Laryngeal and Velopharyngeal Sensory Impairment in Obstructive Sleep Apnea

Nguyen, Anh Tu Duy; Jobin, Vincent; Payne, Richard J.; Beauregard, Josée; Naor, Naftaly; Kimoff, R. John

doi:10.1093/sleep/28.5.585

Cited by 143 publications

(117 citation statements)

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“…Several studies have supported this hypothesis by confirming upper airway neuropathy in OSAS patients [3][4][5]. Other research groups have also supported the hypothesis with contributing data [6][7][8]. In these studies, various methods for measuring local sensory neuropathy have been used, such as vibration [6], 2-point discrimination [7], and air-pressure pulses [8].…”

Section: Introductionmentioning

confidence: 83%

“…Other research groups have also supported the hypothesis with contributing data [6][7][8]. In these studies, various methods for measuring local sensory neuropathy have been used, such as vibration [6], 2-point discrimination [7], and air-pressure pulses [8]. However, no attempts have been made to correlate the degree of sensory deficit in the soft palate with the duration of snoring.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of change in palatal sensation in obstructive sleep apnea patients by using two-point palatal discrimination

Choi

Kim

2017

Sleep Medicine

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Section: Introductionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Assessment of change in palatal sensation in obstructive sleep apnea patients by using two-point palatal discrimination

Choi

Kim

2017

Sleep Medicine

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“…Changes in sensation, muscle structure, and physiological properties of UA have been reported in patients with OSAS; these changes are referred to as airway remodeling. But whereas the structural and functional properties of muscles of OSAS patients have been extensively analyzed [5,[12][13][14], the motor nerve fibers and motor endplates as well as the potential role of sensory nerve impairment in OSAS have not been sufficiently investigated [15,16]. Furthermore, the available data are heterogeneous and sometimes contradictory, because of the heterogeneity of the UA muscles, the different nerves innervating these muscles and the UA mucosae, and the differences in the methods used.…”

Section: The Neurological Theory Of Osas and The Upper Airways Remodementioning

confidence: 99%

Nerve and Muscle Changes in the Upper Airways of Subjects with Obstructive Sleep Apnea: Structural Basis for the Neurogenic Theory

Cobo¹,

Macías²,

Alvarez³

et al. 2017

Sleep Apnea - Recent Updates

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Obstructive sleep apnea syndrome (OSAS) is a widely diffused disease associated with specific genetics, age, gender, craniofacial and upper airways anatomy, obesity, and endocrine conditions, but not with ethnicity profiles. The so-called neurogenic neurogenic theory of OSAS postulates that the collapse of the upper airways that characterize this disease is due to peripheral nerve degeneration that leads to muscle atrophy and collapse. This review attempts to summarize the structural and functional changes in both the sensory and motor innervation of the walls of the upper air ways in patients suffering from OSAS.

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“…[3][4][5] In these studies, several different methods of measuring local sensory neuropathy have been used, such as two-point discrimination, 4) vibration, 5) and air-pressure pulses 5) ; however, there were no attempts to evaluate the gustatory function in the SDB patients. In the studies about SDB, the gustatory dysfunction has been focused on as a side effect after surgical…”

mentioning

confidence: 99%

Evaluation of Gustatory Function in Patients with Sleep Disordered Breathing

Ahn¹,

Bae²,

Yoon³

et al. 2014

Journal of Oral Medicine and Pain

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Purpose: The aim of this study is to evaluate the difference between gustatory functions in a sleep disordered breathing (SDB) group and a control group. The pathogenesis of SDB has not been fully understood. Though the precise contributions of neuromuscular and anatomical factors on SDB pathogenesis are still debated, we hypothesized that the gustatory dysfunction could be predisposed to SDB.Methods: All patients were diagnosed as SDB by polysomnography (PSG). On the basis of PSG results, patients were divided into 3 groups: snoring, mixed, and obstructive sleep apnea (OSA). The control group comprised healthy volunteers who were the same age as those of the SDB group and whose breathing was verified as normal using a portable sleep monitor device. The patient group and the control group were evaluated for gustatory functions with an electrogustometry (EGM). The electrical taste thresholds were measured in the anterior, midlateral, and posterior sides of the tongue and soft palatal regions, both sides. To find out the difference in EGM scores, statistical analysis was performed using the Kruskal-wallis and Mann-Whitney U test with 95% confidence interval and p<0.05 significance level. Results:The patients with SDB had higher EGM scores than the control group at all spots tested, except for the right midlateral of the tongue, and there was a statistical significance in the comparison between the control group and the divided SDB groups, respectively. Among the divided SDB groups, the snoring group had the most significant differences in the number of the measured spots, but there was no difference among the snoring, mixed, and OSA groups. Conclusions:These results may suggest that neurologic alterations with sleep disordered breathing could be associated with gustatory dysfunction. In the future, further systemic studies will be needed to confirm this study.

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Laryngeal and Velopharyngeal Sensory Impairment in Obstructive Sleep Apnea

Abstract: Mucosal sensory function is impaired at multiple upper-airway sites in OSA.

Cited by 143 publications

References 0 publications

Assessment of change in palatal sensation in obstructive sleep apnea patients by using two-point palatal discrimination

Assessment of change in palatal sensation in obstructive sleep apnea patients by using two-point palatal discrimination

Nerve and Muscle Changes in the Upper Airways of Subjects with Obstructive Sleep Apnea: Structural Basis for the Neurogenic Theory

Evaluation of Gustatory Function in Patients with Sleep Disordered Breathing

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