Laryngeal Secretions:<i>An Immunochemical and Immunohistological Study</i>

Mogi, Goro; Watanabe, Noritake; Maeda, Shoichi; Umehara, Takahiro

doi:10.3109/00016487909126397

Cited by 32 publications

(19 citation statements)

References 20 publications

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“…This liquid serves as a physical and biochemical barrier to protect the underlying tissue from damage from inhaled particulates and pathogens [1]. The surface liquid is also important for maintaining optimal biomechanical characteristics of the vocal fold mucosa, increasing efficiency of vocal fold oscillation, and promoting voice quality [2].…”

Section: Introductionmentioning

confidence: 99%

Localization and regulation of aquaporins in the murine larynx

Ahmed¹,

Bando²,

Hirota³

et al. 2012

Acta Oto-Laryngologica

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AQP1, 4, and 5 were expressed in the laryngeal epithelium including the vocal folds. Vocal fold AQP expression was minimal at the vocal process. AQP2, 3, 5, 6, 7, and 8 were localized to the submucosal glands. Expression of AQPs in the vagotomized region was significantly decreased compared with the contralateral intact side. The expression in the laryngeal glands was also decreased in the aged mice.

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Section: Introductionmentioning

confidence: 99%

Localization and regulation of aquaporins in the murine larynx

Ahmed¹,

Bando²,

Hirota³

et al. 2012

Acta Oto-Laryngologica

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“…This liquid serves as a physical and biochemical barrier that protects the underlying tissue from damage from inhaled particulates and pathogens 2. Presence of surface liquid is also posited to maintain optimal biomechanical characteristics of vocal fold mucosa, increase efficiency of vocal fold oscillation, and promote normal voice quality 1,.…”

Section: Introductionmentioning

confidence: 99%

Vocal Fold Surface Hydration: A Review

Leydon

Sivasankar²,

Falciglia

et al. 2009

Journal of Voice

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Vocal fold surface liquid homeostasis contributes to optimal vocal physiology. In this paper we review emerging evidence that vocal fold surface liquid is maintained in part by salt and water fluxes across the epithelium. Based on recent immunolocalization and electrophysiological findings, we describe a transcellular pathway as one mechanism for regulating superficial vocal fold hydration. We propose that the pathway includes the sodium-potassium pump, sodium-potassium-chloride cotransporter, epithelial sodium channels, cystic fibrosis transmembrane regulator chloride channels, and aquaporin water channels. By integrating knowledge of the regulating mechanisms underlying ion and fluid transport with observations from hydration challenges and treatments using in vitro and in vivo studies, we provide a theoretical basis for understanding how environmental and behavioral challenges and clinical interventions may modify vocal fold surface liquid composition. We present converging evidence that clinical protocols directed at facilitating vocal fold epithelial ion and fluid transport may benefit healthy speakers, those with voice disorders, and those at risk for voice disorders.

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“…44,45 Additionally, vocal fold surface fluid protects the underlying mucosa from inhaled particulate. 46 Irritant receptors in laryngeal mucosa are sensitive to changes in surface ion composition. 15,16,32 Here, we provide evidence for prompt detection of perturbations to luminal ionic composition even in deinnervated, viable vocal folds.…”

Section: Discussionmentioning

confidence: 99%