Laryngeal swabs for diagnosing tuberculosis

Thakur, A.; Coulter, J. B. S.; Zutshi, Kiran; Pande, Hemant; Sharma, Maddie; Banerjee, Ashis; Richardson, Kay

doi:10.1080/02724939992167

Cited by 15 publications

(6 citation statements)

References 6 publications

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“…21 A recent study of laryngeal swabs in Indian children found a positive smear/ culture in 33%. 22 The yield from examining laryngeal swabs in this study was very low.…”

Section: Discussionmentioning

confidence: 94%

Diagnosis of pulmonary tuberculosis in children in an HIV-endemic area, Malawi

et al. 2001

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The diagnosis of pulmonary tuberculosis (PTB) in young children is particularly complex in resource-poor regions where HIV infection is common. This study examines the impact of HIV infection on diagnosis in children with suspected PTB attending Queen Elizabeth Central Hospital, Blantyre. A total of 110 children (4 months-14 years) were studied over a 4-month period. Clinical data were recorded and investigations included Mantoux test, chest X-ray, HIV status (HIV-PCR when younger than 18 months) and sputum, if available. Laryngeal swabs were compared with sputa or gastric aspirates in a subgroup of 60 children. All children were commenced on anti-TB therapy and followed for treatment response. Aware of the clinical overlap between HIV and TB infection, we used more limited criteria than recommended to allocate a final diagnosis following review of all data except HIV status. Final diagnosis included confirmed PTB (n = 8), probable PTB (n = 41), lymphocytic interstitial pneumonitis (n = 10), pulmonary Kaposi sarcoma (n = 3) and bronchiectasis (n = 5). Culture rates of M. tuberculosis were: five (27.8%) of 18 sputa, three (7.1%) of 42 gastric aspirates and four (6.6%) of 60 laryngeal swabs. The HIV infection rate was 70.6% overall and 57.8% in 45 children with confirmed or probable PTB. Although a positive contact history was more common in HIV-infected children, a final diagnosis of confirmed or probable PTB was less common than in HIV-uninfected children (36% vs 63%; p = 0.02). The Mantoux test was positive in 14 (19%) of 72 HIV-infected compared with 15 (50%) of 30 HIV-uninfected children (p < 0.01). A final diagnosis could not be made in 43 (39%) of the study children with suspected PTB, the majority of whom were HIV-infected. HIV-infected children had a significantly poorer response to TB treatment and higher lost-to-follow-up rates.

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“…21 A recent study of laryngeal swabs in Indian children found a positive smear/ culture in 33%. 22 The yield from examining laryngeal swabs in this study was very low.…”

Section: Discussionmentioning

confidence: 94%

Diagnosis of pulmonary tuberculosis in children in an HIV-endemic area, Malawi

et al. 2001

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“…In this case, positive findings on chest radiographs helped in making a provisional diagnosis and initiating treatment. Acid‐fast smear and culture of laryngeal swabs is of value in confirming pulmonary tuberculosis in cases of negative sputum smears [15].…”

Section: Discussionmentioning

confidence: 99%

Tuberculous osteomyelitis of the mandible: a case report

Bhatt

Jayakrishnan

2001

Int J Paed Dentistry

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Osteomyelitis of jaws caused by infection with Mycobacterium tuberculosis is uncommon, especially in children. We present a case of tuberculous osteomyelitis in a young child. Its clinical presentation, with features similar to a dento-alveolar abscess, underline the importance of considering it in the differential diagnosis of jaw lesions. We discuss of the diagnostic techniques, management and preventive measures, and stress the importance of history taking during clinical examination.

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“…From included manuscripts (appendix pp 26–33 for study characteristics; appendix p 5 includes full methodological details and results by study), we classified types of upper respiratory tract sampling into four groups: laryngeal swabs (32 studies 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ), nasopharyngeal aspirate (ten studies 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ), oral swabs (18 studies 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ), and other (mouthwash three studies, 71 , 72 , 73 nasal swabs one study, 74 saliva four studies, 75 , 76 , 77 ,…”

Section: Resultsmentioning

confidence: 99%

Accuracy of upper respiratory tract samples to diagnose Mycobacterium tuberculosis: a systematic review and meta-analysis

Savage,

Rickman,

Burke

et al. 2023

The Lancet Microbe

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Laryngeal swabs for diagnosing tuberculosis

Cited by 15 publications

References 6 publications

Diagnosis of pulmonary tuberculosis in children in an HIV-endemic area, Malawi

Diagnosis of pulmonary tuberculosis in children in an HIV-endemic area, Malawi

Tuberculous osteomyelitis of the mandible: a case report

Accuracy of upper respiratory tract samples to diagnose Mycobacterium tuberculosis: a systematic review and meta-analysis

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