Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA

Lu, Baocai; Li, Jing; Gao, Qingzu; Yu, Wenfa; Yang, Qin; Li, Xiaoyü

doi:10.1016/j.gene.2014.02.043

Cited by 57 publications

(49 citation statements)

References 18 publications

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“…65 Furthermore, in a case-control study focused on laryngeal cancer, ERCC1 rs11615 and ERCC5 rs17655 polymorphisms were associated with increased risk of developing laryngeal cancer. 66 Vaccinia-related kinase-1 (VRK1) protein VRK1 protein belongs to a family of 3 protein kinases implicated in regulation of cell proliferation by phosphorylation of p53 and cooperation with c-Jun and ATF2. VRK1 expression is activated by E2F and inhibited by p16 and Rb.…”

Section: Dna Damage Repair Biomarkersmentioning

confidence: 99%

A genetic view of laryngeal cancer heterogeneity

2016

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During the recent decades significant improvements in the understanding of laryngeal molecular biology allowed a better characterization of the tumor. However, despite increased molecular knowledge and clinical efforts, survival of patients with laryngeal cancer remains the same as 30 years ago. Although this result may not make major conclusions as preservation approaches were not broadly used until the time of database collection, it seems to be clear that there is still window for improvement.

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Section: Dna Damage Repair Biomarkersmentioning

confidence: 99%

A genetic view of laryngeal cancer heterogeneity

2016

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“…Many previous epidemiologic studies have been conducted to examine the association between ERCC2 and ERCC3 gene polymorphisms and risk of cancers, such as lung, endometrial, head and neck, and laryngeal cancer (Hu et al, 2006;Doherty et al, 2011;Sakoda et al, 2012;Khlifi et al, 2014;Lu et al, 2014). Hu et al (2006) conducted a case-control study in a Chinese population, and found that ERCC2 and ERCC3 gene polymorphisms contribute to the development of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Khlifi et al (2014) investigated the role of ERCC2 and ERCC3 gene polymorphisms on susceptibility to head and neck cancer, and they observed no statistically significant association between the risk of head and neck cancers and the two gene polymorphisms. Lu et al (2014) conducted a case-control study in a Chinese population, and suggested that ERCC2 and ERCC3 polymorphisms contribute to the development of laryngeal cancer. Only one study reported an association between ERCC2 and ERCC3 gene polymorphisms and the development of osteosarcoma (Jin et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Role of ERCC2 and ERCC3 gene polymorphisms in the development of osteosarcoma

Ma¹,

Zhang²,

Ts³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the role of common SNPs in ERCC2 (rs13181 and rs1799793) and ERCC3 (rs4150441 and rs4150506) in the development of osteosarcoma. A 1:2 matched case-control study was conducted. Between January 2012 and December 2013, 141 patients with pathologically diagnosed osteosarcoma and 282 controls were recruited in our study. Genotyping of ERCC2 rs13181 and rs1799793 as well as ERCC3 rs4150441 and rs4150506 were performed using polymerase chain reaction coupled with restriction fragment length polymorphism. The genotype distributions of ERCC2 rs13181 and rs1799793 as well as ERCC3 rs4150441 and rs4150506 showed no significant difference between patients with osteosarcoma and controls, as analyzed by c 2 tests. Multivariate logistic regression analysis did not reveal significant associations between ERCC2 rs13181/rs1799793 or ERCC3 rs4150441/ rs4150506 gene polymorphisms and the development of osteosarcoma in codominant, dominant, and recessive models. In conclusion, we did not find any association between ERCC2 or ERCC3 gene polymorphisms and the development of osteosarcoma. Future studies with larger sample sizes may contribute in elucidating the impact of ERCC2 and ERCC3 gene polymorphisms on osteosarcoma risks.

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“…The XPG belongs to NER, and this gene has a function of extreme UV-sensitivity and a high genetic predisposition to sunlight-caused cancers (Cordonnier and Fuchs, 1999). Previous studies have shown that XPG gene polymorphisms are associated with development of several kinds of cancers, such as digestive system cancer, head and neck cancer, colorectal cancer, prostate cancer, laryngeal cancer, and bladder cancer (Du et al, 2014;Lu et al, 2014;Mirecka et al, 2014;Jiang et al, 2015;Yu et al, 2015). In particular, there are a few studies reporting on the association between XPG gene polymorphisms and the development of breast cancer, but the results are inconclusive (Kumar et al, 2003;Mechanic et al, 2006;Crew et al, 2007;Ding et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population

Sun

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of XPG rs2094258, rs751402, and rs17655 was performed using polymerase chain reaction-restriction fragment length polymorphism. Using the chisquare test, we did not find any significant differences in the genotype distributions of XPG rs2094258 (χ 2 = 1.48, P = 0.48), rs751402 (χ 2 = 0.65, P = 0.72), and rs17655 (χ 2 = 0.01, P = 0.92) genes between breast cancer patients and control subjects. The genotype distributions of XPG rs2094258, rs751402, and rs17655 did not deviate from the HardyWeinberg equilibrium in control subjects, and the P values were 0.58, 0.97, and 0.26, respectively. Using unconditional logistic regression analysis, we found that XPG rs2094258, rs751402 and rs17655 gene polymorphisms are not associated with the development of breast cancer after adjusting for potential confounding factors. In conclusion, we found that XPG rs2094258, rs751402, and rs17655 do not influence the development of breast cancer in a Chinese population.

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Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA

Cited by 57 publications

References 18 publications

A genetic view of laryngeal cancer heterogeneity

A genetic view of laryngeal cancer heterogeneity

Role of ERCC2 and ERCC3 gene polymorphisms in the development of osteosarcoma

Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population

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