Laryngeal and Ear Involvement in Rheumatoid Arthritis in North India

“…The hallmark characteristic of the disease is the potential of the synovial inflammation to cause cartilage damage, bone erosions and subsequent changes in joint integrity [3]. RA has the potential to affect the form and function of many otolaryngological joints, such as the ossicular joints located in the ear, the temporomandibular joint, and the cricoarytenoid joints [4][5][6]. The incudomalleolar and incudostapedial joints of the middle ear are freely movable joints called diathroses.…”

Section: Introductionmentioning

confidence: 99%

Peripheral and Central Auditory Manifestation of Rheumatoid Arthritis

Munjal¹

2017

GJO

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The present study was conducted with the aim to investigate the peripheral and central auditory manifestations in individuals with RA. 40 subjects (age range: 25-45 years), diagnosed with RA and 40 age and sex matched otologically normal subjects participated in the study. Participants underwent a comprehensive audiological test battery comprising of conventional and extended high frequency puretone audiometry, impedance audiometry, otoacoustic emissions (OAEs) and auditory brainstem responses (ABR). Significant difference between the puretone thresholds for the two groups was found at high frequencies (beyond 4 kHz). Majority of the subjects in RA group had absent/reduced amplitude for TEOAE. A highly statistically significant difference was observed between the RA and the control group for the absolute latency of wave I, III and V of the left ear. Considering the high incidence of hearing loss in RA group, a regular referral for audiological evaluations is suggested.

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Soluble adenylyl cyclase in the eye

Lee

Marmorstein

2014

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Adenylyl cyclases (AC) are a family of enzymes which convert ATP to cAMP an essential intermediate in many signal transduction pathways. Of the 10 AC genes in man, 9 fall into the category of transmembrane ACs (tmAC), which associate with G-protein coupled receptors (GPCRs) and are activated by forskolin. The 10th AC, termed soluble AC (sAC) is neither activated by forskolin nor does it interact with GPCRs. Rather, sAC can be found in many compartments within the cell and is activated by bicarbonate. As such, sAC is considered a major sensor of bicarbonate in many tissues. The pathways involving sAC vary in different tissues and organ systems, and are as diverse as facilitating sperm capacitation and regulating pressure in the eye. The role of sAC in the eye has only recently begun to receive significant attention. Here we summarize what is known about the roles of sAC in the eye.

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Laryngeal and Ear Involvement in Rheumatoid Arthritis in North India

Cited by 3 publications

References 0 publications

Videolaryngostroboscopy and voice evaluation in patients with rheumatoid arthritis

Videolaryngostroboscopy and voice evaluation in patients with rheumatoid arthritis

Peripheral and Central Auditory Manifestation of Rheumatoid Arthritis

Soluble adenylyl cyclase in the eye

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