Laryngeal Lymphoma: The High and Low Grades of Rare Lymphoma Involvement Sites

Abstract

The larynx is an extremely rare site of involvement by lymphomatous disease. We present two cases of isolated laryngeal high-grade and another low-grade lymphoma, together with a literature review of laryngeal lymphoma management.

Primary Lymphoma of the Larynx: A Case Report and Literature Review

“…The mean age at diagnosis is 70 years, with a range from 4 to 81 years. Sex-ratio has been reported to be variable in different series [5] [6]. Our patient was a 52-year-old male.…”

“…In fact, both macroscopic and radiological appearances of a large laryngeal tumour with a supraglottic submucosal component should alert to the possibility of laryngeal lymphoma [5] [6].…”

Epidemiology and prognostic indicators in laryngeal lymphoma: A population‐based analysis

“…Lymphoma of the larynx is an exceedingly uncommon malignancy due to the fact that the larynx contains a relatively small amount of lymphoid tissue. 6 Given its low occurrence, few studies have been able to delineate the epidemiologic characteristics and prognostic factors that affect laryngeal lymphoma. This study is the first to utilize a national cancer database to derive clinical and pathologic information regarding laryngeal lymphoma.…”

“…Squamous cell carcinomas account for more than 95% of all laryngeal neoplasms; primary lymphoma of the larynx is unusual and accounts for less than 1% of laryngeal tumors . Classic presenting symptoms of laryngeal lymphoma include lymphadenopathy, dysphagia, hoarseness, and dyspnea, with systemic symptoms being less common . Most available data regarding the prognostic factors of primary laryngeal lymphoma come from individual case reports.…”

“…1,[3][4][5] Classic presenting symptoms of laryngeal lymphoma include lymphadenopathy, dysphagia, hoarseness, and dyspnea, with systemic symptoms being less common. 1,6 Most available data regarding the prognostic factors of primary laryngeal lymphoma come from individual case reports. Using the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute, this study includes the largest number of patients with primary laryngeal lymphoma to date.…”