Laryngeal Solitary Fibrous Tumor Treated with a Transcervical Approach

Yamaguchi, Nimpei; Komuro, Satoru; Kumagami, Hidetaka; Iwanaga, Tetsu; Takahashi, Haruo

doi:10.1016/j.otohns.2009.03.032

Cited by 5 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Atypical histological features (e.g. hypercellularity and raised mitotic activity) are exceedingly rare in the the larynx [18,26]. The present is the third case of atypical laryngeal SFT, although the term ''atypical'' does not determine the tumor's behavior.…”

Section: Conflict Of Interestmentioning

confidence: 74%

“…In the revised series, complete tumor excision was curative in all cases, without evidence of disease during the follow-up. Similarly, those cases defined as atypical due to hyperellularity and increased mitotic count had a disease-free follow-up [18,26]. Furthermore, it should be considered that defining the primary site as laryngeal or hypopharyngeal can affect the surgical approach.…”

Section: Diagnostic Workflow and Managementmentioning

confidence: 99%

“…The vascular network was characterized by thin-walled, non-fibrotic vessels motility. In the subglottic region SFT caused airways' narrowing and dyspnoea [15,18]. Some supraglottic lesions can secondarily involve the hypopharynx, additionally causing dysphagia.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Untitled

2022

J Otolaryngol Rhinol

View full text Add to dashboard Cite

The present review is based on a critical literature revision and aimed to identify the overall clinical behavior of laryngeal solitary fibrous tumor (SFT). Laryngeal hemangiopericytomas (HPC) were included, according to both their re-classification as the SFT's cellular variant and the NAB2-STAT6 fusion gene. A case series was builded including a new case and other 30 previously published cases of laryngeal SFTs (Medline 1956 to 2021) with comparative purpose. Immunohistochemistry and molecular analysis were performed on the new case. The clinical features of such case series showed a peculiar behavior of SFT, characterized by 1) Early symptomatic onset 2) Small size at diagnosis 3) Prevalent supra-glottic location 4) Impairment of the quality of voice with vocal muscle sparing 5) Favorable clinical outcome after complete surgical excision, since no distant metastases were reported in the literature. Furthermore, atypical histologic features were infrequently described. As seen in the pleural counterpart and in other extra-pleural locations, laryngeal SFT harboured NAB2-STAT6 gene fusion and showed a strong nuclear immunostaining for STAT6, as confirmed by the herein described case. According to its peculiar clinicalpathologic behavior, the risk stratification models that have been proposed for SFT are not suitable for the larynx.

show abstract

Section: Conflict Of Interestmentioning

confidence: 74%

Section: Diagnostic Workflow and Managementmentioning

confidence: 99%