Laryngeal metastasis from lung cancer

Kalai, Umasankar; Madan, Karan; Jain, Deepali; Mohan, Anant; Guleria, Randeep

doi:10.4103/0970-2113.156249

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…Lung cancer prognosis is closely related to metastasis. Common lung cancer metastasis sites are bone and brain ( 9 ), while other metastatic sites include liver ( 10 ), duodenum and pancreas ( 11 ), lymph node ( 12 ), adrenal gland ( 13 ), throat ( 14 ), and eye ( 15 ), with the eye a rare site for lung cancer metastasis. Clinical manifestations of ocular metastases include decreased vision, visual field defects, pain, muscae volitantes, and elevated intraocular pressure, among others ( 16 ); however, the condition can also be asymptomatic ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of CYFRA21-1, AFP, CA-153, CEA, and CA-199 in the Diagnosis of Lung Cancer Ocular Metastasis in Hypertension Population

Tang

Huang

et al. 2021

Front. Cardiovasc. Med.

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Purpose: To detect lung metastases, we conducted a retrospective study to improve patient prognosis.Methods: Hypertension patients with ocular metastases (OM group; n = 58) and without metastases (NM group; n = 1,217) were selected from individuals with lung cancer admitted to our hospital from April 2005 to October 2019. The clinical characteristics were compared by Student's t-test and chi-square test. Independent risk factors were identified by binary logistic regression, and their diagnostic value evaluated by receiver operating characteristic curve analysis.Results: Age and sex did not differ significantly between OM and NM groups; There were significant differences in pathological type and treatment. Adenocarcinoma was the main pathological type in the OM group (67.24%), while squamous cell carcinoma was the largest proportion (46.43%) in the NM group, followed by adenocarcinoma (34.10%). The OM group were treated with chemotherapy (55.17%), while the NM group received both chemotherapy (39.93%) and surgical treatment (37.06%). Significant differences were detected in the concentrations of cancer antigen (CA)−125, CA-199, CA-153, alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), cytokeratin fraction 21-1 (CYFRA21-1), total prostate-specific antigen, alkaline phosphatase, and hemoglobin (Student's t-test). Binary logistic regression analysis indicated that CA-199, CA-153, AFP, CEA, and CYRFA21-1 were independent risk factors for lung cancer metastasis. AFP (98.3%) and CEA (89.3%) exhibited the highest sensitivity and specificity, respectively, while CYRFA21-1 had the highest area under the ROC curve value (0.875), with sensitivity and specificity values of 77.6 and 87.0%, respectively. Hence, CYFRA21-1 had the best diagnostic value.

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