Larvicidal and growth inhibition of the malaria vector Anopheles stephensi by triterpenes from Dysoxylum malabaricum and Dysoxylum beddomei

Senthil-Nathan, Sengottayan; Hisham, A.; Jayakumar, G.

doi:10.1016/j.fitote.2007.07.013

Cited by 72 publications

(23 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results showed that the major malaria vector in India, i.e. A. stephensi, is highly susceptible to potash alum under laboratory conditions and these LC values found in laboratory experiments are similar to those found in earlier studies (Batabyal et al 2007;Nathan et al 2008;Senthilkumar et al 2009). However, there are a number of studies reporting LC 50 values remarkably higher than our study (Sosan et al 2001;Dwivedi and Karwasara 2003).…”

Section: Discussionsupporting

confidence: 87%

Mosquito larvicidal potential of potash alum against malaria vector Anopheles stephensi (Liston)

Preet

Seema

2010

J Parasit Dis

View full text Add to dashboard Cite

Mosquito larviciding may prove to be an effective tool for incorporating into integrated vector management strategies for reducing malaria transmission. Here, we report the potential of potash alum, a traditionally known salt in Indian Ayurveda and Chinese medicine system, in malaria vector control by evaluating its aqueous suspension as larvicide and growth disruptor of Anopheles stephensi, under laboratory conditions. Immature stages of the mosquito were tested using WHO guidelines. 50 and 90% lethal concentrations among various larvae ranged between 2.1 to 48.74 ppm and 15.78 to 93.11 ppm, respectively. The results indicated that larvicidal effects of potash alum were comparable to various biological and chemical insecticides.The study provides considerable scope in exploiting local indigenous resources for the control of nuisance mosquito vectors.

show abstract

Section: Discussionsupporting

confidence: 87%

Mosquito larvicidal potential of potash alum against malaria vector Anopheles stephensi (Liston)

Preet

Seema

2010

J Parasit Dis

View full text Add to dashboard Cite

show abstract

“…aegypti and C. quinquefasciatus, with LC 50 values of 425.94 and 592.60 ppm, respectively (Anees 2008). Nathan et al (2008) reported that the fourth instar larvae of An. stephensi are highly sensitive to the ethyl acetate extract of the leaves of Dysoxylum malabaricum.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of some aromatic plant extracts for mosquito larvicidal potential against Culex quinquefasciatus, Aedes aegypti, and Anopheles stephensi

2015

View full text Add to dashboard Cite

In the present investigation, larvicidal potential of hexane, choloroform, ethyl acetate, acetone, and methanol extracts of seven aromatic plants, viz., Blumea mollis, Chloroxylon swietenia, Clausena anisata, Feronia limnonia, Lantana camera, Plectranthus amboinicus, and Tagetes erecta were screened against Culex quinquefasciatus, Aedes aegypti, and Anopheles stephensi. The larval mortality was observed after 12 and 24 h of exposure period. The results revealed that all the extracts showed varied levels of larvicidal activity against the mosquito species tested. However, the ethyl acetate extract of Chloroxylon swietenia showed the remarkable larvicidal activity against C. quinquefasciatus, Ae. aegypti, and An. stephensi. After 12 h of exposure period, the larvicidal activity was LC50 = 194.22 and LC90 = 458.83 ppm (C. quinquefasciatus), LC50 = 173.04 and LC90 = 442.73 ppm (Ae. aegypti), and LC50 = 167.28 and LC90 = 433.07 ppm (An. stephensi), and the larvicidal activity after 24-h exposure period was LC50 = 94.12 and LC90 = 249.83 ppm (C. quinquefasciatus), LC50 = 80.58 and LC90 = 200.96 ppm (Ae. aegypti), and LC50 = 76.24 and LC90 = 194.51 ppm (An. stephensi). The larvicidal potential of other plant extracts were in order of ethyl acetate extract of Clausena anisata > methanol extract of P. amboinicus > acetone extract of F. limonia > methanol extract of T. erecta > methanol extract of B. mollis > and methanol extract of L. camera. The results of the present study offer a possible way for further investigations to find out the active molecule responsible for the activity.

