Laryngeal Reinnervation Using Ansa Cervicalis for Thyroid Surgery-Related Unilateral Vocal Fold Paralysis: A Long-Term Outcome Analysis of 237 Cases

Wang, Wei; Chen, Donghui; Chen, Shicai; Li, Ding; Lv, Meng; Xia, Siwen; Zheng, Hongliang

doi:10.1371/journal.pone.0019128

Cited by 96 publications

(87 citation statements)

References 26 publications

(49 reference statements)

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“…The rate of major complications involving airway compromise was low (2 of 237 patients). None of these patients developed paradoxical vocal fold mobility (15).…”

Section: Voice Outcomesmentioning

confidence: 90%

“…The most common technique reported is nerve-to-nerve anastomosis employing ansacervicalis as the donor nerve as described by Crumley (ansa-RLN) (14). Wang et al (15) had Editorial improved the technique by using the main branch of the ansa cervicalis that has more axons to regenerate to the injured RLN instead of ansa hypoglossi to sternohyoid, and they described details of the surgery for a successful reinnervation.…”

Section: Laryngeal Reinnervationmentioning

confidence: 99%

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Non-Selective Laryngeal Reinnervation for Unilateral Vocal Fold Paralysis

Baki¹

2016

JSA

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“…The rate of major complications involving airway compromise was low (2 of 237 patients). None of these patients developed paradoxical vocal fold mobility (15).…”

Section: Voice Outcomesmentioning

confidence: 90%

Section: Laryngeal Reinnervationmentioning

confidence: 99%

Non-Selective Laryngeal Reinnervation for Unilateral Vocal Fold Paralysis

Baki¹

2016

JSA

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Section: Peripheral Nerve Regeneration -From Surgery To New Therapeutmentioning

confidence: 99%

“…Recent treatment methods include thyroplasty, laser arytenoidectomy and cordectomy. The recovery success of the RLN depends on early diagnosis and early exploration of the nerve [77][78][79].The treatment of SLN injury includes voice therapy, type 1 or 4 thyroplasty and reinnervation using nerve muscle pedicle technique. There are no studies which extensively investigated the success of these therapeutic methods for SLN injury [80][81][82][83].…”

mentioning

confidence: 99%

Peripheral Nerve Injury and Current Treatment Strategies

Tezcan¹

2017

Peripheral Nerve Regeneration - From Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies Deve

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Neuronal cells are the main fundamental anatomic unit of the system. Nerve injuries are generally divided into three categories as neuropraxia, axonotmesis and neurotmesis. Neurotmesis is the most severe form. Schwann cells are activated within 24 hours of the injury and the healing cascade continued with the cells, which are stimulated by Schwann cells. And neurotrophic factors like nerve growth factor (NGF) have a crucial role in regeneration and degeneration processes. Additionally, Schwann cells upregulate the expression of some proteins, such as fibronectin, which are crucial for axonal regeneration. All this information about nerve healing sheds light on treatment studies. Iatrogenic nerve injury has an important place in peripheral nerve injury. Causes may be direct surgical damage, wrong intraoperative patient positioning, anaesthesiarelated reasons or limb tourniquets. Typical symptoms are motor or sensory deficits such as paraesthesia, weakness, paralysis and pain. Many of the traumatic nerve injuries require surgical repair. Direct nerve repair and autologous nerve grafts are still goldstandard treatment options. Additionally, nerve conduits are very successful to provide an ideal peripheral support for neuronal recovery but are still insufficient. In recent years, research efforts have focused on the neurotrophic factors and cell-based therapies to perform better microenvironment for neuronal healing.Keywords: peripheral nerve, injury, iatrogenic, nerve grafts, conduit, cell-based therapy IntroductionAn injury to a nerve can result in a problem with the muscle innervation or in a loss of sensation. In some people, it can also cause pain. The type of nerve injury will determine the type of treatment that will be needed. Peripheral nerve injuries (PNIs) affect all age groups and have many causes like trauma and medical disorders. The majority of the peripheral nerve injuries © 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.(PNI) occur in the upper extremity and are secondary to trauma [1]. Typical symptoms are motor or sensory deficits such as paraesthesia, weakness, paralysis and pain [2]. Many of the traumatic nerve injuries require surgical repair. The primary goal of the repair is to achieve the reinnervation of the target organs, but the therapeutic options which are used at present cannot achieve perfect sensory and motor recovery in all cases. In this chapter, the pathophysiology and mechanisms of nerve injuries, the traumatic nerve injuries, especially the iatrogenic forms, and therapeutic options for the peripheral nerve injuries will be discussed. Peripheral nerve anatomyPeripheral nervous system consists of neuronal cells, glial cells and stromal cells. Neuronal cells are the main fundamental anatomic unit of the system. Neurons conduct elec...

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“…But this operative standard still results in a 4% to 8% incidence of initial postoperative RLN paralysis; with continued follow up, the RLN frequently recovers function, resulting in a permanent paralysis rate of 1% to 2% [4][5][6][7]. The most common laryngoscopic findings in unilateral vocal fold paralysis beyond vocal fold motion impairment include bowing, incomplete glottal closure, and phase asymmetry on videostroboscopy [14].The position of the vocal fold (eg, paramedian vs lateral) does not necessarily clarify the location of the lesion along the neurologic pathway from brain to motion of vocal fold [15] II.…”

Section: Introductionmentioning

confidence: 99%