Laryngeal granular cell tumors in children: A literature review

Mur, Taha; Pellegrini, William R.; Tracy, Lauren F.; Levi, Jessica R.

doi:10.1016/j.ijporl.2020.110193

Cited by 5 publications

(15 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Granular cell tumors are rare lesions of Schwann cell origin that may arise anywhere in the body and are often found in the head and neck region [ 4 , 5 ]. They are rarely found in children.…”

Section: Discussionmentioning

confidence: 99%

“…Granular cell tumors (GCTs) are rare neoplasms that most commonly affect the skin and subcutaneous tissue [1][2][3], with approximately half found in the head and neck region. While the tongue is commonly involved, only 6% to 10% of head and neck cases occur in the larynx [4]. The majority of GCTs are benign, while malignant GCTs are extremely rare and comprise less than 2% of cases [1].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…GCTs can affect any age group, but are most commonly present during the fourth to sixth decade of life [ 1 , 2 , 5 ] and may be more common in women [ 1 , 4 , 5 ]. They are rarely seen in children, with only 38 pediatric cases of laryngeal GCTs in the literature [ 4 ]. Laryngeal GCTs present similarly to other laryngeal lesions, with hoarseness, stridor, dysphagia, and occasional hemoptysis, and patients may be misdiagnosed with asthma or bronchitis [ 4 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…They are rarely seen in children, with only 38 pediatric cases of laryngeal GCTs in the literature [ 4 ]. Laryngeal GCTs present similarly to other laryngeal lesions, with hoarseness, stridor, dysphagia, and occasional hemoptysis, and patients may be misdiagnosed with asthma or bronchitis [ 4 , 8 ]. Here we present a case of a pediatric patient with longstanding hoarseness.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Granular Cell Tumor in a 13-Year-Old Girl

Fraser¹,

Anthony²

2021

Cureus

View full text Add to dashboard Cite

Granular cell tumors are rare benign soft-tissue lesions that most commonly occur in the head and neck. They usually present in adulthood and are rarely seen in children. Here we present a 13-year-old girl who experienced symptoms of hoarseness of voice for most of her childhood and was unsuccessfully treated for asthma, acid reflux, allergies, and bronchitis before direct visualization revealed what was initially thought to be a vocal cord cyst. Surgical excision and pathology revealed the unexpected diagnosis of a vocal cord granular cell tumor. The patient has had resolution of dysphonia and is undergoing voice therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Granular Cell Tumor in a 13-Year-Old Girl

Fraser¹,

Anthony²

2021

Cureus

View full text Add to dashboard Cite

show abstract

Características clínicas y patológicas del tumor de células granulares en cuerda vocal. Revisión de la literatura

San Millán-González,

Santos-Pérez,

Duque-Holguera

et al. 2024

ORL

View full text Add to dashboard Cite

Introducción y objetivo: El tumor de células granulares, conocido como tumor de Abrikossoff, es una rara neoplasia con un patrón histológico distintivo. Aunque generalmente benigno, su capacidad para volverse maligno y su afectación en diversos tejidos presenta desafíos en su diagnóstico y tratamiento. Por tanto, esta revisión bibliográfica tiene como objetivo abordar los aspectos clínicos, histológicos, moleculares y terapéuticos de este tumor cuando se localiza en las cuerdas vocales. Método: Para llevar a cabo esta revisión, se realizó una búsqueda bibliográfica en bases de datos médicas, sin restricciones de idioma, con un rango de fechas del 11 de octubre de 2022 al 10 de octubre de 2023. Se seleccionaron 12 artículos que incluyeron casos clínicos, series de casos y revisiones sistemáticas. Resultados: Tras la búsqueda, se obtuvieron 12 artículos relevantes que definen aspectos clínicos, histológicos e inmunohistoquímicos, así como enfoques de tratamiento. A pesar de la contribución de todas las fuentes, se ha dado prioridad a las investigaciones más recientes. Discusión: El tumor de células granulares es una neoplasia rara que puede afectar cualquier parte del cuerpo, pero es más común en la cabeza y el cuello, incluyendo las cuerdas vocales. Su presentación clínica varía, y puede volverse agresivo, con metástasis en algunos casos. El síntoma más común es la disfonía. La nomenclatura del tumor ha evolucionado con el tiempo, y la histología revela células grandes con citoplasma eosinofílico granular y expresión de marcadores inmunohistoquímicos específicos. Por lo tanto, el diagnóstico diferencial es esencial para evitar errores de diagnóstico. El tratamiento principal es la extirpación quirúrgica, a menudo a través de métodos endoscópicos con láser de dióxido de carbono. Además, el seguimiento postoperatorio es crucial para la evaluación de la voz y la detección de complicaciones. Conclusiones: En resumen, esta revisión destaca la rareza y heterogeneidad del tumor de células granulares en las cuerdas vocales. Se enfatiza la importancia del diagnóstico diferencial, la inmunohistoquímica y el seguimiento postoperatorio para garantizar un manejo efectivo en las consultas de otorrinolaringología y la mejora de la calidad de vida de los pacientes afectados.

show abstract

S-100 Immunohistochemical Positivity in Rhabdomyoma: An Underestimated Potential Diagnostic Pitfall in Routine Practice

et al. 2022

View full text Add to dashboard Cite

A 66-year-old man presented with a 2.8 cm lesion of the left vocal cord. On contrast-enhanced computed tomography scans, the tumor extended to the supraglottis, subglottis, paraglottic space and anterior commissure, causing partial obstruction of the laryngeal lumen. At another hospital, a fragmented incisional biopsy was diagnosed as a granular cell tumor, as to the S-100 immunohistochemical positivity. After excision, the tumor revealed to be an adult-type laryngeal rhabdomyoma. The typical cytoplasmic rod-like inclusions and cross striations were more evident in the second specimen. We confirmed the unusual S-100 immunohistochemical positivity (variable intensity, >90% of tumor cells). Muscle markers were not performed on the previous biopsy, resulting positive in our specimen (Desmin: strong, diffuse expression; Smooth Muscle Actin: strong staining in 10% of tumor cells). Melan-A, CD68, GFAP, pan-cytokeratins, CEA, calretinin and neurofilaments resulted negative. To our brief, systematic literature review, S-100 positivity (usually variable, often weak or patchy/focal) was globally found in 19/34 (56%) adult-type rhabdomyomas of the head and neck region. Especially on fragmented biopsy material, the differential diagnoses of laryngeal rhabdomyomas may include granular cell tumors, oncocytic tumors of the salivary glands or of different origin, and paragangliomas.

show abstract

Laryngeal granular cell tumors in children: A literature review

Cited by 5 publications

References 39 publications

Granular Cell Tumor in a 13-Year-Old Girl

Granular Cell Tumor in a 13-Year-Old Girl

Características clínicas y patológicas del tumor de células granulares en cuerda vocal. Revisión de la literatura

S-100 Immunohistochemical Positivity in Rhabdomyoma: An Underestimated Potential Diagnostic Pitfall in Routine Practice

Contact Info

Product

Resources

About