show abstract

“…Studies carried out by Nyamoita et al, [41], Nathan et al, [45] and Nathan et al, [46] reported that in addition to their lethality, the secondary metabolites of the botanicals used resulted in protracted larval phase, disrupted growth and malformation of the exoskeleton. Although there was no elongation of gut as observed in [29] and [47], incomplete melanization process was observed in larvae and some pupae examined under light microscopy (Fig.…”

Section: Discussionmentioning

confidence: 99%

Methanolic extract of Agerantum conyzoides exhibited toxicity and growth disruption activities against Anopheles gambiae sensu stricto and Anopheles arabiensis larvae

Muema

Njeru

Colombier

et al. 2016

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundVector control remains the mainstay to effective malaria management. The negative implications following persistent application of synthetic insecticides geared towards regulation of mosquito populations have necessitated prospection for ecofriendly effective chemistries. Plant-derived compounds have the potential to control malaria-transmitting mosquito populations. Previously, Agerantum conyzoides extracts have demonstrated toxicity effects on disease-transmitting mosquitoes. However, their efficacy in controlling Afrotropical malaria vectors remains unclear. Herein, the toxicity and growth disruption activities of crude methanolic leaf extract of A. conyzoides on Anopheles gambiae sensu stricto and An. arabiensis larvae were assessed. MethodsLate third (L3) instars of An. gambiae s.s and An. arabiensis larvae were challenged with increasing doses of crude methanolic extract of A. conyzoides. The larval mortality rates were recorded every 24 h and the LC50 values determined at their associated 95% confidence levels. ANOVA followed by Post-hoc Student-Newman-Keuls (SNK) test was used to compare results between treatment and control groups. Phytochemical profiling of the extract was performed using standard chemical procedures.ResultsTreatment of larvae with the methanolic extract depicted dose-dependent effects with highest mortality percentages of ≥ 69% observed when exposed with 250 ppm and 500 ppm for 48 h while growth disruption effects were induced by sublethal doses of between 50–100 ppm for both species. Relative to experimental controls, the extract significantly reduced larval survival in both mosquito species (ANOVA, F(8,126) = 43.16776, P < 0.001). The LC50 values of the extract against An. gambiae s.s ranged between 84.71–232.70 ppm (95% CI 81.17–239.20), while against An. arabiensis the values ranged between 133.46–406.35 ppm (95% CI 131.51–411.25). The development of the juvenile stages was arrested at pupal-larval intermediates and adult emergence. The presence of alkaloids, aglycone flavonoids, triterpenoids, tannins and coumarins can partly be associated with the observed effects.ConclusionThe extract displayed considerable larvicidal activity and inhibited emergence of adult mosquitoes relative to experimental controls, a phenomenon probably associated with induced developmental hormone imbalance. Optimization of the bioactive compounds could open pathways into vector control programmes for improved mosquito control and reduced malaria transmission rates.

show abstract

Larvicidal and growth inhibition of the malaria vector Anopheles stephensi by triterpenes from Dysoxylum malabaricum and Dysoxylum beddomei

Cited by 72 publications

References 21 publications

Mosquito larvicidal potential of potash alum against malaria vector Anopheles stephensi (Liston)

Mosquito larvicidal potential of potash alum against malaria vector Anopheles stephensi (Liston)

Evaluation of some aromatic plant extracts for mosquito larvicidal potential against Culex quinquefasciatus, Aedes aegypti, and Anopheles stephensi

Methanolic extract of Agerantum conyzoides exhibited toxicity and growth disruption activities against Anopheles gambiae sensu stricto and Anopheles arabiensis larvae

Contact Info

Product

Resources

About