Laryngeal carcinoma ex-papilloma in a non-irradiated, non-smoking patient: a clinical record and review of the literature

Hasan, Suhel; Dutt, Sunil; Kini, Usha; Shariff, Shameem; Nalinesha, K. M.; Prasad, Devi

doi:10.1017/s0022215100131251

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…Malignant transformation in non-irradiated and non-smoking patients suffering from respiratory papillomas is a very rare event. Only 13 patients with recurrent papillomatosis who developed a broncho-pulmonary carcinoma are reported in the literature [18]. However, one of our patients with juvenile multiple RRP and bronchial spreading of papillomatosis developed a bronchiogenic carcinoma without any history of smoking.…”

Section: Classification Clinical Course and Malignancymentioning

confidence: 68%

Long-term results of surgical treatment for recurrent respiratory papillomatosis

Preuss

Klußmann

Jungehülsing

et al. 2007

Acta Oto-Laryngologica

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In all, 64 patients (33%) underwent a total of 137 operations using the CO2 laser; 130 patients (67%) underwent a total of 565 microlaryngeal operations by surgery with cold instruments. Five percent of the patients treated with conventional microlaryngeal surgery and none of the patients treated with laser surgery required tracheostomy (p<0.05). Postoperative glottic webs and scar formations were found in 6% of all patients after laser surgery and 20% after conventional surgery (p<0.05). The different methods of treatment did not affect the rate of recurrence (p=0.61) Malignant transformation or secondary airway carcinoma were observed in 4% of all patients.

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Section: Classification Clinical Course and Malignancymentioning

confidence: 68%

Long-term results of surgical treatment for recurrent respiratory papillomatosis

Preuss

Klußmann

Jungehülsing

et al. 2007

Acta Oto-Laryngologica

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“…All of eight HPV11 isolates from papillomas and laryngeal cancer were identical to the prototype in this region of the URR (data not shown). The involvement of other agents in both HPV-related and unrelated carcinogeneses is well documented, with radiotherapy and smoking the prime candidates in RRP (15). It is noteworthy that patient 27 had been a heavy smoker from the age of 10 years until his death at age 25 years and had received treatment with several chemotherapeutic agents (e.g., interferon, adenine arabinoside, and cimetidine) which are recognized as potential cofactors in the malignant progression of RRP lesions (13).…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus and host variables as predictors of clinical course in patients with juvenile-onset recurrent respiratory papillomatosis

et al. 1997

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This study provides the first systematic evaluation of papillomavirus type and viral mutation occurring during the course of juvenile-onset recurrent respiratory papillomatosis. One hundred ninety-nine consecutive papillomas excised from 47 children between 1981 and 1996 at The New Children's Hospital in Sydney, Australia, were tested for human papillomavirus (HPV) DNA by PCR. PCR products from the viral upstream regulatory region (URR) enhancer were sequenced, and variation was related to clinical variables. Forty-four of the 47 children had HPV-induced papillomas, with type 11 accounting for 24 (55%) and type 6 accounting for 19 (43%); one (2%) was positive for either type 6 or 11. Overall, 183 (98%) of the 186 samples with amplifiable DNA were HPV positive. There was no change in HPV type over time and no statistically significant association between HPV type and disease aggressiveness. One novel, large-scale URR duplication was identified in an HPV type 11 isolate in the last of a series of six papillomas examined and the first from the bronchus. However, the duplication was not found in HPV type 11 isolates from the associated pulmonary carcinoma and its metastases in other organs. Three of 14 URR point mutations coincided with transcription factor binding sites, but there were no obvious associations with clinical course. Chi-square and multiple linear regression analyses of clinicopathological variables revealed early age at diagnosis (less than 4 years) as an independent predictor of aggressive disease (P < 0.001). A bimodal distribution of the age at diagnosis was noted, with peaks at 2 and 11 years of age.

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“…The incidence of high-grade dysplasia for LP is between 10% and 17.6% [24–26]. The progression of LP with dysplasia with multiple recurrences to carcinoma was reported [10]. Hall et al [27] reported that only one (2%) of the 54 adult patients with recurrent respiratory papillomatosis developed SCC.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature

El‐Achkar

Duarte

Saggioro

et al. 2018

Case Reports in Otolaryngology

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Background The malignant transformation of laryngeal papillomatosis (LP) into squamous cell carcinoma (SCC) can occur in up to 4% of LP cases. The low-risk HPV types 6 and 11 are those that are most commonly related to LP; however, high-risk HPV types may be present. The present study reviews the literature on cases of malignant transformation of LP in adults and reports a clinical case. Case Report A 47-year-old male patient exhibiting hoarseness for 4 months presented an exophytic lesion in the right palatine tonsil and a digitiform-like lesion in the right vocal fold. The biopsy revealed a well-differentiated SCC in the vocal cord, which showed a transition zone with a squamous papillomatous lesion. By using the chromogenic in situ hybridization (CISH) test, both lesions showed a positive result for high-risk HPV types 16 and 18 and negative for low-risk HPV types 6 and 11. The final diagnosis was SCC arising from LP. The patient underwent surgical treatment. After 36 months of follow-up, no signs of recurrence were observed. Results The literature review revealed 25 cases of malignant transformation into SCC of LP with adult onset. Of these, only 9 cases were assessed by CISH and/or PCR for HPV identification, of which 7 were positive. The current study focuses on the eighth case, suggesting the involvement of the high-risk HPV types in its pathogenesis. Conclusions LP is considered a benign lesion with the potential for malignant transformation, which reinforces the need for its early diagnosis and the constant monitoring of patients with LP.

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Laryngeal carcinoma ex-papilloma in a non-irradiated, non-smoking patient: a clinical record and review of the literature

Cited by 7 publications

References 25 publications

Long-term results of surgical treatment for recurrent respiratory papillomatosis

Long-term results of surgical treatment for recurrent respiratory papillomatosis

Human papillomavirus and host variables as predictors of clinical course in patients with juvenile-onset recurrent respiratory papillomatosis

Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature

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