Laryngeal cancer in Lower Silesia: descriptive analysis of 501 cases

Kręcicki, Tomasz; Zalesska−Kręcicka, Maria; Jagas, Maria; Szajowski, Krzysztof; Rak, Józef

doi:10.1016/s1368-8375(98)00040-2

Cited by 19 publications

(17 citation statements)

References 17 publications

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“…Cancer of the larynx is the sole tumor of the head and neck area with absolute male dominance both in our country and in others. For example, in Turkey women constitute only 8.7% of laryngeal carcinoma patients [17], in Finland 5% (this figure having remained constant over the last 30 years) [19], and in Poland the ratio of men to women is 8.5/1 [16].…”

Section: Discussionmentioning

confidence: 99%

How often is total laryngectomy necessary for the treatment of T1 failures after radiotherapy or cordectomy?

Markou

Nikolaou

Nalbadian

et al. 2002

European Archives of Oto-Rhino-Laryngology

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Between 1992 and 1998, 547 patients (pts) with laryngeal SCC were diagnosed and treated in our department, 145 (27%) of whom presented with glottic tumors T1N0M0 (125 T1a and 20 T1b). Seventy-eight (54%) were treated surgically with cordectomy and 67 (46%) with radiotherapy. After a median follow-up time of 43 months, 22 (15.2%) of the 145 pts presented with recurrent disease. In more detail, 16 (13%) of the 125 T1a pts and 6 (30%) of the 20 T1b pts had recurrences. Among the 78 surgically treated patients only 4 (5%) had recurrence, while 18 (27%) of the radiotherapy group relapsed. The difference is statistically significant (log rank test, P = 0.0001 < 0.05). After salvage treatment, of the 67 pts of the radiotherapy group 57 (85%) remain disease-free, 49 (73%) retaining their larynx intact and 1 only having undergone cordectomy. Among the cordectomy group 75 (96%) pts remain disease-free with only 1 having had a total laryngectomy. Using the Kaplan-Meier method and calculating the disease-free survival regardless of salvage treatment, there is no doubt that surgical treatment statistically is more successful than radiotherapy (log rank test, P = 0.01 < 0.05). Analysis of parameters such as tumor differentiation and T1a or T1b staging, which indeed influence the overall recurrence rate, did not alter the favorable outcome after surgical treatment.

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Section: Discussionmentioning

confidence: 99%

How often is total laryngectomy necessary for the treatment of T1 failures after radiotherapy or cordectomy?

Markou

Nikolaou

Nalbadian

et al. 2002

European Archives of Oto-Rhino-Laryngology

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“…The highest incidence of this malignancy is observed in the fifth and sixth decades of life (3) and it represents 10% of malignancies in men and 4% in women worldwide. Despite recent improvements in diagnostic and therapeutic techniques, there has been no improvement in the 5-year survival rates for laryngeal cancer patients over the last 30 years (4).…”

Section: Introductionmentioning

confidence: 99%

Expression of angiogenic growth factors in laryngeal carcinoma

Korampalli

Stafford

2013

Molecular and Clinical Oncology

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Abstract. Over 2,200 cases of carcinoma of the larynx are diagnosed in the UK annually, with an overall 5-year survival rate of 67%. Angiogenesis is vital for the growth and metastasis of solid tumours and the expression of key angiogenesis-related proteins has been shown to be of prognostic significance. In this study we reported the expression of key angiogenesis-related factors, selected from a pilot array study, in a cohort of laryngeal tumours and associated metastatic lymph nodes. Forty patients diagnosed with squamous cell carcinoma of the larynx were recruited. Tissue specimens were obtained intra-operatively, prior to chemo-and/or radiotherapy, from the tumours and secondary lymph nodes. The patient group comprised 32 men and 8 women with a mean age of 68 years (range, 51-89 years). The relative expression of the angiogenesis-related proteins angiogenin, interleukin (IL)-8, tissue inhibitor of metalloproteinases-1 (TIMP-1), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)-basic and insulin-like growth factor binding protein 3 (IGFBP3) was determined in the tissue lysates by ELISA. The expression of angiogenin was higher in early-stage compared with late-stage tumours (P=0.034) and the expression of IGFBP3 was higher in tumours compared with the metastatic lymph nodes (P=0.016). No statistically significant differences were recorded for VEGF, FGF, TIMP-1 or IL-8 between tumour stages or primary tumours and lymph nodes. To the best of our knowledge, this study was the first to investigate multiple angiogenic factors in the lysates of laryngeal carcinomas and metastatic nodes and identified angiogenin and IGFBP3 as factors possibly involved in tumour progression. A greater understanding of their function may offer novel prognostic and/or therapeutic options.

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“…Its incidence varies widely in different countries, and increasing trends have been observed in many previous studies. 1,2 Prognosis is based on commonly recognized prognostic factors, including stage, site of the primary tumor and histopathologic grade. In recent years, attention has been focused on genetic alterations of several protooncogenes and tumor suppressor genes that mediate signal transduction pathways involved in cell proliferation and differentiation and cell cycle control.…”

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confidence: 99%