require histologic examination, immunohistochemical staining, and electron microscopy.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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What is your diagnosis? Lingual mass in a dog

Chapman

Nabity

Calise

2008

Veterinary Clinical Pathol

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“…In general, these tumors resemble their counterparts arising in more common sites, although oncocytomas and rhabdomyomas may be difficult to differentiate without the use of additional diagnostics such as electron microscopy or immunohistochemical staining for desmin, myoglobin, or actin (Table 5-3). Definitive diagnosis of muscle origin tumors is best accomplished with immunohistochemical staining for desmin, myoglobin, or actin (Barnhart and Lewis, 2000;Meuten et al, 1985). 5-25A-C) have plump, large cells with abundant granular or foamy to vacuolated cytoplasm.…”

Section: Mesenchymal Neoplasiamentioning

confidence: 99%