Laryngeal Applications of Platelet Rich Plasma and Platelet Poor Plasma: A Systematic Review

Suresh, Aishwarya; Balouch, Bailey; Martha, Vishnu; Sataloff, Robert T.

doi:10.1016/j.jvoice.2021.07.007

Cited by 17 publications

(16 citation statements)

References 26 publications

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“…The injection of platelet-rich plasma into injured tissues is an old approach used in orthopedic, plastic surgery, dermatology, or rehabilitation [ 17 ]. In otolaryngology, PRP was used in the management of neck fistula [ 18 ], vocal fold scars [ 19 ], or tympanic membrane perforation [ 20 ], reporting encouraging results.…”

Section: Discussionmentioning

confidence: 99%

Platelet-rich plasma injection in the olfactory clefts of COVID-19 patients with long-term olfactory dysfunction

Lechien

Bon

Saussez

2022

Eur Arch Otorhinolaryngol

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Objective To investigate safety, feasibility, and effectiveness of platelet-rich plasma (PRP) injection into the olfactory clefts of COVID-19 patients with persistent olfactory dysfunction (OD). Methods From March 2022 to July 2022, COVID-19 patients with persistent OD were consecutively recruited to benefit from PRP injection into the olfactory clefts. Patient pain, annoyance, time of procedure, and adverse events were evaluated. Olfactory function was evaluated at baseline and 2-month post-injection with the olfactory disorder questionnaire (ODQ) and threshold, discrimination, and identification (TDI) test. Results Eighty-seven patients with anosmia ( N = 30), hyposmia ( N = 40), or parosmia ( N = 17) with a mean OD duration of 15.7 months completed the evaluations. The PRP injection was successfully performed in all patients with a mean procedure time of 18.4 ± 3.4 min. The adverse events included transient epistaxis ( N = 31), parosmia related to xylocaine spray ( N = 10), and vasovagal episode ( N = 2). The injection procedure was evaluated as somewhat or moderately painful by 41 (47%) and 22 (25%) patients, respectively. Thirty-seven patients were assessed after 2 months post-injection. The mean ODQ and TDI scores significantly improved from baseline to 2-month post-injection ( p < 0.01). The olfactory improvement occurred after a mean of 3.6 ± 1.9 weeks. Conclusion The injection of PRP into the olfactory clefts is safe and associated with adequate patient-reported outcomes. The findings of this preliminary study suggest possible efficacy on subjective and psychophysical evaluations, but future randomized controlled studies are needed to determine the superiority of PRP injection over placebo.

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Section: Discussionmentioning

confidence: 99%

Platelet-rich plasma injection in the olfactory clefts of COVID-19 patients with long-term olfactory dysfunction

Lechien

Bon

Saussez

2022

Eur Arch Otorhinolaryngol

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“…She benefited from 2 doses of vaccine. There was no abnormality in the nasofibroscopic examination and the olfactory cleft endoscopic scale score was 0 9 . The threshold, discrimination, and identification scores were 1, 8, and 0, respectively.…”

Section: Resultsmentioning

confidence: 90%

Injection of Platelet Rich Plasma in the Olfactory Cleft for COVID-19 Patients With Persistent Olfactory Dysfunction: Description of the Technique

Lechien

Saussez

2022

Ear Nose Throat J

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In this paper, we described technique of platelet rich plasma injection into the olfactory cleft in a 22-year-old female with 24-month post–COVID-19 anosmia. The technique starts with the blood extraction and the isolation of PRP through a 10-min centrifugation. The supernatant was injected in nasal regions after a local anesthesia through a 0° rigid optic. Several points of .2–.5 mL were performed in the nasal septum in regard of the head of the middle turbine and in the head of the middle turbine in both sides. The baseline threshold, discrimination, and identification scores were 1, 8, and 0, and the Olfactory Disorder Questionnaire score was 51, respectively. The injection of PRP in olfactory cleft was done without complication and mild pain. The patient perception of recovery of smell sense occurred at 3-week post-injection. From this time, the smell sense progressively improved to the 2-month consultation. At 2-month post-injection, the TDI scores reached 16, 16, and 16 (48), while the Olfactory Disorder Questionnaire was 73. The injection of PRP into the olfactory cleft appears to be a safe and easiness new approach that may improve the recovery of smell sense. Future controlled studies are needed.

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“…The platelet rich plasma is an old technique used in orthopedic, dermatology, plastic surgery or rehabilitation to regenerate the injured tissues. In otolaryngology, PRP was used in the management of vocal fold scars [11], tympanic membrane perforation [12], or neck fistula [13], with encouraging results. The first use in olfaction was made in a preliminary case-series by Carol Yan in 2019 [13], while another study is in process in Brussels (not yet published) [15].…”

Section: Discussionmentioning

confidence: 99%

Injection of Platelet Rich Plasma in the Olfactory Cleft for COVID-19 Patients with Persistent Olfactory Dysfunction: Description of the Technique

Lechien¹,

Saussez²

2022

Preprint

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Objective: To describe technique of platelet rich plasma injection into the olfactory cleft in patients with long-term COVID-19 olfactory dysfunction. Methods: The technique starts with the blood extraction and the isolation of PRP through a 10-min centrifugation (4,200 rpm). The supernatant was injected in nasal regions with a 27-G needle after a local anesthesia with Xylocain 10% spray. The injection was performed through a 0° rigid optic. Precisely, several points of 0.2–0.5 mL were performed in the nasal septum in regard of the head of the middle turbine, and in the head of the middle turbine in both sides. Clinical, psychophysical and pain outcomes were evaluated pre- to post-injection. Results: A 22-year-old female with 24-month post-COVID-19 anosmia was recruited for the injection of PRP. The olfactory cleft endoscopic scale score was 0 and the threshold, discrimination and identification scores were 1, 8 and 0, respectively. The Olfactory Disorder Questionnaire score was 51. The patient benefited from the injection of 2.2 mL of PRP in nasal regions, which was done without complication. The procedure pain level was 2/10, while the local anesthesia with xylocaine 10% was judged as the most annoyance step with a score of 3/10. At 2-month post-injection, the TDI scores reached 16, 16, and 16 (48), while the Olfactory Disorder Questionnaire was 73. The patient described its recovery as very rapid, lasting 3-4 days, and occurring 3-week post-injection. Conclusion: The injection of PRP into the olfactory cleft is a safe and easiness new approach that may improve the recovery of smell sense.

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Laryngeal Applications of Platelet Rich Plasma and Platelet Poor Plasma: A Systematic Review

Cited by 17 publications

References 26 publications

Platelet-rich plasma injection in the olfactory clefts of COVID-19 patients with long-term olfactory dysfunction

Platelet-rich plasma injection in the olfactory clefts of COVID-19 patients with long-term olfactory dysfunction

Injection of Platelet Rich Plasma in the Olfactory Cleft for COVID-19 Patients With Persistent Olfactory Dysfunction: Description of the Technique

Injection of Platelet Rich Plasma in the Olfactory Cleft for COVID-19 Patients with Persistent Olfactory Dysfunction: Description of the Technique

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