Laryngeal Nodes and the so-called Amyloid Tumour of the Cords

Kelly, Hazel; Craik, J. E.

doi:10.1017/s0022215100047794

Cited by 13 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The microscopist's difficulty in dis-393 tinguishing interstitially deposited fibrin from amyloid has not been adequately appreciated, the observations of Kelly and Craik (1952) on 'laryngeal nodes and so-called amyloid tumour of the cords' standing almost alone in this context. We certainly have found several singer's nodes and other benign nodules of the larynx to be eloquent examples of fibrinous vasculosis.…”

Section: Part IIImentioning

confidence: 99%

Renal hyalin

1972

View full text Add to dashboard Cite

SYNOPSIS This describes the sodium sulphate-Alcian Blue (SAB) method for staining amyloid in paraffin sections. Its value lies in the possibility of subsequent counterstaining and thus of revealing the structural relationships of amyloid.In the kidney the topical disposition of amyloid closely resembles the disposition of fibrin in the kidney of diabetics; this suggests that upset in vascular permeability plays a part in determining the site of the amyloid deposits. Furthermore, an aging process in amyloid can now be envisaged resembling the aging of extraluminal fibrin. Both materials proceed to a hyalin material that, staining like collagen, merits the name pseudo-collagen. This term we apply to a hyalin, staining like collagen, for which,we can postulate a specific precursor.The I ight microscopist has generally accepted amyloid as a hyalin substance, an acellular firm gel, situated interstitially, and distinguished from other hyalins by particular staining reactions, notably the metachromatic reaction with methyl violet and an affinity for Congo red. Neither of these methods is ideal for the study of the structural relationships of amyloid.Our attempts to demonstrate and study amyloid, as seen in postmortem material, were progressing unprofitably when suddenly one divagation revealed possibilities. A rationally evolved although perhaps inaccurate idea led one of us (W.S.) to produce a modified Alcian Blue solution. This enabled us to stain amyloid, in sections from paraffin, with a dye that could be stabilized in situ and thus allow a variety of counterstainings. Although, as with most other dye-staining methods, the results were not chemically specific for amyloid, with suitable counterstaining they proved sufficiently selective to allow study of the precise situation of the amyloid deposits. Unfortunately the dye makers, in 1955, changed the constitution of the dye, and our results altered miserably.

show abstract

Section: Part IIImentioning

confidence: 99%

Renal hyalin

1972

View full text Add to dashboard Cite

show abstract

“…Although Congo red was introduced by Bennhold (1922) as a stain for amyloid, Ladewig (1945), Stark and McDonald (1948), Dahlin (1949), Montgomery and Muirhead (1954), Symmers (1956), Montgomery and Muirhead (1957), Pearse (1960), andMcAlpine et al (1963) all reported non-specific staining reactions of various normal and pathological tissue constituents, particularly hyaline deposits and hyalinized collagen. In the present study most of the hyaline deposits in the polyps were negative when using Highman's technique (1946), or a few showed a low affinity for Congo red, but specimens of hyalinized collagen showed a moderate affinity for the stain.…”

Section: Discussionmentioning

confidence: 99%

“…The alcoholic solution of Congo red, as used in Highman's method, gives some degree of selectivity between hyaline and amyloid, but even the results of this better method should be interpreted with caution and used in conjunction with other methods. Ladewig (1945) reported that Congo-red-stained amyloid became birefringent when examined with polarized light. He also reported that other nonamyloid substances (hyalines, mucins, fibrinoid, and elastic tissue), which also stain with the dye, showed no birefringence.…”

Section: Discussionmentioning

confidence: 99%

“…Epstein, Winston, Friedmann, and Ormerod (1957) found no metachromatic staining in hyalinized vocal cord polyps which showed some affinity for Congo red. Kelly and Craik (1952) omitted methyl violet metachromasia from their study of hyalinized laryngeal polyps on the grounds that the stain was not permanent. It must be stressed here that metachromasia must always be assessed on any homogeneous eosinophilic deposit or hyalinized material suspected of being amyloid, even though the method does suffer from impermanence.…”

Section: Polarization Microscopy Of Congo Red-stainedmentioning

confidence: 99%

See 1 more Smart Citation

A histological study of hyaline deposits in laryngeal, aural, and nasal polyps and their differentiation from amyloid

McAlpine¹,

Bancroft²

1964

Journal of Clinical Pathology

View full text Add to dashboard Cite

In a recent study of localized amyloidosis of the respiratory tract, McAlpine, Radcliffe, and Friedmann (1963) discussed the methods of distinguishing amyloid from other varieties of hyaline substances. They concluded that a homogenous acellular eosinophilic substance which showed metachromasia, strong affinity for Congo red, birefringence and dichroism if stained with Congo red, no birefringence or dichroism if unstained, strong fluorescence in ultra-violet light if stained with Thioflavin T, and a high degree of resistance to pepsin extraction was characteristic of amyloid. However, it was pointed out that the Thioflavin T method had not been subjected to an extensive control study using hyaline (non-amyloid) deposits.In localized laryngeal amyloidosis the main histological differential diagnosis is from areas of hyalinization occurring in laryngeal polyps. In many cases these areas are indistinguishable from amyloid when stained with haematoxylin and eosin. Further they also show a strong affinity for Congo red, which 'Present address:

show abstract

“…The majority of cases have been amyloid tumours of the larynx or vocal cords, which, according to Ash and Schwartz (1944), and Kelly and Craik (1952), are often misnamed and would be better described as hyaline nodes. In 1948 Stark and McDonald re-examined the respiratory tract amyloid tumours in the surgical files of the Mayo Clinic.…”

mentioning

confidence: 99%

Localized Amyloid Infiltrations of the Lower Respiratory Tract

Whitwell¹

1953

Thorax

View full text Add to dashboard Cite

Laryngeal Nodes and the so-called Amyloid Tumour of the Cords

Cited by 13 publications

References 14 publications

Renal hyalin

Renal hyalin

A histological study of hyaline deposits in laryngeal, aural, and nasal polyps and their differentiation from amyloid

Localized Amyloid Infiltrations of the Lower Respiratory Tract

Contact Info

Product

Resources

About