Laryngeal amyloidosis with laryngocele

Aydın, Ömer; Üstündağ, Emre; İşeri, Mete; Özkarakaş, Haluk; Oguz, Ali Kemal

doi:10.1017/s0022215100143981

Cited by 26 publications

(24 citation statements)

References 17 publications

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“…Localization of the lesion in the larynx is to the ventricle, vestibular folds, vocal folds, epiglottis, aryepiglottic folds, and subglottis in order of frequency [7]. Hoarseness is the most common symptom, progressive dyspnoea; haemoptysis and dysphagia are other presenting symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Laryngo-tracheobronchial Amyloidosis: a Case Report and Review of Literature

Wang

Yang

Chen

et al. 2014

Chinese Medical Sciences Journal

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Amyloidosis is a spectrum of diseases characterized by abnormal extracellular accumulation of proteinaceous material; its precise etiology still remains unclear. It may affect multiple organs, of which the commonest sites are larynx, bronchus and kidney. Laryngeal amyloidosis is usually a localized phenomenon rarely associated with systemic involvement, here we report a case of laryngeal amyloidosis with tracheobronchial involved. The patient was 31-years old. He had a history of open surgical operation for laryngeal amyloidosis in the left ventricle 4-years ago. This time he was suffered by amyloid deposition in his right ventricle, the lesion was excised on staged laryngoscopy under general anesthesia. After 20-months follow-up, the post-operative recovery was wonderful. The bronchoscopy examination and computerized tomography scan for chest demonstrated he also had right main bronchus amyloidosis. Being of no dyspnea, he was unwilling to accept an operation on bronchus. Though amyloidosis is a benign lesion, up to date, there are no curable treatments for such a disease, for severe cases, it may be fatal as a result of airway obstruction or respiratory failure. Here we review the pertinent references on this subject, and discuss the main managements for amyloidosis on larynx and bronchus.

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Section: Discussionmentioning

confidence: 99%

“…The male to female ratio is 3:1 and the ages ranging from 11-80 years, but the maximum incidence lies in the fifth decades [7].…”

Section: Discussionmentioning

confidence: 99%

Laryngo-tracheobronchial Amyloidosis: a Case Report and Review of Literature

Wang

Yang

Chen

et al. 2014

Chinese Medical Sciences Journal

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“…Acquired factors that raises intraglottic pressure associated in causation of laryngocoele such as performing Valsalva manoeuvre 16 , playing wind instruments, glass blowing 4,5,7 ventricular phonation during speech 2 , laryngeal papillomatosis in children 7 . Association of laryngocoele with other diseases such as amyloidosis 17 , ankylosing spondylosis 5 , and oncocytic cysts 18 have been reported. Laryngocoele are usually asymptomatic 5 , may present with dysphonia 11 , neck swelling 6,15,16 sore throat, cough, dyspnoea, stridor, foreign body sensation, airway obstruction 8,15 rarely.…”

Section: Discussionmentioning

confidence: 99%

“…However, X-ray neck in anteroposterior and lateral view especially with Valsalva manoeuvre are helpful. CT scan has proved to be most accurate in defining its extent, type, differentiating it from cystic formation and identifying co existing laryngeal cancer and other disease 6,11,13,15,17,19 . MRI is also useful.…”

Section: Discussionmentioning

confidence: 99%

Mixed laryngocoele: A rare cause for acute airway obstruction

Patil

Karadi

et al. 2013

Int J of Biomed & Adv Res

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“…[6] In large lesions, laryngofissure, supraglottic laryngectomy or total laryngectomy may be required. [14] Spontaneous regression of amyloidosis of larynx has been also reported. [15] Regular follow-up with periodic laryngeal and nasopharyngeal examination and imaging studies is required to detect recurrence at an early stage.…”

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confidence: 99%

Nasopharyngeal and laryngeal amyloidosis: a case report

Yurttaş¹

2014

J Med Updates

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Amyloidosis is a clinical disorder caused by extracellular proteinaceous deposits of insoluble abnormal group of fibrils with characteristic microscopic, histochemical, and ultrastructural features. Amyloid is an extracellular amorphous eosinophilic protein, which displays apple-green birefringence with polarized light when stained with Congo red or shows metachromasia with crystal violet or methyl violet dyes. [1][2][3][4] Systemic and localized forms are the main clinical categories of the amyloidosis. Systemic amyloidosis can manifest as immunoglobulin light chain derivative (AL) amyloidosis, which is associated with primary systemic amyloidosis, multiple myeloma, or plasma cell dyscrasias. Amyloid associated (AA) amyloid occurs in patients with chronic inflammatory conditions or neoplastic disease. Familial amyloidosis is a rare manifestation of systemic amyloidosis which accounts for less than 2% of the cases.[5] In humans, more than 20 different, unrelated proteins are known to form amyloid fibrils. ÖzetK›rk dokuz yafl›ndaki kad›n hasta 4 y›ldan beri ilerleyen k›s›k ses, bo¤az›n›n arka taraf›nda yabanc› cisim hissi, kulak a¤r›s›, ses k›s›kl›¤› ve a¤›zdan soluma yak›nmalar›yla klini¤imize kabul edildi. Nazolarengoskopi orofarenkse do¤ru uzanan bir sa¤ nazofarengeal kitleyi gös-termekteydi. ‹ndirekt larengoskopi sa¤ ventrikül band›ndan kaynaklanan ve sa¤ vokal kordun üzerine do¤ru uzanan bir granülomatöz kitleyi ortaya ç›kard›. Granülomatöz kitle normal larenks mobilitesini bozmuyordu. Yutma zorlu¤u öyküsü yoktu. Kontrastl› bilgisayarl› tomografi nazofarenks ve glotisi tutan düzgün yüzeyli bir kitlenin var oldu¤unu gösterdi. Lezyonun eksizyonel biyopsisi için direkt larengoskopi planland›. Histopatolojik inceleme nazofarenks ve larenks amiloidozunu ortaya ç›kard›. ‹leri de¤erlendirmelerde sistemik amiloidoz saptanmad›. Bu olgu sunumunun amac› son derecede seyrek görülen izole primer nazofarenks ve larenks amiloidozu olgusunu sunmak ve güncel literatür bilgilerini kullanarak tart›flmakt›r.Anahtar sözcükler: Primer amiloidoz, nazofarenks, larenks. AbstractA 49-year-old woman admitted to our clinic due to a progressive hoarse voice for 4 years, foreign body sensation in the back of her throat, otalgia, hoarseness and mouth breathing. Nasolaryngoscopy demonstrated a right nasopharyngeal mass extending to oropharynx. Indirect laryngoscopy revealed a granulomatous lesion originating from right band ventricle and extending on the right vocal fold. The granulomatous lesion did not alter correct laryngeal mobility. There was no history of difficulty in swallowing. A contrast enhanced computed tomography showed a smooth mass involving nasopharynx and glottis. A direct laryngoscopy was planned for excisional biopsy of the lesion. Histopathological examination revealed nasopharyngeal and laryngeal amyloidosis. Further evaluations were negative for systemic amyloidosis. The aim of the report is to present an extremely rare case of isolated primary nasopharyngeal and laryngeal amyloidosis and discuss by using current lite...

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Laryngeal amyloidosis with laryngocele

Cited by 26 publications

References 17 publications

Laryngo-tracheobronchial Amyloidosis: a Case Report and Review of Literature

Laryngo-tracheobronchial Amyloidosis: a Case Report and Review of Literature

Mixed laryngocoele: A rare cause for acute airway obstruction

Nasopharyngeal and laryngeal amyloidosis: a case report

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