Laryngeal vibration as a non-invasive neuromodulation therapy for spasmodic dysphonia

Khosravani, Sanaz; Mahnan, Arash; Yeh, I-Ling; Aman, Joshua E.; Watson, Peter J.; Zhang, Yang; Goding, George S.; Konczak, Jürgen

doi:10.1038/s41598-019-54396-4

Cited by 25 publications

(26 citation statements)

References 60 publications

(68 reference statements)

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“…The main surgical alternative to botulinum toxin injection is selective laryngeal adductor denervationreinnervation (SLAD-R) surgery which, though first described in 1999, has not been widely adopted by the laryngology community. 6,7 More recently, novel treatments such as sodium oxybate for alcohol responsive patients, 8 neuromodulation of laryngeal innervation with an implantable electrical stimulator device or a vibration collar, 9,10 and laser thyroarytenoid myoneurectomy 11 have been described with encouraging preliminary outcomes but limited long-term results. Outcomes reported for these treatments were measured by tools not validated to accurately represent the severity of the impact of SD on patients' daily communication function.…”

Section: Introductionmentioning

confidence: 99%

Validation of the Communicative Participation Item Bank as an Outcome Measure for Spasmodic Dysphonia

et al. 2020

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Objectives: Current patient-reported outcome measures do not adequately capture the impact of spasmodic dysphonia (SD) on communication in daily life situations. The aim of this study was to validate the Communicative Participation Item Bank (CPIB), which specifically measures a disease's impact on daily conversational situations, as an outcome measure for SD. Study Design: Multi-institutional prospective cohort study. Methods: A prospective study was conducted with administration of the 46-question CPIB and the Voice Handicap Index-10 (VHI-10) to 190 participants with SD before (time 1) and 6 weeks after (time 2) botulinum toxin injection. Differential item function (DIF) analyses were performed to examine potential item bias. Paired t-tests were used to assess change in each of the CPIB and VHI-10 scores after treatment. Pearson correlations were calculated between the CPIB and VHI-10. Results: DIF analyses revealed no clinically meaningful difference between the item parameters generated for this SD sample and the original CPIB calibration sample. There were statistically significant changes between the pre-treatment and post-treatment time points for both the CPIB and VHI-10. Correlations between the CPIB and VHI were moderate-high. Conclusions: The CPIB item bank, General Short Form, and scoring parameters can be used with people with SD for valid and reliable measurement of the impact of communication disorders on communication in everyday life. The CPIB is sensitive to changes with intervention, proving useful for clinical and research purposes to assess the efficacy and effectiveness of interventions.

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Section: Introductionmentioning

confidence: 99%

Validation of the Communicative Participation Item Bank as an Outcome Measure for Spasmodic Dysphonia

et al. 2020

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“…sensory tricks) is known to ameliorate dystonic symptoms in some FD patients, and sensory retraining was able to improve motor function in TSFD of the hand in the past 29 . Quite recent work in FLD already made steps in this direction, indicating positive modulatory effects on voice function through ventral cervical cutaneous vibration 30 , hence the investigation of effects of sensory retraining strategies applied to nondystonic/surrogate sensory areas might be of interest for future work.…”

Section: Discussionmentioning

confidence: 99%

Altered sensory system activity and connectivity patterns in adductor spasmodic dysphonia

Mantel

Dresel

Welte

et al. 2020

Sci Rep

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Adductor-type spasmodic dysphonia (ADSD) manifests in effortful speech temporarily relievable by botulinum neurotoxin type A (Bont-A). previously, abnormal structure, phonation-related and resting-state sensorimotor abnormalities as well as peripheral tactile thresholds in ADSD were described. this study aimed at assessing abnormal central tactile processing patterns, their spatial relation with dysfunctional resting-state connectivity, and their Bont-A responsiveness. functional MRI in 14/12 ADSD patients before/under BoNT-A effect and 15 controls was performed (i) during automatized tactile stimulus application to face/hand, and (ii) at rest. Between-group differential stimulation-induced activation and resting-state connectivity (regional homogeneity, connectivity strength within selected sensory(motor) networks), as well as within-patient BoNT-A effects on these differences were investigated. Contralateral-to-stimulation overactivity in ADSD before BoNT-A involved primary and secondary somatosensory representations, along with abnormalities in higherorder parietal, insular, temporal or premotor cortices. Dysphonic impairment in ADSD positively associated with left-hemispheric temporal activity. connectivity was increased within right premotor (sensorimotor network), left primary auditory cortex (auditory network), and regionally reduced at the temporoparietal junction. Activation/connectivity before/after BoNT-A within-patients did not significantly differ. Abnormal ADSD central somatosensory processing supports its significance as common pathophysiologic focal dystonia trait. Abnormal temporal cortex tactile processing and resting-state connectivity might hint at abnormal cross-modal sensory interactions.

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“…The device, named "MyVoicePlus", was presented as being considered for possible commercial and/or clinical deployment by a French startup company. The cover story included mock photographs of the device (consisting of both an in-ear prosthesis and a larynx piece, disguised as jewelry), as well as references to technical voice-transformation literature (e.g., [28]) allegedly describing the algorithms implemented in the device (see Supplementary Material). Participants were told that the startup was commissioning the study to evaluate the societal acceptability of their technology in various usage scenarios, and that their collective judgements would condition the deployment of the technology.…”

Section: Methodsmentioning

confidence: 99%

The shallow of your smile: The ethics of expressive vocal deepfakes

Guerouaou¹,

Vaïva²,

Aucouturier³

2021

Preprint

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Rapid technological advances in artificial intelligence are creating opportunities for real-time algorithmic modulations of a person’s facial and vocal expressions, or “deep- fakes”. These developments raises unprecedented societal and ethical questions which, despite much recent public awareness, are still poorly understood from the point of view of moral psychology. We report here on an empirical study conducted on N=303 online participants, who evaluated the acceptability of vignettes describing potential applications of expressive voice transformation technology. We found that vocal deep- fakes were generally well accepted in the population, notably in a therapeutic context and for emotions judged otherwise difficult to control, and surprisingly, even if the user lies to their interlocutors about using them. Unlike other emerging technologies like autonomous vehicles, there was no evidence of social dilemma in which one would e.g. accept for others what they resent for themselves. The only real obstacle to the massive deployment of vocal deep-fakes appears to be situations where they are applied to a speaker without their knowing, but even the acceptability of such situations was modulated by individual differences in moral values and attitude towards science- fiction.

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Laryngeal vibration as a non-invasive neuromodulation therapy for spasmodic dysphonia

Cited by 25 publications

References 60 publications

Validation of the Communicative Participation Item Bank as an Outcome Measure for Spasmodic Dysphonia

Validation of the Communicative Participation Item Bank as an Outcome Measure for Spasmodic Dysphonia

Altered sensory system activity and connectivity patterns in adductor spasmodic dysphonia

The shallow of your smile: The ethics of expressive vocal deepfakes

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