Laryngeal malignancies – epidemiological data and particularities of the cases diagnosed in Western Romania (October 2016–July 2020)

Sitaru, Adrian Mihail; Flondor, Daniela; Dinu, Ștefania; Horhat, Delia Ioana; Iftode, Oana Andrada; Poenaru, Mărioara; Balica, Nicolae Constantin; Baderca, Flavia; Georgescu, D.; Chioran, Doina; Sarău, Cristian Andrei

doi:10.47162/rjme.63.1.16

Cited by 3 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Locally advanced cancers, including T3-4 and N1-3 disease, are more difficult to treat and usually require combination therapies. Although these cancers are not candidates for laryngeal preservation surgery if surgically resectable, definitive radiation therapy in association with cisplatin chemotherapy remains an option to organ preservation surgery [ 14 ]. According to Dyckhoff et al [ 15 ], in advanced laryngeal cancer, organ preservation with primary conservative treatment is likely to result in a significantly worse outcome in terms of overall survival, and the patients should be informed about this.…”

Section: Discussionmentioning

confidence: 99%

Management of Locally Advanced Laryngeal Cancer—From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe

Cirstea

Berteșteanu

Scăunașu

et al. 2023

IJERPH

View full text Add to dashboard Cite

Laryngeal cancer is an important oncological entity in which prognosis depends on the establishment of appropriate preventive and diagnostic measures, especially in high-risk populations. We present a retrospective two-year study (January 2021 to December 2022) with 152 patients diagnosed with laryngeal cancer from a tertiary hospital in Romania. The average age of the patients was 62 years old for both sexes, with a range from 44 to 83 years. The most frequent symptom was dysphonia with or without dyspnea in 142 cases (93.42%), followed by dyspnea alone in nine patients (5.92%) and dysphagia in one case (0.66%). Surgical treatment in this study consisted of partial laryngectomy (CO2 laser transoral tumor ablation, supraglottic horizontal laryngectomy or hemilaryngectomy), or total laryngectomy. The main treatment was total laryngectomy (63%). For the eight patients with initial organ preservation treatment, the average time of recurrence was about two-and-a-half years. For the four patients who underwent a total circular pharyngo-laryngectomy, the upper digestive tract needed to be rebuilt with a salivary bypass tube or with a tubed myocutaneous flap from the major pectoralis muscle. One strong point is characteristic of the study group in gathering patients with advanced stages of laryngeal carcinoma candidates for salvage surgery and extended reconstruction methods. The development of new prevention protocols is mandatory in Eastern European countries.

show abstract

Section: Discussionmentioning

confidence: 99%

Management of Locally Advanced Laryngeal Cancer—From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe

Cirstea

Berteșteanu

Scăunașu

et al. 2023

IJERPH

View full text Add to dashboard Cite

show abstract

“…Oropharyngeal cancer (OPC) is a malignancy that affects the oral cavity and pharyngeal region [ 1 ]. In recent decades, research has revealed a significant association between human papillomavirus (HPV) infection and the development of oropharyngeal cancer [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Analysis from Western Romania Comparing the Treatment and Survivability of p16-Positive versus p16-Negative Oropharyngeal Cancer

Chioreanu,

Balica,

Mot

et al. 2024

Cancers

Self Cite

View full text Add to dashboard Cite

Background: Oropharyngeal cancer is a global health concern due to its multifaceted nature. Recent molecular studies have linked p16 overexpression, associated with the human papillomavirus, to oropharyngeal cancer and its prognostic implications. Materials and Methods: This retrospective study in Western Romania examined 60 patients, categorizing them based on p16 biomarker status: 28 were p16 positive, and 32 were p16 negative. Statistical tests, including Fisher’s exact and chi2, were used for analysis. Results: Patients with p16-positive oropharyngeal cancer exhibited a better prognosis (3-year survival, p = 0.0477; midtreatment, p = 0.0349) and reported lower alcohol (p = 0.0046) and tobacco (p < 0.0001) use. Conclusions: The study highlights the importance of p16 testing in oropharyngeal carcinoma diagnosis. It suggests modifying treatment approaches based on p16 status and underscores the differing prognoses associated with p16-positive and p16-negative cases.

show abstract

“…Sendo assim, os casos de tuberculose pulmonar são divididos em primários e secundários. A tuberculose primária, responsável por cerca de 5-10% dos casos, se desenvolve logo após a infecção; já a tuberculose secundária (90-95% dos casos), é decorrente da reativação do bacilo que já estava presente no pulmão, porém de forma controlada, ou latente (NITU et al, 2017). O espalhamento do bacilo pelo pulmão pode levar à pneumonia lobular obstrutiva, e pode se desenvolver para pneumonia caseosa, caracterizada pelas lesões típicas da tuberculose e fibrose, que podem comprometer toda a fisiologia do órgão (HUNTER, 2018).…”

Section: Lista De Siglasunclassified

O papel das vesículas extracelulares na ativação de células dendríticas humanas durante a infecção por Mycobacterium tuberculosis

Silva

View full text Add to dashboard Cite

Aos meus pais, Eliana e Altair, que em nenhum momento fizeram menos que o máximo para que todos meus sonhos fossem realizados. Que saibam que toda conquista em meu nome é uma extensão do que vocês viabilizaram com seu amor, trabalho e dedicação. Essa não é diferente de nenhuma outra.-A minha noiva, Lara, que com seu amor instigou e impulsionou a concretização das nossas realizações. Que, desde a sua chegada em minha vida, tem sido agente multiplicador de feitos e de felicidade.-A minha orientadora, Dra. Fabiani Gai Frantz, que, com sua colaboração intelectual, propiciou a todos alunos do LIME atmosfera amplamente voltada ao debate e desenvolvimento científico. Que a todo momento buscou nos fornecer o melhor ambiente e ferramentas de trabalho. Que sempre nos prestigiou com autonomia e liberdade para inovar e colaborar com outros grupos. E agradeço, acima de tudo, pelo altruísmo de priorizar a preocupação com o futuro de seus alunos.-As instituições de fomento CAPES e CNPq pelo aporte financeiro, que viabilizou a bolsa de estudo e subsidiou os experimentos deste trabalho.-Aos meus primeiros orientadores, Raphael Vasconcellos e Leandro Licursi de Oliveira, que, por depositarem confiança, me formaram.-A todos professores do programa de Imunologia Básica e Aplicada pelos momentos de aprendizado e pelo empenho em formar ótimos profissionais.-Ao meu grande amigo, Murilo Duarte, que nunca se absteve em dividir os meus fardos e tornou esta jornada muito mais leve. A quem eu tenho imensa gratidão por me receber como um de seus amigos.

show abstract

Laryngeal malignancies – epidemiological data and particularities of the cases diagnosed in Western Romania (October 2016–July 2020)

Cited by 3 publications

References 26 publications

Management of Locally Advanced Laryngeal Cancer—From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe

Management of Locally Advanced Laryngeal Cancer—From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe

A Retrospective Analysis from Western Romania Comparing the Treatment and Survivability of p16-Positive versus p16-Negative Oropharyngeal Cancer

O papel das vesículas extracelulares na ativação de células dendríticas humanas durante a infecção por Mycobacterium tuberculosis

Contact Info

Product

Resources

About